Undecaprenyl pyrophosphate synthase - Revision history

Michal Harel at 11:40, 11 March 2024

Michal Harel — Mon, 11 Mar 2024 11:40:33 GMT

←Older revision		Revision as of 11:40, 11 March 2024
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	== Structural highlights ==		== Structural highlights ==
	The <scene name='59/591995/Cv/5'>active site</scene> of UPPS (water molecules are shown as red spheres) contains an <scene name='59/591995/Cv/6'>octahedrally coordinated Mg+2 ion bound to the pyrophosphate group of isopentenyl pyrophosphate</scene><ref>PMID:15788389</ref>.		The <scene name='59/591995/Cv/5'>active site</scene> of UPPS (water molecules are shown as red spheres) contains an <scene name='59/591995/Cv/6'>octahedrally coordinated Mg+2 ion bound to the pyrophosphate group of isopentenyl pyrophosphate</scene><ref>PMID:15788389</ref>.
-	</StructureSection>

	==3D structures of undecaprenyl pyrophosphate synthase==		==3D structures of undecaprenyl pyrophosphate synthase==

-	~~Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}~~	+	[[Undecaprenyl pyrophosphate synthase 3D structures]]
-	~~{{#tree:id=OrganizedByTopic\|openlevels=0\|~~	+
-		+
-	*Undecaprenyl pyrophosphate synthase	+
-		+
-	**[[~~1f75]] – UPPS (mutant) – ''Micrococcus luteus''<br />~~	+
-	**[[3qas]], [[5cqb]], [[5oon]], [[6cb2]] – EcUPPS – ''Escherichia coli''<br />	+
-	**[[1jp3]] – EcUPPS (mutant) <br />	+
-	**[[2d2r]] – HpUPPS (mutant) – ''Helicobacter pylori''<br />	+
-	**[[2vg4]] – MtUPPS – ''Mycobacterium tuberculosis''<br />	+
-	**[[5kh2]] – SpUPPS – ''Streptococcus pneumoniae''<br />	+
-	**[[3wyi]] – SaUPPS - ''Staphylococcus aureus'' <br />	+
-	**[[5xk3]] – StUPPS – ''Streptmyces''<br />	+
-	**[[6acs]] - AbUPPS - ''Acinetobacter baumannii''<br />	+
-	**[[6loi]] - AbUPPS - ''Enterococcus faecalis''<br />	+
-	**[[7jli]] – BsUPPS – ''Bacillus subtilis''<br />	+
-		+
-	*Undecaprenyl pyrophosphate synthase ~~complexes~~	+
-		+
-	**[[1ueh]] – EcUPPS + Mg + SO4 + triton<br />	+
-	**[[1v7u]] – EcUPPS + FPP <br />	+
-	**[[4u82]] – EcUPPS + Mg + FPP derivative<br />	+
-	**[[1x06]] – EcUPPS + Mg + FPP analog + IPP<br />	+
-	**[[1x08]] – EcUPPS (mutant) + Mg + FPP analog + IPP<br />	+
-	**[[1x07]] – EcUPPS + Mg + PO4 + IPP<br />	+
-	**[[1x09]] – EcUPPS (mutant) + Mg + IPP<br />	+
-	**[[2e98]], [[2e99]], [[2e9a]], [[2e9c]], [[2e9d]], [[3th8]], [[3sgt]], [[3sgv]], [[3sgx]], [[3sh0]], [[4h2j]], [[4h2m]], [[4h2o]], [[4h38]], [[4h3c]], [[4h3a]], [[4h8e]], [[3wyj]] – EcUPP + bisphosphonate<br />	+
-	**[[5cqj]], [[5zhe]] – EcUPPS + inhibitor <br />	+
-	**[[5kh4]] – SpUPPS + FPP <br />	+
-	**[[5kh5]] – SpUPPS + inhibitor <br />	+
-	**[[2dtn]] – HpUPPS + pyrophosphate<br />	+
-	**[[3ugs]] - UPPS + FPP analog – ''Campylobacter jejuni''<br />	+
-	**[[2vg2]] – MtUPPS + Pi + PPi + methyl butenyl diphosphate <br />	+
-	**[[2vg3]] – MtUPPS + Pi + Mg + geranyl diphosphate <br />	+
-	**[[5xk8]] – StUPPS + GPP <br />	+
-	**[[5xk6]] – StUPPS + IPP <br />	+
-	**[[5xk7]] – StUPPS + DMAPP <br />	+
-	**[[5xk9]] – StUPPS + GSPP + DMAPP <br />	+
-	**[[6szg]], [[6szh]] - AbUPPS + inhibitor<br />	+
-	**[[7jlj]], [[7jlm]], [[7jlr]] – BsUPPS + inhibitor <br />	+
-		+
-	*Nuclear UPPS or NUS1 or dehydrodolichyl diphosphate synthase complex subunit NUS1	+
-		+
-	**[[6z1n]], [[7pay]] – hNUS1 + hDHDDS<br />	+
-	**[[6w2l]] – hNUS1 + hDHDDS + IPP<br />	+
-	**[[7pax]] – hNUS1 + hDHDDS + FSPP + IPP<br />	+
-	**[[7pb0]] – hNUS1 + hDHDDS + GGSPP + ISPP<br />	+
-	**[[6jcn]] ~~– yNUS1 - yeast<br />~~	+
-	}}	+

