David Solfiell: New page: {{STRUCTURE_1xtc| PDB=1xtc | SIZE=500| SCENE=Cholera_toxin/Cv/1 |right|CAPTION=Cholera toxin 1xtc }} Cholera toxin (CTX) from the bacterium ''Vibrio cholerae'' is an oligomeric...

David Solfiell — Wed, 07 Dec 2011 17:49:07 GMT

New page: {{STRUCTURE_1xtc| PDB=1xtc | SIZE=500| SCENE=Cholera_toxin/Cv/1 |right|CAPTION=Cholera toxin 1xtc }} Cholera toxin (CTX) from the bacterium ''Vibrio cholerae'' is an oligomeric...

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{{STRUCTURE_1xtc| PDB=1xtc | SIZE=500| SCENE=Cholera_toxin/Cv/1 |right|CAPTION=Cholera toxin [[1xtc]] }}

[[Cholera toxin]] (CTX) from the bacterium ''Vibrio cholerae'' is an oligomeric complex of an enzymatic subunit (chain A) and 5 copies of chain B which bind to the cell surface. The enzymatic subunit has a globular domain (CTA1) and a long helical domain (CTA2). Once the CTX binds to the cell surface, it is internalized, and its CTA1 domain binds to ADP-ribosylation factor 6 (Arf6) enabling its catalytic activity. The images at the left and at the right correspond to the crystal structure of cholera toxin ([[1xtc]]).

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== 3D Structures of Cholera toxin ==

''Updated November 2011''

=== CTX ===

[[1xtc]] - CTX

=== CTX A subunit ===

[[2a5d]], [[2a5g]] – CTX A subunit+hArf6+GTP – human 
[[2a5f]] - CTX A subunit+hArf6+GTP+NAD 
[[1s5b]], [[1s5c]], [[1s5d]], [[1s5e]], [[1s5f]] - CTX A subunit (mutant)

=== CTX B subunits ===

[[1fgb]] - CTX B subunits 
[[1g8z]] , [[1chp]], [[1chq]] - CTX B subunits (mutant) 
[[1rcv]], [[1rd9]], [[1rdp]], [[1rf2]], [[1pzi]], [[1pzj]], [[1pzk]], [[1efi]], [[1eef]], [[1djr]], [[1eei]] – CTX B subunits+ galactoside derivatives 
[[1llr]], [[1jqy]], [[1jr0]], [[1fd7]], [[1md2]] - CTX B subunits+BMSC derivatives 
[[1eef]] - CTX B subunits+PEPG 
[[3chb]], [[2chb]] - CTX B subunits+pentasaccharide 
[[1ct1]] - CTX B subunits (mutant)+pentasaccharide 
[[3efx]] – CTX B/heat-labile enterotoxin B chain 
[[1tet]] – CTX peptide 3+FAB light and heavy chains - mouse

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David Solfiell: New page: {{STRUCTURE_1xtc| PDB=1xtc | SIZE=500| SCENE=Cholera_toxin/Cv/1 |right|CAPTION=Cholera toxin 1xtc }} Cholera toxin (CTX) from the bacterium ''Vibrio cholerae'' is an oligomeric...