User:Fabian Romano/Sandbox 1 - Revision history

Fabian Romano at 22:11, 14 December 2010

Fabian Romano — Tue, 14 Dec 2010 22:11:54 GMT

←Older revision		Revision as of 22:11, 14 December 2010
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	caption='PcrH' />		caption='PcrH' />

-	PcrH ~~is a co-chaperone that binds and stabilizes bacterial toxins in their cytoplasm~~	+	== PcrH ==

-	<scene name='User:Fabian_Romano/Sandbox_1/Pcrh1/3'>~~PcrH~~</scene>	+	Many Gram-negative pathogens use a Type III secretion (T3S) system to inject effector proteins into the cytoplasm of their target cell. These effectors need to translocate through the plasma membrane, presumably through a proteinaceous structure, the translocon. Substantial genetic and biochemical data indicate the translocon is composed by two T3S proteins, in the case of ''Pseudomonas'' ''aeruginosa'', the translocators PopB and PopD.
		+	Since PopB and PopD can bind to lipid bilayers and form pores in them, they need to be maintained in a state competent for secretion and also not toxic for the bacterial cell. PrcH is a bacterial co-chaperone responsible for this. PcrH binds to a <scene name='User:Fabian_Romano/Sandbox_1/Pcrh1/3'>sequence motif</scene> present in both PopB and PopD and keeps them in a metastable non oligomeric state. Its also believed that PcrH has an active role in delivering PopB and PopD to the basal body of the T3S system, where an ATPse unfolds and secretes the translocators PopB and PopD.
		+	PcrH characteristic fold is composed of Tetratricopeptide Repeats (TPR repeats). This fold is also present in Eukaryotic co-chaperons such as HOP.

Fabian Romano — Tue, 14 Dec 2010 16:28:13 GMT

←Older revision		Revision as of 16:28, 14 December 2010
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	PcrH is a co-chaperone that binds and stabilizes bacterial toxins in their cytoplasm		PcrH is a co-chaperone that binds and stabilizes bacterial toxins in their cytoplasm

-	<scene name='User:Fabian_Romano/Sandbox_1/Pcrh1/3'>~~TextToBeDisplayed~~</scene>	+	<scene name='User:Fabian_Romano/Sandbox_1/Pcrh1/3'>PcrH</scene>

Fabian Romano — Tue, 14 Dec 2010 15:57:23 GMT

←Older revision		Revision as of 15:57, 14 December 2010
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	PcrH is a co-chaperone that binds and stabilizes bacterial toxins in their cytoplasm		PcrH is a co-chaperone that binds and stabilizes bacterial toxins in their cytoplasm

-	~~This is~~ <scene name='User:Fabian_Romano/Sandbox_1/~~Pcrh3~~/1'>~~PcrH~~</scene>	+	<scene name='User:Fabian_Romano/Sandbox_1/Pcrh1/3'>TextToBeDisplayed</scene>

Fabian Romano — Tue, 14 Dec 2010 15:45:29 GMT

←Older revision		Revision as of 15:45, 14 December 2010
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	PcrH is a co-chaperone that binds and stabilizes bacterial toxins in their cytoplasm		PcrH is a co-chaperone that binds and stabilizes bacterial toxins in their cytoplasm

-	This is <scene name='User:Fabian_Romano/Sandbox_1/~~Pcrh2~~/1'>PcrH</scene>	+	This is <scene name='User:Fabian_Romano/Sandbox_1/Pcrh3/1'>PcrH</scene>

Fabian Romano — Tue, 14 Dec 2010 15:29:47 GMT

←Older revision		Revision as of 15:29, 14 December 2010
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	PcrH is a co-chaperone that binds and stabilizes bacterial toxins in their cytoplasm		PcrH is a co-chaperone that binds and stabilizes bacterial toxins in their cytoplasm

-	This is <scene name='User:Fabian_Romano/Sandbox_1/~~Pcrh1~~/2'>PcrH</scene>	+	This is <scene name='User:Fabian_Romano/Sandbox_1/Pcrh2/1'>PcrH</scene>

Fabian Romano — Tue, 14 Dec 2010 15:11:59 GMT

←Older revision		Revision as of 15:11, 14 December 2010
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	PcrH is a co-chaperone that binds and stabilizes bacterial toxins in their cytoplasm		PcrH is a co-chaperone that binds and stabilizes bacterial toxins in their cytoplasm
-	This is <scene name='User:Fabian_Romano/Sandbox_1/Pcrh1/1'>~~TextToBeDisplayed~~</scene>	+
		+	This is <scene name='User:Fabian_Romano/Sandbox_1/Pcrh1/2'>PcrH</scene>

Fabian Romano — Tue, 14 Dec 2010 15:01:30 GMT

←Older revision		Revision as of 15:01, 14 December 2010
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	PcrH is a co-chaperone that binds and stabilizes bacterial toxins in their cytoplasm		PcrH is a co-chaperone that binds and stabilizes bacterial toxins in their cytoplasm
-	This is <scene name='User:Fabian_Romano/Sandbox_1/~~Pcrh-popd~~/1'>TextToBeDisplayed</scene>	+	This is <scene name='User:Fabian_Romano/Sandbox_1/Pcrh1/1'>TextToBeDisplayed</scene>

Fabian Romano — Tue, 14 Dec 2010 06:35:42 GMT

←Older revision		Revision as of 06:35, 14 December 2010
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	caption='PcrH' />		caption='PcrH' />

		+	PcrH is a co-chaperone that binds and stabilizes bacterial toxins in their cytoplasm
	This is <scene name='User:Fabian_Romano/Sandbox_1/Pcrh-popd/1'>TextToBeDisplayed</scene>		This is <scene name='User:Fabian_Romano/Sandbox_1/Pcrh-popd/1'>TextToBeDisplayed</scene>

Fabian Romano — Tue, 14 Dec 2010 06:34:47 GMT

←Older revision		Revision as of 06:34, 14 December 2010
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	caption='PcrH' />		caption='PcrH' />

-	This is <scene name='User:Fabian_Romano/Sandbox_1/~~PcrH bound to PopD fragment~~/1'>TextToBeDisplayed</scene>	+	This is <scene name='User:Fabian_Romano/Sandbox_1/Pcrh-popd/1'>TextToBeDisplayed</scene>

Fabian Romano — Tue, 14 Dec 2010 06:33:33 GMT

←Older revision		Revision as of 06:33, 14 December 2010
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	<applet size='[450,338]' load='2xcB' frame='true' align='right'		<applet size='[450,338]' load='2xcB' frame='true' align='right'
	caption='PcrH' />		caption='PcrH' />
		+
		+	This is <scene name='User:Fabian_Romano/Sandbox_1/PcrH bound to PopD fragment/1'>TextToBeDisplayed</scene>