	== References ==		== References ==
	<references/>		<references/>
-		+	</StructureSection>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 11:37, 11 March 2024

Michal Harel — Mon, 11 Mar 2024 11:37:34 GMT

←Older revision		Revision as of 11:37, 11 March 2024
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	== Structural highlights ==		== Structural highlights ==
-	The <scene name='59/591995/Cv/5'>active site</scene> of ~~UPP~~ (water molecules are shown as red spheres) contains an <scene name='59/591995/Cv/6'>octahedrally coordinated Mg+2 ion bound to the pyrophosphate group of isopentenyl pyrophosphate</scene><ref>PMID:15788389</ref>.	+	The <scene name='59/591995/Cv/5'>active site</scene> of UPPS (water molecules are shown as red spheres) contains an <scene name='59/591995/Cv/6'>octahedrally coordinated Mg+2 ion bound to the pyrophosphate group of isopentenyl pyrophosphate</scene><ref>PMID:15788389</ref>.
	</StructureSection>		</StructureSection>

Line 18:		Line 18:
	*Undecaprenyl pyrophosphate synthase		*Undecaprenyl pyrophosphate synthase

-	**[[1f75]] – ~~UPP~~ (mutant) – ''Micrococcus luteus''<br />	+	**[[1f75]] – UPPS (mutant) – ''Micrococcus luteus''<br />
-	**[[3qas]], [[5cqb]], [[5oon]], [[6cb2]] – ~~EcUPP~~ – ''Escherichia coli''<br />	+	**[[3qas]], [[5cqb]], [[5oon]], [[6cb2]] – EcUPPS – ''Escherichia coli''<br />
-	**[[1jp3]] – ~~EcUPP~~ (mutant) <br />	+	**[[1jp3]] – EcUPPS (mutant) <br />
-	**[[2d2r]] – ~~HpUPP~~ (mutant) – ''Helicobacter pylori''<br />	+	**[[2d2r]] – HpUPPS (mutant) – ''Helicobacter pylori''<br />
-	**[[2vg4]] – ~~MtUPP~~ – ''Mycobacterium tuberculosis''<br />	+	**[[2vg4]] – MtUPPS – ''Mycobacterium tuberculosis''<br />
-	**[[5kh2]] – ~~SpUPP~~ – ''Streptococcus pneumoniae''<br />	+	**[[5kh2]] – SpUPPS – ''Streptococcus pneumoniae''<br />
-	**[[3wyi]] – ~~SaUPP~~ - ''Staphylococcus aureus'' <br />	+	**[[3wyi]] – SaUPPS - ''Staphylococcus aureus'' <br />
-	**[[5xk3]] – ~~StUPP~~ – ''Streptmyces''<br />	+	**[[5xk3]] – StUPPS – ''Streptmyces''<br />
-	**[[6acs]] - ~~AbUPP~~ - ''Acinetobacter baumannii''<br />	+	**[[6acs]] - AbUPPS - ''Acinetobacter baumannii''<br />
-	**[[6loi]] - ~~AbUPP~~ - ''Enterococcus faecalis''<br />	+	**[[6loi]] - AbUPPS - ''Enterococcus faecalis''<br />
-	**[[7jli]] – ~~BsUPP~~ – ''Bacillus subtilis''<br />	+	**[[7jli]] – BsUPPS – ''Bacillus subtilis''<br />

