User:Jing Huang/Sandbox 1 - Revision history

Jing Huang at 00:05, 21 December 2012

Jing Huang — Fri, 21 Dec 2012 00:05:58 GMT

←Older revision		Revision as of 00:05, 21 December 2012
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-	<scene name='User:Jing_Huang/Sandbox_1/Ligand/1'>Ligand</scene>

Jing Huang at 00:05, 21 December 2012

Jing Huang — Fri, 21 Dec 2012 00:05:15 GMT

←Older revision	Revision as of 00:05, 21 December 2012
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	+
	+	<scene name='User:Jing_Huang/Sandbox_1/Ligand/1'>Ligand</scene>

Jing Huang at 17:09, 14 December 2012

Jing Huang — Fri, 14 Dec 2012 17:09:07 GMT

←Older revision		Revision as of 17:09, 14 December 2012
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	One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground]		One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground]
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	----		----
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	[http://en.wikipedia.org/wiki/Anthrax_toxin Anthrax toxin] complex consists of three nontoxic proteins: protective antigen (<scene name='User:Jing_Huang/Sandbox_1/Pa-63/1'>PA</scene>), lethal factor ([http://en.wikipedia.org/wiki/Anthrax_lethal_factor_endopeptidase LF]), and endema factor (EF). PA forms pore and delivers LF and EF, which lead to lethal shock and edema of the host separately, to the cytosol. Formation of the toxin complex starts when PA binds to the cellular receptors and is cleaved into two fragments. The smaller fragment <scene name='User:Jing_Huang/Sandbox_1/Pa-20/1'>PA-20</scene> (20 kDa) dissociates and the remaining receptor-bound fragment <scene name='User:Jing_Huang/Sandbox_1/Pa-63/2'>PA-63</scene> (63 kDa) self-assemblies to a ring-shaped heptameric oligomer, a pore precursor (<scene name='User:Jing_Huang/Sandbox_1/Prepore/1'>prepore</scene>). LF and/or EF binds to the PA63 prepore to form a toxic complex. Oligomerization of PA-63 causes the endocytosis and the complex is trafficked to an acidic compartment. The PA-63 heptamer converts from the prepore to the pore state under a low pH condition and translocates LF/EF into the cell.		[http://en.wikipedia.org/wiki/Anthrax_toxin Anthrax toxin] complex consists of three nontoxic proteins: protective antigen (<scene name='User:Jing_Huang/Sandbox_1/Pa-63/1'>PA</scene>), lethal factor ([http://en.wikipedia.org/wiki/Anthrax_lethal_factor_endopeptidase LF]), and endema factor (EF). PA forms pore and delivers LF and EF, which lead to lethal shock and edema of the host separately, to the cytosol. Formation of the toxin complex starts when PA binds to the cellular receptors and is cleaved into two fragments. The smaller fragment <scene name='User:Jing_Huang/Sandbox_1/Pa-20/1'>PA-20</scene> (20 kDa) dissociates and the remaining receptor-bound fragment <scene name='User:Jing_Huang/Sandbox_1/Pa-63/2'>PA-63</scene> (63 kDa) self-assemblies to a ring-shaped heptameric oligomer, a pore precursor (<scene name='User:Jing_Huang/Sandbox_1/Prepore/1'>prepore</scene>). LF and/or EF binds to the PA63 prepore to form a toxic complex. Oligomerization of PA-63 causes the endocytosis and the complex is trafficked to an acidic compartment. The PA-63 heptamer converts from the prepore to the pore state under a low pH condition and translocates LF/EF into the cell.
		+
		+
		+
		+

