Twinfilin - Revision history

Michal Harel at 08:09, 12 June 2022

Michal Harel — Sun, 12 Jun 2022 08:09:42 GMT

←Older revision		Revision as of 08:09, 12 June 2022
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	[[2vac]] – hTwi-2 N-terminal ADF-H domain - human<br />		[[2vac]] – hTwi-2 N-terminal ADF-H domain - human<br />
	[[2w0i]] – hTwi-2 C-terminal ADF-H domain (mutant) <br />		[[2w0i]] – hTwi-2 C-terminal ADF-H domain (mutant) <br />
		+	[[7ccc]] – hTwi-1 + F-actin-capping protein + actin<br />
	[[2hd7]], [[2d8b]] – mTwi-1 C-terminal ADF-H domain – mouse - NMR<br />		[[2hd7]], [[2d8b]] – mTwi-1 C-terminal ADF-H domain – mouse - NMR<br />
	[[1m4j]] – mTwi-1 N-terminal ADF-H domain <br />		[[1m4j]] – mTwi-1 N-terminal ADF-H domain <br />
	[[6rsw]] – mTwi-1 C-terminal ADF-H domain + actin + CAP1<br />		[[6rsw]] – mTwi-1 C-terminal ADF-H domain + actin + CAP1<br />
		+	[[7ds2]] – mTwi-1 C-terminal + F-actin-capping protein<br />
		+	[[7ds4]] – mTwi-1 C-terminal (mutant) + F-actin-capping protein<br />
		+	[[7dsb]] – mTwi-1 C-terminal + F-actin-capping protein + myotrophin<br />
		+	[[7ds3]] – mTwi-2 + F-actin-capping protein<br />
	[[6yp9]] – rTwi-1 C-terminal ADF-H domain + actin - rabbit<br />		[[6yp9]] – rTwi-1 C-terminal ADF-H domain + actin - rabbit<br />
	[[3daw]] – rTwi-1 C-terminal ADF-H domain (mutant) + actin + ATP<br />		[[3daw]] – rTwi-1 C-terminal ADF-H domain (mutant) + actin + ATP<br />

Michal Harel at 10:51, 24 December 2020

Michal Harel — Thu, 24 Dec 2020 10:51:26 GMT

←Older revision		Revision as of 10:51, 24 December 2020
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	[[1m4j]] – mTwi-1 N-terminal ADF-H domain <br />		[[1m4j]] – mTwi-1 N-terminal ADF-H domain <br />
	[[6rsw]] – mTwi-1 C-terminal ADF-H domain + actin + CAP1<br />		[[6rsw]] – mTwi-1 C-terminal ADF-H domain + actin + CAP1<br />
-	[[3daw]] – ~~Twi~~-1 C-terminal ADF-H domain (mutant) + actin + ATP ~~- rabbit~~<br />	+	[[6yp9]] – rTwi-1 C-terminal ADF-H domain + actin - rabbit<br />
		+	[[3daw]] – rTwi-1 C-terminal ADF-H domain (mutant) + actin + ATP<br />
		+	[[6k2f]] – Twi – ''Entamoeba histolytica''<br />

	== References ==		== References ==

Michal Harel at 07:41, 16 March 2020

Michal Harel — Mon, 16 Mar 2020 07:41:44 GMT

←Older revision		Revision as of 07:41, 16 March 2020
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		+	[[2vac]] – hTwi-2 N-terminal ADF-H domain - human<br />
		+	[[2w0i]] – hTwi-2 C-terminal ADF-H domain (mutant) <br />
	[[2hd7]], [[2d8b]] – mTwi-1 C-terminal ADF-H domain – mouse - NMR<br />		[[2hd7]], [[2d8b]] – mTwi-1 C-terminal ADF-H domain – mouse - NMR<br />
	[[1m4j]] – mTwi-1 N-terminal ADF-H domain <br />		[[1m4j]] – mTwi-1 N-terminal ADF-H domain <br />
		+	[[6rsw]] – mTwi-1 C-terminal ADF-H domain + actin + CAP1<br />
	[[3daw]] – Twi-1 C-terminal ADF-H domain (mutant) + actin + ATP - rabbit<br />		[[3daw]] – Twi-1 C-terminal ADF-H domain (mutant) + actin + ATP - rabbit<br />
-	[[2vac]] – hTwi-2 N-terminal ADF-H domain - human<br />
-	[[2w0i]] – hTwi-2 C-terminal ADF-H domain (mutant) <br />
-

