User:Eric Martz/MHC Quiz - Revision history

Eric Martz at 18:59, 14 July 2020

Eric Martz — Tue, 14 Jul 2020 18:59:50 GMT

←Older revision		Revision as of 18:59, 14 July 2020
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-	==~~Antibody~~ Quiz==	+	==MHC Quiz==

	You will get immediate feedback when you click ''Submit'' (at the bottom of the quiz). This quiz is offered to accompany the MHC structure tutorial at [http://molviz.org MolviZ.Org]. All the information needed to answer this quiz correctly is covered in that tutorial.		You will get immediate feedback when you click ''Submit'' (at the bottom of the quiz). This quiz is offered to accompany the MHC structure tutorial at [http://molviz.org MolviZ.Org]. All the information needed to answer this quiz correctly is covered in that tutorial.

Eric Martz at 18:59, 14 July 2020

Eric Martz — Tue, 14 Jul 2020 18:59:18 GMT

←Older revision		Revision as of 18:59, 14 July 2020
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	==Antibody Quiz==		==Antibody Quiz==

-	You will get immediate feedback when you click ''Submit'' (at the bottom of the quiz). This quiz is offered to accompany the MHC structure tutorial at [http://molviz.org MolviZ.Org].	+	You will get immediate feedback when you click ''Submit'' (at the bottom of the quiz). This quiz is offered to accompany the MHC structure tutorial at [http://molviz.org MolviZ.Org]. All the information needed to answer this quiz correctly is covered in that tutorial.

	<!-- (i) = case Insensitive. _7 = width of slot (number of characters) for answer. -->		<!-- (i) = case Insensitive. _7 = width of slot (number of characters) for answer. -->
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	- Red blood cells.		- Red blood cells.
	+ Liver cells.		+ Liver cells.
		+	+ Macrophages.
		+	+ Dendritic cells.
		+
		+	{Which kinds of cells express MHC class II?
		+	\|type="[]"}
		+	- T lymphocytes.
		+	- Red blood cells.
		+	- Liver cells.
	+ Macrophages.		+ Macrophages.
	+ Dendritic cells.		+ Dendritic cells.
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	{T lymphocytes examine		{T lymphocytes examine
	\|type="[]"}		\|type="[]"}
-	- Peptide side chains that are buried in the cleft.	+	- Peptide amino acid side chains that are buried in the cleft.
-	+ Peptide side chains that are exposed in the cleft.	+	+ Peptide amino acid side chains that are exposed in the cleft.
	+ Both MHC classes I and II.		+ Both MHC classes I and II.
	- Intact protein antigens.		- Intact protein antigens.
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	- The lysosome.		- The lysosome.

		+	{How many polypeptide chains make up an MHC class I molecule, not counting the antigenic peptide?
		+	\|type="{}"}
		+	{ 2\|two (i)\|two. (i) _7 }
		+	\|\|

		+	{How many polypeptide chains make up the MHC class I peptide-binding cleft, not counting the antigenic peptide?
		+	\|type="{}"}
		+	{ 1\|one (i)\|one. (i) _7 }
		+	\|\|

-	{How many polypeptide chains make up an MHC ~~Class I~~ molecule, not counting the antigenic peptide?	+	{How many polypeptide chains make up an MHC class II molecule, not counting the antigenic peptide?
	\|type="{}"}		\|type="{}"}
	{ 2\|two (i)\|two. (i) _7 }		{ 2\|two (i)\|two. (i) _7 }
	\|\|		\|\|

-	{How many polypeptide chains make up the MHC I peptide-binding cleft, not counting the antigenic peptide?	+	{How many polypeptide chains make up the MHC class II peptide-binding cleft, not counting the antigenic peptide?
	\|type="{}"}		\|type="{}"}
-	{ 1\|~~one~~ (i)\|~~one~~. (i) _7 }	+	{ 2\|two (i)\|two. (i) _7 }
	\|\|		\|\|

Eric Martz at 18:54, 14 July 2020

Eric Martz — Tue, 14 Jul 2020 18:54:45 GMT

←Older revision		Revision as of 18:54, 14 July 2020
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	+ Both MHC classes I and II.		+ Both MHC classes I and II.
	- Intact protein antigens.		- Intact protein antigens.
		+
		+	{Foreign peptides are distinguished from self peptides by:
		+	\|type="[]"}
		+	- MHC class I.
		+	+ CD4 T lymphocytes.
		+	+ CD8 T lymphocytes.
		+	- The proteasome.
		+	- The lysosome.
		+
		+

	{How many polypeptide chains make up an MHC Class I molecule, not counting the antigenic peptide?		{How many polypeptide chains make up an MHC Class I molecule, not counting the antigenic peptide?

Eric Martz at 18:44, 14 July 2020

Eric Martz — Tue, 14 Jul 2020 18:44:59 GMT

←Older revision		Revision as of 18:44, 14 July 2020
Line 74:		Line 74:
	\|type="[]"}		\|type="[]"}
	- Peptide side chains that are buried in the cleft.		- Peptide side chains that are buried in the cleft.
-	+ Peptide side chains that are exposed.	+	+ Peptide side chains that are exposed in the cleft.
	+ Both MHC classes I and II.		+ Both MHC classes I and II.
	- Intact protein antigens.		- Intact protein antigens.