	*Undecaprenyl pyrophosphate synthase complexes		*Undecaprenyl pyrophosphate synthase complexes

-	**[[1ueh]] – ~~EcUPP~~ + Mg + SO4 + triton<br />	+	**[[1ueh]] – EcUPPS + Mg + SO4 + triton<br />
-	**[[1v7u]] – ~~EcUPP~~ + FPP <br />	+	**[[1v7u]] – EcUPPS + FPP <br />
-	**[[4u82]] – ~~EcUPP~~ + Mg + FPP derivative<br />	+	**[[4u82]] – EcUPPS + Mg + FPP derivative<br />
-	**[[1x06]] – ~~EcUPP~~ + Mg + FPP analog + IPP<br />	+	**[[1x06]] – EcUPPS + Mg + FPP analog + IPP<br />
-	**[[1x08]] – ~~EcUPP~~ (mutant) + Mg + FPP analog + IPP<br />	+	**[[1x08]] – EcUPPS (mutant) + Mg + FPP analog + IPP<br />
-	**[[1x07]] – ~~EcUPP~~ + Mg + PO4 + IPP<br />	+	**[[1x07]] – EcUPPS + Mg + PO4 + IPP<br />
-	**[[1x09]] – ~~EcUPP~~ (mutant) + Mg + IPP<br />	+	**[[1x09]] – EcUPPS (mutant) + Mg + IPP<br />
	**[[2e98]], [[2e99]], [[2e9a]], [[2e9c]], [[2e9d]], [[3th8]], [[3sgt]], [[3sgv]], [[3sgx]], [[3sh0]], [[4h2j]], [[4h2m]], [[4h2o]], [[4h38]], [[4h3c]], [[4h3a]], [[4h8e]], [[3wyj]] – EcUPP + bisphosphonate<br />		**[[2e98]], [[2e99]], [[2e9a]], [[2e9c]], [[2e9d]], [[3th8]], [[3sgt]], [[3sgv]], [[3sgx]], [[3sh0]], [[4h2j]], [[4h2m]], [[4h2o]], [[4h38]], [[4h3c]], [[4h3a]], [[4h8e]], [[3wyj]] – EcUPP + bisphosphonate<br />
-	**[[5cqj]], [[5zhe]] – ~~EcUPP~~ + inhibitor <br />	+	**[[5cqj]], [[5zhe]] – EcUPPS + inhibitor <br />
-	**[[5kh4]] – ~~SpUPP~~ + FPP <br />	+	**[[5kh4]] – SpUPPS + FPP <br />
-	**[[5kh5]] – ~~SpUPP~~ + inhibitor <br />	+	**[[5kh5]] – SpUPPS + inhibitor <br />
-	**[[2dtn]] – ~~HpUPP~~ + pyrophosphate<br />	+	**[[2dtn]] – HpUPPS + pyrophosphate<br />
-	**[[3ugs]] - ~~UPP~~ + FPP analog – ''Campylobacter jejuni''<br />	+	**[[3ugs]] - UPPS + FPP analog – ''Campylobacter jejuni''<br />
-	**[[2vg2]] – ~~MtUPP~~ + Pi + PPi + methyl butenyl diphosphate <br />	+	**[[2vg2]] – MtUPPS + Pi + PPi + methyl butenyl diphosphate <br />
-	**[[2vg3]] – ~~MtUPP~~ + Pi + Mg + geranyl diphosphate <br />	+	**[[2vg3]] – MtUPPS + Pi + Mg + geranyl diphosphate <br />
-	**[[5xk8]] – ~~StUPP~~ + GPP <br />	+	**[[5xk8]] – StUPPS + GPP <br />
-	**[[5xk6]] – ~~StUPP~~ + IPP <br />	+	**[[5xk6]] – StUPPS + IPP <br />
-	**[[5xk7]] – ~~StUPP~~ + DMAPP <br />	+	**[[5xk7]] – StUPPS + DMAPP <br />
-	**[[5xk9]] – ~~StUPP~~ + GSPP + DMAPP <br />	+	**[[5xk9]] – StUPPS + GSPP + DMAPP <br />
-	**[[6szg]], [[6szh]] - ~~AbUPP~~ + inhibitor<br />	+	**[[6szg]], [[6szh]] - AbUPPS + inhibitor<br />
-	**[[~~7jljj~~]], [[7jlm]], [[7jlr]] – ~~BsUPP~~ + inhibitor <br />	+	**[[7jlj]], [[7jlm]], [[7jlr]] – BsUPPS + inhibitor <br />
		+
		+	*Nuclear UPPS or NUS1 or dehydrodolichyl diphosphate synthase complex subunit NUS1
		+
		+	**[[6z1n]], [[7pay]] – hNUS1 + hDHDDS<br />
		+	**[[6w2l]] – hNUS1 + hDHDDS + IPP<br />
		+	**[[7pax]] – hNUS1 + hDHDDS + FSPP + IPP<br />
		+	**[[7pb0]] – hNUS1 + hDHDDS + GGSPP + ISPP<br />
		+	**[[6jcn]] – yNUS1 - yeast<br />
	}}		}}