	== References ==		== References ==

Alexander Berchansky at 13:46, 6 October 2019

Alexander Berchansky — Sun, 06 Oct 2019 13:46:09 GMT

←Older revision		Revision as of 13:46, 6 October 2019
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	== Structural highlights ==		== Structural highlights ==

-	The twinfilin-1 C-terminal ADF-H domain binds to a groove between two subdomains of actin. <scene name='80/805029/Cv/4'>Three major sites of interaction can be distinguished</scene>. These interactions include <scene name='80/805029/Cv/3'>hydrogen bonds</scene> (twinfilin residues participating in interactions are colored in magenta) and <scene name='80/805029/Cv/5'>hydrophobic contacts</scene> (actin residues participating in interactions are colored according to hydrophobic/polar)<ref>PMID:18625842</ref>.	+	The twinfilin-1 C-terminal ADF-H domain binds to a groove between two subdomains of actin. <scene name='80/805029/Cv/6'>Three major sites of interaction can be distinguished</scene>. These interactions include <scene name='80/805029/Cv/7'>hydrogen bonds</scene> (twinfilin residues participating in interactions are colored in magenta) and <scene name='80/805029/Cv/8'>hydrophobic contacts</scene> (actin residues participating in interactions are colored according to hydrophobic/polar)<ref>PMID:18625842</ref>.

	</StructureSection>		</StructureSection>

Alexander Berchansky at 11:54, 2 January 2019

Alexander Berchansky — Wed, 02 Jan 2019 11:54:43 GMT

←Older revision		Revision as of 11:54, 2 January 2019
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	== Structural highlights ==		== Structural highlights ==

-	The twinfilin-1 C-terminal ADF-H domain binds to a groove between two subdomains of actin. <scene name='80/805029/Cv/4'>Three major sites of interaction can be distinguished</scene>. These interactions include <scene name='80/805029/Cv/3'>hydrogen bonds</scene> (twinfilin residues are colored in magenta) and <scene name='80/805029/Cv/5'>hydrophobic contacts</scene> (actin residues are colored according to hydrophobic/polar)<ref>PMID:18625842</ref>.	+	The twinfilin-1 C-terminal ADF-H domain binds to a groove between two subdomains of actin. <scene name='80/805029/Cv/4'>Three major sites of interaction can be distinguished</scene>. These interactions include <scene name='80/805029/Cv/3'>hydrogen bonds</scene> (twinfilin residues participating in interactions are colored in magenta) and <scene name='80/805029/Cv/5'>hydrophobic contacts</scene> (actin residues participating in interactions are colored according to hydrophobic/polar)<ref>PMID:18625842</ref>.

	</StructureSection>		</StructureSection>

Alexander Berchansky at 11:53, 2 January 2019

Alexander Berchansky — Wed, 02 Jan 2019 11:53:40 GMT

←Older revision		Revision as of 11:53, 2 January 2019
Line 11:		Line 11:
	== Structural highlights ==		== Structural highlights ==

-	The twinfilin-1 C-terminal ADF-H domain binds to a groove between two subdomains of actin. <scene name='80/805029/Cv/4'>Three major sites of interaction can be distinguished</scene>. These interactions include <scene name='80/805029/Cv/3'>hydrogen bonds</scene> and hydrophobic contacts<ref>PMID:18625842</ref>.	+	The twinfilin-1 C-terminal ADF-H domain binds to a groove between two subdomains of actin. <scene name='80/805029/Cv/4'>Three major sites of interaction can be distinguished</scene>. These interactions include <scene name='80/805029/Cv/3'>hydrogen bonds</scene> (twinfilin residues are colored in magenta) and <scene name='80/805029/Cv/5'>hydrophobic contacts</scene> (actin residues are colored according to hydrophobic/polar)<ref>PMID:18625842</ref>.