Eric Martz at 18:43, 14 July 2020

Eric Martz — Tue, 14 Jul 2020 18:43:47 GMT

←Older revision		Revision as of 18:43, 14 July 2020
Line 75:		Line 75:
	- Peptide side chains that are buried in the cleft.		- Peptide side chains that are buried in the cleft.
	+ Peptide side chains that are exposed.		+ Peptide side chains that are exposed.
-	+ Both MHC classes.	+	+ Both MHC classes I and II.
		+	- Intact protein antigens.
		+
	{How many polypeptide chains make up an MHC Class I molecule, not counting the antigenic peptide?		{How many polypeptide chains make up an MHC Class I molecule, not counting the antigenic peptide?
	\|type="{}"}		\|type="{}"}

Eric Martz at 18:24, 14 July 2020

Eric Martz — Tue, 14 Jul 2020 18:24:00 GMT

←Older revision		Revision as of 18:24, 14 July 2020
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	{ 1\|one (i)\|one. (i) _7 }		{ 1\|one (i)\|one. (i) _7 }
	\|\|		\|\|
-
-
-
-	{<hr>'''An IgG1 molecule has a molecular weight of 150 kilo Daltons.'''}
-
-	{
-	\|type="{}"}
-	What is the approximate molecular weight of one immunoglobulin domain in kD?
-	{ 10-13 _7 } kD.
-	\|\|Twelve Ig domains in one IgG1 molecule. 150/12 = 12.5 kD.
-
-	{<hr>
-	'''Questions below may have <font color="red">more than one</font> correct answer.'''}
-
-	{Antibody
-	\|type="[]"}
-	+ Binds to antigen.
-	+ When bound to a microbe, recruits macrophages and other leukocytes to kill the microbes.
-	+ Defends us against infections.
-	- Carries oxygen to tissues.
-	- Is a hormone.
-	- Strengthens bones.
-	\|\|
-
-
-

Eric Martz at 23:27, 13 July 2020

Eric Martz — Mon, 13 Jul 2020 23:27:23 GMT

←Older revision		Revision as of 23:27, 13 July 2020
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	+ In MHC class I, binds only peptides with specific anchor residues.		+ In MHC class I, binds only peptides with specific anchor residues.

-		+	{T lymphocytes examine
		+	\|type="[]"}
		+	- Peptide side chains that are buried in the cleft.
		+	+ Peptide side chains that are exposed.
		+	+ Both MHC classes.
	{How many polypeptide chains make up an MHC Class I molecule, not counting the antigenic peptide?		{How many polypeptide chains make up an MHC Class I molecule, not counting the antigenic peptide?
	\|type="{}"}		\|type="{}"}

Eric Martz at 23:23, 13 July 2020

Eric Martz — Mon, 13 Jul 2020 23:23:43 GMT

←Older revision		Revision as of 23:23, 13 July 2020
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	- Is part of the MHC class II protein.		- Is part of the MHC class II protein.
	- Activates T cytotoxic cells.		- Activates T cytotoxic cells.
		+	- Is an anchor residue.

		+	{The peptide-binding cleft
		+	\|type="[]"}
		+	+ Has closed ends in MHC class I.
		+	- Has closed ends in MHC class II.
		+	- Has open ends in MHC class I.
		+	+ Has open ends in MHC class II.
		+	+ In MHC class I, binds only peptides with specific anchor residues.

Eric Martz at 23:19, 13 July 2020

Eric Martz — Mon, 13 Jul 2020 23:19:28 GMT

←Older revision		Revision as of 23:19, 13 July 2020
Line 53:		Line 53:
	- They are recycled by the lymphatic system.		- They are recycled by the lymphatic system.
	+ They lose their ability to activate CD8 T lymphocytes.		+ They lose their ability to activate CD8 T lymphocytes.
		+
		+	{Beta-2 microglobulin
		+	\|type="[]"}
		+	- Binds to CD8.
		+	- Has a peptide-binding cleft.
		+	+ Is part of the MHC class I protein.
		+	- Is part of the MHC class II protein.
		+	- Activates T cytotoxic cells.
		+

Eric Martz at 23:15, 13 July 2020

Eric Martz — Mon, 13 Jul 2020 23:15:17 GMT

←Older revision		Revision as of 23:15, 13 July 2020
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	- Removes worn out proteins.		- Removes worn out proteins.
	- It makes antibody.		- It makes antibody.
		+	+ It remains bound to the cell membrane.
		+	- It is released from cells to float freely and bind to CD8.
		+
		+	{Which kinds of cells express MHC class I?
		+	\|type="[]"}
		+	+ B lymphocytes.
		+	+ T lymphocytes.
		+	- Red blood cells.
		+	+ Liver cells.
		+	+ Macrophages.
		+	+ Dendritic cells.
		+
		+	{Why do some viruses impair the expression of MHC class I on their host cells?
		+	\|type="[]"}
		+	- To hide from Natural Killer Cells.
		+	+ To hide from CD8 cytotoxic T cells.
		+	- To attract CD4 helper T cells.
		+	- To conserve virus peptides.

	{What happens to cells that express little or no MHC class I?		{What happens to cells that express little or no MHC class I?