Michal Harel at 11:14, 11 March 2024

Michal Harel — Mon, 11 Mar 2024 11:14:54 GMT

←Older revision		Revision as of 11:14, 11 March 2024
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	== Function ==		== Function ==
-	'''Undecaprenyl pyrophosphate synthase''' or '''isoprenyl transferase''' or '''poly-cis-prenyltransferase''' or '''ditrans,polycis-undecaprenyl pyrophosphate synthase ((2E,6E) farnesyl diphosphate specific)''' (~~UPP~~) catalyzes the consecutive condensation of farnesyl pyrophosphate (FPP) with 8 molecules of isopentenyl pyrophosphate (IPP) to produce undecaprenyl pyrophosphate. Undecaprenyl pyrophosphate serves as a lipid carrier for peptidoglycan synthesis of bacterial cell wall<ref>PMID:15788389</ref>. Bisphosphonate drugs are UPP inhibitors.	+	'''Undecaprenyl pyrophosphate synthase''' or '''isoprenyl transferase''' or '''poly-cis-prenyltransferase''' or '''ditrans,polycis-undecaprenyl pyrophosphate synthase ((2E,6E) farnesyl diphosphate specific)''' (UPPS) catalyzes the consecutive condensation of farnesyl pyrophosphate (FPP) with 8 molecules of isopentenyl pyrophosphate (IPP) to produce undecaprenyl pyrophosphate. Undecaprenyl pyrophosphate serves as a lipid carrier for peptidoglycan synthesis of bacterial cell wall<ref>PMID:15788389</ref>. UPPS or '''NUS1''' is a subunit of ''cis''-prenyltransferase<ref>PMID:27402831</ref>. Bisphosphonate drugs are UPP inhibitors.

	== Relevance ==		== Relevance ==
-	~~UPP~~ inhibitors are investigated as potential antibacterials<ref>PMID:26718796</ref>.	+	UPPS inhibitors are investigated as potential antibacterials<ref>PMID:26718796</ref>.

	== Structural highlights ==		== Structural highlights ==

Michal Harel at 08:49, 20 June 2022

Michal Harel — Mon, 20 Jun 2022 08:49:15 GMT

←Older revision		Revision as of 08:49, 20 June 2022
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	**[[6acs]] - AbUPP - ''Acinetobacter baumannii''<br />		**[[6acs]] - AbUPP - ''Acinetobacter baumannii''<br />
	**[[6loi]] - AbUPP - ''Enterococcus faecalis''<br />		**[[6loi]] - AbUPP - ''Enterococcus faecalis''<br />
		+	**[[7jli]] – BsUPP – ''Bacillus subtilis''<br />

	*Undecaprenyl pyrophosphate synthase complexes		*Undecaprenyl pyrophosphate synthase complexes
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	**[[5xk9]] – StUPP + GSPP + DMAPP <br />		**[[5xk9]] – StUPP + GSPP + DMAPP <br />
	**[[6szg]], [[6szh]] - AbUPP + inhibitor<br />		**[[6szg]], [[6szh]] - AbUPP + inhibitor<br />
		+	**[[7jljj]], [[7jlm]], [[7jlr]] – BsUPP + inhibitor <br />
	}}		}}