	</StructureSection>		</StructureSection>

Alexander Berchansky at 11:46, 2 January 2019

Alexander Berchansky — Wed, 02 Jan 2019 11:46:54 GMT

←Older revision		Revision as of 11:46, 2 January 2019
Line 11:		Line 11:
	== Structural highlights ==		== Structural highlights ==

-	The twinfilin-1 C-terminal ADF-H domain binds to a groove between two subdomains of actin. <scene name='80/805029/Cv/2'>Three major sites of interaction can be distinguished</scene>. These interactions include <scene name='80/805029/Cv/3'>hydrogen bonds</scene> and hydrophobic contacts<ref>PMID:18625842</ref>.	+	The twinfilin-1 C-terminal ADF-H domain binds to a groove between two subdomains of actin. <scene name='80/805029/Cv/4'>Three major sites of interaction can be distinguished</scene>. These interactions include <scene name='80/805029/Cv/3'>hydrogen bonds</scene> and hydrophobic contacts<ref>PMID:18625842</ref>.

	</StructureSection>		</StructureSection>

Alexander Berchansky at 11:44, 2 January 2019

Alexander Berchansky — Wed, 02 Jan 2019 11:44:54 GMT

←Older revision		Revision as of 11:44, 2 January 2019
Line 11:		Line 11:
	== Structural highlights ==		== Structural highlights ==

-	The twinfilin-1 C-terminal ADF-H domain binds to a groove between two subdomains of actin. <scene name='80/805029/Cv/2'>Three major sites of interaction can be distinguished</scene>. These interactions include hydrogen bonds and hydrophobic contacts<ref>PMID:18625842</ref>.	+	The twinfilin-1 C-terminal ADF-H domain binds to a groove between two subdomains of actin. <scene name='80/805029/Cv/2'>Three major sites of interaction can be distinguished</scene>. These interactions include <scene name='80/805029/Cv/3'>hydrogen bonds</scene> and hydrophobic contacts<ref>PMID:18625842</ref>.

	</StructureSection>		</StructureSection>

Alexander Berchansky at 11:12, 2 January 2019

Alexander Berchansky — Wed, 02 Jan 2019 11:12:24 GMT

←Older revision		Revision as of 11:12, 2 January 2019
Line 11:		Line 11:
	== Structural highlights ==		== Structural highlights ==

-	The twinfilin-1 C-terminal ADF-H domain binds to a groove between two subdomains of actin. Three major sites of interaction can be distinguished. These interactions include hydrogen bonds and hydrophobic contacts<ref>PMID:18625842</ref>.	+	The twinfilin-1 C-terminal ADF-H domain binds to a groove between two subdomains of actin. <scene name='80/805029/Cv/2'>Three major sites of interaction can be distinguished</scene>. These interactions include hydrogen bonds and hydrophobic contacts<ref>PMID:18625842</ref>.

	</StructureSection>		</StructureSection>

Alexander Berchansky at 11:04, 2 January 2019

Alexander Berchansky — Wed, 02 Jan 2019 11:04:38 GMT

←Older revision		Revision as of 11:04, 2 January 2019
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-	<StructureSection load='3daw' size='~~340~~' side='right' caption='Structure of twinfilin-1 C-terminal ADF-H domain (green) complex with actin (~~grey~~), ATP and Ca+2 ion (green (PDB code [[3daw]])' scene=''>	+	<StructureSection load='3daw' size='400' side='right' caption='Structure of twinfilin-1 C-terminal ADF-H domain (green) complex with actin (cyan), ATP and Ca+2 ion (green (PDB code [[3daw]])' scene='80/805029/Cv/1'>

	== Function ==		== Function ==