User:Ann Taylor/CFTR - Revision history

Ann Taylor at 19:00, 15 April 2016

Ann Taylor — Fri, 15 Apr 2016 19:00:00 GMT

←Older revision		Revision as of 19:00, 15 April 2016
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	==CFTR==		==CFTR==
-	<StructureSection ~~load~~='~~CFTR_model.pdb~~' size='340' side='right' caption='Homology model of CFTR' scene=''>	+	<StructureSection scene='Model_structure' size='340' side='right' caption='Homology model of CFTR' scene=''>
-	The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a chloride transporter that when mutated, causes cystic fibrosis. The structure of CFTR has not been determined experimentally; the structures shown on this page are based on a model built at [http://swissmodel.expasy.org]/, using the multidrug resistance protein, pgp-1 (pdb code [[4f4c]], as a model. The protein has twelve membrane spanning helices and two nucleotide binding domains. Chloride transport is regulated by both ATP and cAMP.	+	The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a chloride transporter that when mutated, causes cystic fibrosis. The structure of CFTR has not been determined experimentally; the structures shown on this page are based on a model built at [http://swissmodel.expasy.org]/, using the multidrug resistance protein, pgp-1 (pdb code [[4f4c]], as a model. The protein has <scene name='72/728139/Transmembrane_section/1'>twelve membrane spanning helices</scene> and <scene name='72/728139/Nucleotide_binding_domains/1'>two nucleotide binding domains</scene>; this structure has a large <scene name='72/728139/Undefined_loop/1'>undefined loop</scene>. Chloride transport is regulated by both ATP and cAMP.<ref>PMID: 1718606</ref>

	Like most diseases, there is not a single unique mutation that leads to cystic fibrosis; rather, a wide variety of sequence alterations leads to varying disease severity.<ref>PMID: 7686820</ref> The most severe symptoms are seen in patients who do not express CFTR on the epithelial membranes, due to nonsense or frame shift mutations or splicing errors. There are also a number of mutations associated with errors in processing, including the most common mutation, F508del. Less severe symptoms are seen in patients with point mutations of <scene name='72/728139/Regulation_mutations/1'>glycines in the nucleotide binding domains</scene>; many of these changes are found in the loop regions. Changes in conduction are observed in patients with mutations of <scene name='72/728139/Arg_mutations/2'>arginines</scene> located in the membrane spanning domain that are associated with ion selectivity.		Like most diseases, there is not a single unique mutation that leads to cystic fibrosis; rather, a wide variety of sequence alterations leads to varying disease severity.<ref>PMID: 7686820</ref> The most severe symptoms are seen in patients who do not express CFTR on the epithelial membranes, due to nonsense or frame shift mutations or splicing errors. There are also a number of mutations associated with errors in processing, including the most common mutation, F508del. Less severe symptoms are seen in patients with point mutations of <scene name='72/728139/Regulation_mutations/1'>glycines in the nucleotide binding domains</scene>; many of these changes are found in the loop regions. Changes in conduction are observed in patients with mutations of <scene name='72/728139/Arg_mutations/2'>arginines</scene> located in the membrane spanning domain that are associated with ion selectivity.

Ann Taylor at 18:38, 15 April 2016

Ann Taylor — Fri, 15 Apr 2016 18:38:53 GMT

←Older revision		Revision as of 18:38, 15 April 2016
Line 1:		Line 1:
	==CFTR==		==CFTR==
	<StructureSection load='CFTR_model.pdb' size='340' side='right' caption='Homology model of CFTR' scene=''>		<StructureSection load='CFTR_model.pdb' size='340' side='right' caption='Homology model of CFTR' scene=''>
-	The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a chloride transporter that when mutated, causes cystic fibrosis.	+	The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a chloride transporter that when mutated, causes cystic fibrosis. The structure of CFTR has not been determined experimentally; the structures shown on this page are based on a model built at [http://swissmodel.expasy.org]/, using the multidrug resistance protein, pgp-1 (pdb code [[4f4c]], as a model. The protein has twelve membrane spanning helices and two nucleotide binding domains. Chloride transport is regulated by both ATP and cAMP.

-	~~== Function ==~~	+	Like most diseases, there is not a single unique mutation that leads to cystic fibrosis; rather, a wide variety of sequence alterations leads to varying disease severity.<ref>PMID: 7686820</ref> The most severe symptoms are seen in patients who do not express CFTR on the epithelial membranes, due to nonsense or frame shift mutations or splicing errors. There are also a number of mutations associated with errors in processing, including the most common mutation, F508del. Less severe symptoms are seen in patients with point mutations of <scene name='72/728139/Regulation_mutations/1'>glycines in the nucleotide binding domains</scene>; many of these changes are found in the loop regions. Changes in conduction are observed in patients with mutations of <scene name='72/728139/Arg_mutations/2'>arginines</scene> located in the membrane spanning domain that are associated with ion selectivity.
-		+
-	~~== Disease ==~~	+
-		+
-	~~== Relevance ==~~	+
-		+
-	~~== Structural highlights ==~~	+
-		+
-	~~This~~ is a ~~sample scene created with SAT~~ to <scene name="/12/~~3456/Sample~~/1">~~color~~</scene> ~~by Group, and another to make~~ <scene name=~~"/12~~/~~3456~~/~~Sample~~/2">~~a transparent representation~~</scene> of the ~~protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes~~.	+

	</StructureSection>		</StructureSection>
	== References ==		== References ==
	<references/>		<references/>

Ann Taylor: New page: ==CFTR== The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a chlo...

Ann Taylor — Wed, 13 Apr 2016 12:53:57 GMT

New page: ==CFTR== <StructureSection load='CFTR_model.pdb' size='340' side='right' caption='Homology model of CFTR' scene=''> The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a chlo...

New page

==CFTR==
<StructureSection load='CFTR_model.pdb' size='340' side='right' caption='Homology model of CFTR' scene=''>
The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a chloride transporter that when mutated, causes cystic fibrosis.

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>