Alexander Berchansky at 11:51, 12 January 2022

Alexander Berchansky — Wed, 12 Jan 2022 11:51:30 GMT

←Older revision		Revision as of 11:51, 12 January 2022
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	== Function ==		== Function ==
-	'''Undecaprenyl pyrophosphate synthase''' or '''isoprenyl ~~transfe rase~~''' or '''poly-cis-prenyltransferase''' or '''ditrans,polycis-undecaprenyl pyrophosphate synthase ((2E,6E) farnesyl diphosphate specific)''' (UPP) catalyzes the consecutive condensation of farnesyl pyrophosphate (FPP) with 8 molecules of isopentenyl pyrophosphate (IPP) to produce undecaprenyl pyrophosphate. Undecaprenyl pyrophosphate serves as a lipid carrier for peptidoglycan synthesis of bacterial cell wall<ref>PMID:15788389</ref>. Bisphosphonate drugs are UPP inhibitors.	+	'''Undecaprenyl pyrophosphate synthase''' or '''isoprenyl transferase''' or '''poly-cis-prenyltransferase''' or '''ditrans,polycis-undecaprenyl pyrophosphate synthase ((2E,6E) farnesyl diphosphate specific)''' (UPP) catalyzes the consecutive condensation of farnesyl pyrophosphate (FPP) with 8 molecules of isopentenyl pyrophosphate (IPP) to produce undecaprenyl pyrophosphate. Undecaprenyl pyrophosphate serves as a lipid carrier for peptidoglycan synthesis of bacterial cell wall<ref>PMID:15788389</ref>. Bisphosphonate drugs are UPP inhibitors.

	== Relevance ==		== Relevance ==

Michal Harel at 08:07, 7 January 2021

Michal Harel — Thu, 07 Jan 2021 08:07:14 GMT

←Older revision		Revision as of 08:07, 7 January 2021
Line 2:		Line 2:

	== Function ==		== Function ==
-	'''Undecaprenyl pyrophosphate synthase''' or '''isoprenyl ~~transferase~~''' or '''poly-~~cys~~-prenyltransferase''' (UPP) catalyzes the consecutive condensation of farnesyl pyrophosphate (FPP) with 8 molecules of isopentenyl pyrophosphate (IPP) to produce undecaprenyl pyrophosphate. Undecaprenyl pyrophosphate serves as a lipid carrier for peptidoglycan synthesis of bacterial cell wall<ref>PMID:15788389</ref>. Bisphosphonate drugs are UPP inhibitors.	+	'''Undecaprenyl pyrophosphate synthase''' or '''isoprenyl transfe rase''' or '''poly-cis-prenyltransferase''' or '''ditrans,polycis-undecaprenyl pyrophosphate synthase ((2E,6E) farnesyl diphosphate specific)''' (UPP) catalyzes the consecutive condensation of farnesyl pyrophosphate (FPP) with 8 molecules of isopentenyl pyrophosphate (IPP) to produce undecaprenyl pyrophosphate. Undecaprenyl pyrophosphate serves as a lipid carrier for peptidoglycan synthesis of bacterial cell wall<ref>PMID:15788389</ref>. Bisphosphonate drugs are UPP inhibitors.

	== Relevance ==		== Relevance ==
Line 27:		Line 27:
	**[[5xk3]] – StUPP – ''Streptmyces''<br />		**[[5xk3]] – StUPP – ''Streptmyces''<br />
	**[[6acs]] - AbUPP - ''Acinetobacter baumannii''<br />		**[[6acs]] - AbUPP - ''Acinetobacter baumannii''<br />
		+	**[[6loi]] - AbUPP - ''Enterococcus faecalis''<br />

	*Undecaprenyl pyrophosphate synthase complexes		*Undecaprenyl pyrophosphate synthase complexes

Michal Harel at 06:58, 7 January 2021

Michal Harel — Thu, 07 Jan 2021 06:58:16 GMT

←Older revision		Revision as of 06:58, 7 January 2021
Line 2:		Line 2:

	== Function ==		== Function ==
-	'''Undecaprenyl pyrophosphate synthase''' (UPP) catalyzes the consecutive condensation of farnesyl pyrophosphate (FPP) with 8 molecules of isopentenyl pyrophosphate (IPP) to produce undecaprenyl pyrophosphate. Undecaprenyl pyrophosphate serves as a lipid carrier for peptidoglycan synthesis of bacterial cell wall<ref>PMID:15788389</ref>. Bisphosphonate drugs are UPP inhibitors.	+	'''Undecaprenyl pyrophosphate synthase''' or '''isoprenyl transferase''' or '''poly-cys-prenyltransferase''' (UPP) catalyzes the consecutive condensation of farnesyl pyrophosphate (FPP) with 8 molecules of isopentenyl pyrophosphate (IPP) to produce undecaprenyl pyrophosphate. Undecaprenyl pyrophosphate serves as a lipid carrier for peptidoglycan synthesis of bacterial cell wall<ref>PMID:15788389</ref>. Bisphosphonate drugs are UPP inhibitors.

	== Relevance ==		== Relevance ==
Line 26:		Line 26:
	**[[3wyi]] – SaUPP - ''Staphylococcus aureus'' <br />		**[[3wyi]] – SaUPP - ''Staphylococcus aureus'' <br />
	**[[5xk3]] – StUPP – ''Streptmyces''<br />		**[[5xk3]] – StUPP – ''Streptmyces''<br />
		+	**[[6acs]] - AbUPP - ''Acinetobacter baumannii''<br />

	*Undecaprenyl pyrophosphate synthase complexes		*Undecaprenyl pyrophosphate synthase complexes
Line 37:		Line 38:
	**[[1x09]] – EcUPP (mutant) + Mg + IPP<br />		**[[1x09]] – EcUPP (mutant) + Mg + IPP<br />
	**[[2e98]], [[2e99]], [[2e9a]], [[2e9c]], [[2e9d]], [[3th8]], [[3sgt]], [[3sgv]], [[3sgx]], [[3sh0]], [[4h2j]], [[4h2m]], [[4h2o]], [[4h38]], [[4h3c]], [[4h3a]], [[4h8e]], [[3wyj]] – EcUPP + bisphosphonate<br />		**[[2e98]], [[2e99]], [[2e9a]], [[2e9c]], [[2e9d]], [[3th8]], [[3sgt]], [[3sgv]], [[3sgx]], [[3sh0]], [[4h2j]], [[4h2m]], [[4h2o]], [[4h38]], [[4h3c]], [[4h3a]], [[4h8e]], [[3wyj]] – EcUPP + bisphosphonate<br />
-	**[[5cqj]] – EcUPP + inhibitor <br />	+	**[[5cqj]], [[5zhe]] – EcUPP + inhibitor <br />
	**[[5kh4]] – SpUPP + FPP <br />		**[[5kh4]] – SpUPP + FPP <br />
	**[[5kh5]] – SpUPP + inhibitor <br />		**[[5kh5]] – SpUPP + inhibitor <br />
Line 48:		Line 49:
	**[[5xk7]] – StUPP + DMAPP <br />		**[[5xk7]] – StUPP + DMAPP <br />
	**[[5xk9]] – StUPP + GSPP + DMAPP <br />		**[[5xk9]] – StUPP + GSPP + DMAPP <br />
-	**[[6szg]], [[6szh]] - ~~UPP~~ + ~~inhibitors - ''Acinetobacter baumannii''~~<br />	+	**[[6szg]], [[6szh]] - AbUPP + inhibitor<br />
	}}		}}

Michal Harel at 11:41, 19 March 2020

Michal Harel — Thu, 19 Mar 2020 11:41:51 GMT

←Older revision		Revision as of 11:41, 19 March 2020
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	**[[5xk7]] – StUPP + DMAPP <br />		**[[5xk7]] – StUPP + DMAPP <br />
	**[[5xk9]] – StUPP + GSPP + DMAPP <br />		**[[5xk9]] – StUPP + GSPP + DMAPP <br />
		+	**[[6szg]], [[6szh]] - UPP + inhibitors - ''Acinetobacter baumannii''<br />
	}}		}}

Alexander Berchansky at 12:06, 10 October 2019

Alexander Berchansky — Thu, 10 Oct 2019 12:06:43 GMT

←Older revision		Revision as of 12:06, 10 October 2019
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	== Structural highlights ==		== Structural highlights ==
-	The <scene name='59/591995/Cv/3'>active site</scene> of UPP contains an <scene name='59/591995/Cv/1'>octahedrally coordinated Mg+2 ion bound to the pyrophosphate group of isopentenyl pyrophosphate</scene><ref>PMID:15788389</ref>~~. Water molecules shown as red spheres~~.	+	The <scene name='59/591995/Cv/5'>active site</scene> of UPP (water molecules are shown as red spheres) contains an <scene name='59/591995/Cv/6'>octahedrally coordinated Mg+2 ion bound to the pyrophosphate group of isopentenyl pyrophosphate</scene><ref>PMID:15788389</ref>.
	</StructureSection>		</StructureSection>

Michal Harel at 21:28, 4 October 2018

Michal Harel — Thu, 04 Oct 2018 21:28:37 GMT

←Older revision		Revision as of 21:28, 4 October 2018
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-	<StructureSection load='1x07' size='~~450~~' side='right' caption='Structure of E. coli UPP complex with isopentenyl pyrophosphate, phosphate and Mg+2 (green) (PDB code [[1x07]]).' scene='59/591995/Cv/4' pspeed='8'>	+	<StructureSection load='1x07' size='350' side='right' caption='Structure of E. coli UPP complex with isopentenyl pyrophosphate, phosphate and Mg+2 (green) (PDB code [[1x07]]).' scene='59/591995/Cv/4' pspeed='8'>

	== Function ==		== Function ==
Line 19:		Line 19:

	**[[1f75]] – UPP (mutant) – ''Micrococcus luteus''<br />		**[[1f75]] – UPP (mutant) – ''Micrococcus luteus''<br />
-	**[[3qas]], [[5cqb]] – EcUPP – ''Escherichia coli''<br />	+	**[[3qas]], [[5cqb]], [[5oon]], [[6cb2]] – EcUPP – ''Escherichia coli''<br />
	**[[1jp3]] – EcUPP (mutant) <br />		**[[1jp3]] – EcUPP (mutant) <br />
	**[[2d2r]] – HpUPP (mutant) – ''Helicobacter pylori''<br />		**[[2d2r]] – HpUPP (mutant) – ''Helicobacter pylori''<br />
	**[[2vg4]] – MtUPP – ''Mycobacterium tuberculosis''<br />		**[[2vg4]] – MtUPP – ''Mycobacterium tuberculosis''<br />
	**[[5kh2]] – SpUPP – ''Streptococcus pneumoniae''<br />		**[[5kh2]] – SpUPP – ''Streptococcus pneumoniae''<br />
		+	**[[3wyi]] – SaUPP - ''Staphylococcus aureus'' <br />
		+	**[[5xk3]] – StUPP – ''Streptmyces''<br />

	*Undecaprenyl pyrophosphate synthase complexes		*Undecaprenyl pyrophosphate synthase complexes
Line 29:		Line 31:
	**[[1ueh]] – EcUPP + Mg + SO4 + triton<br />		**[[1ueh]] – EcUPP + Mg + SO4 + triton<br />
	**[[1v7u]] – EcUPP + FPP <br />		**[[1v7u]] – EcUPP + FPP <br />
		+	**[[4u82]] – EcUPP + Mg + FPP derivative<br />
	**[[1x06]] – EcUPP + Mg + FPP analog + IPP<br />		**[[1x06]] – EcUPP + Mg + FPP analog + IPP<br />
	**[[1x08]] – EcUPP (mutant) + Mg + FPP analog + IPP<br />		**[[1x08]] – EcUPP (mutant) + Mg + FPP analog + IPP<br />
Line 41:		Line 44:
	**[[2vg2]] – MtUPP + Pi + PPi + methyl butenyl diphosphate <br />		**[[2vg2]] – MtUPP + Pi + PPi + methyl butenyl diphosphate <br />
	**[[2vg3]] – MtUPP + Pi + Mg + geranyl diphosphate <br />		**[[2vg3]] – MtUPP + Pi + Mg + geranyl diphosphate <br />
-		+	**[[5xk8]] – StUPP + GPP <br />
		+	**[[5xk6]] – StUPP + IPP <br />
		+	**[[5xk7]] – StUPP + DMAPP <br />
		+	**[[5xk9]] – StUPP + GSPP + DMAPP <br />
	}}		}}