Jing Huang at 17:08, 14 December 2012

Jing Huang — Fri, 14 Dec 2012 17:08:40 GMT

←Older revision		Revision as of 17:08, 14 December 2012
Line 1:		Line 1:
	One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground]		One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground]
	----		----
		+
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		+
	<table align="right" width="400" border="0" style="background-color:#e0e0e0;"><tr><td>		<table align="right" width="400" border="0" style="background-color:#e0e0e0;"><tr><td>
	<Structure load='1ACC' size='500' frame='true' align='right' caption='Anthrax Protective Atigen (PDB ID: [http://www.rcsb.org/pdb/explore/explore.do?structureId=1acc 1ACC]), PA-63 prepore (PDB ID: [http://www.rcsb.org/pdb/explore/explore.do?structureId=1TZO 1TZO])' scene='Insert optional scene name here' />		<Structure load='1ACC' size='500' frame='true' align='right' caption='Anthrax Protective Atigen (PDB ID: [http://www.rcsb.org/pdb/explore/explore.do?structureId=1acc 1ACC]), PA-63 prepore (PDB ID: [http://www.rcsb.org/pdb/explore/explore.do?structureId=1TZO 1TZO])' scene='Insert optional scene name here' />
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	[http://en.wikipedia.org/wiki/Anthrax_toxin Anthrax toxin] complex consists of three nontoxic proteins: protective antigen (<scene name='User:Jing_Huang/Sandbox_1/Pa-63/1'>PA</scene>), lethal factor ([http://en.wikipedia.org/wiki/Anthrax_lethal_factor_endopeptidase LF]), and endema factor (EF). PA forms pore and delivers LF and EF, which lead to lethal shock and edema of the host separately, to the cytosol. Formation of the toxin complex starts when PA binds to the cellular receptors and is cleaved into two fragments. The smaller fragment <scene name='User:Jing_Huang/Sandbox_1/Pa-20/1'>PA-20</scene> (20 kDa) dissociates and the remaining receptor-bound fragment <scene name='User:Jing_Huang/Sandbox_1/Pa-63/2'>PA-63</scene> (63 kDa) self-assemblies to a ring-shaped heptameric oligomer, a pore precursor (<scene name='User:Jing_Huang/Sandbox_1/Prepore/1'>prepore</scene>). LF and/or EF binds to the PA63 prepore to form a toxic complex. Oligomerization of PA-63 causes the endocytosis and the complex is trafficked to an acidic compartment. The PA-63 heptamer converts from the prepore to the pore state under a low pH condition and translocates LF/EF into the cell.		[http://en.wikipedia.org/wiki/Anthrax_toxin Anthrax toxin] complex consists of three nontoxic proteins: protective antigen (<scene name='User:Jing_Huang/Sandbox_1/Pa-63/1'>PA</scene>), lethal factor ([http://en.wikipedia.org/wiki/Anthrax_lethal_factor_endopeptidase LF]), and endema factor (EF). PA forms pore and delivers LF and EF, which lead to lethal shock and edema of the host separately, to the cytosol. Formation of the toxin complex starts when PA binds to the cellular receptors and is cleaved into two fragments. The smaller fragment <scene name='User:Jing_Huang/Sandbox_1/Pa-20/1'>PA-20</scene> (20 kDa) dissociates and the remaining receptor-bound fragment <scene name='User:Jing_Huang/Sandbox_1/Pa-63/2'>PA-63</scene> (63 kDa) self-assemblies to a ring-shaped heptameric oligomer, a pore precursor (<scene name='User:Jing_Huang/Sandbox_1/Prepore/1'>prepore</scene>). LF and/or EF binds to the PA63 prepore to form a toxic complex. Oligomerization of PA-63 causes the endocytosis and the complex is trafficked to an acidic compartment. The PA-63 heptamer converts from the prepore to the pore state under a low pH condition and translocates LF/EF into the cell.
		+
		+
		+

	= Reference =		= Reference =
	#R.John Collier and John A.T.Young. (2003) Anthrax Toxin., Annu. Rev. Cell Dev. Biol.19:45-70		#R.John Collier and John A.T.Young. (2003) Anthrax Toxin., Annu. Rev. Cell Dev. Biol.19:45-70

Jing Huang at 15:35, 13 December 2012

Jing Huang — Thu, 13 Dec 2012 15:35:35 GMT

←Older revision		Revision as of 15:35, 13 December 2012
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	= Protective Antigen =		= Protective Antigen =

-	[http://en.wikipedia.org/wiki/Anthrax_toxin Anthrax toxin] complex consists of three nontoxic proteins: protective antigen (<scene name='User:Jing_Huang/Sandbox_1/Pa-63/1'>PA</scene>), lethal factor ([http://en.wikipedia.org/wiki/Anthrax_lethal_factor_endopeptidase LF]), and endema factor (EF). PA forms pore and delivers LF and EF, which lead to lethal shock and edema of the host separately, to the cytosol. Formation of the toxin complex starts when PA binds to the cellular receptors and is cleaved into two fragments. The smaller fragment <scene name='User:Jing_Huang/Sandbox_1/Pa-20/1'>PA-20</scene> (20 kDa) dissociates and the remaining receptor-bound fragment <scene name='User:Jing_Huang/Sandbox_1/Pa-63/2'>PA-63</scene> (63 kDa) self-assemblies to a ring-shaped heptameric oligomer, a pore precursor (<scene name='User:Jing_Huang/Sandbox_1/Prepore/1'>prepore</scene>). LF and/or EF binds to the PA63 prepore to form a toxic complex. Oligomerization of PA-63 causes the endocytosis and the complex is trafficked to an acidic compartment. The PA-63 heptamer converts from the prepore to the pore state and translocates LF/EF into the cell.	+	[http://en.wikipedia.org/wiki/Anthrax_toxin Anthrax toxin] complex consists of three nontoxic proteins: protective antigen (<scene name='User:Jing_Huang/Sandbox_1/Pa-63/1'>PA</scene>), lethal factor ([http://en.wikipedia.org/wiki/Anthrax_lethal_factor_endopeptidase LF]), and endema factor (EF). PA forms pore and delivers LF and EF, which lead to lethal shock and edema of the host separately, to the cytosol. Formation of the toxin complex starts when PA binds to the cellular receptors and is cleaved into two fragments. The smaller fragment <scene name='User:Jing_Huang/Sandbox_1/Pa-20/1'>PA-20</scene> (20 kDa) dissociates and the remaining receptor-bound fragment <scene name='User:Jing_Huang/Sandbox_1/Pa-63/2'>PA-63</scene> (63 kDa) self-assemblies to a ring-shaped heptameric oligomer, a pore precursor (<scene name='User:Jing_Huang/Sandbox_1/Prepore/1'>prepore</scene>). LF and/or EF binds to the PA63 prepore to form a toxic complex. Oligomerization of PA-63 causes the endocytosis and the complex is trafficked to an acidic compartment. The PA-63 heptamer converts from the prepore to the pore state under a low pH condition and translocates LF/EF into the cell.

	= Reference =		= Reference =
	#R.John Collier and John A.T.Young. (2003) Anthrax Toxin., Annu. Rev. Cell Dev. Biol.19:45-70		#R.John Collier and John A.T.Young. (2003) Anthrax Toxin., Annu. Rev. Cell Dev. Biol.19:45-70

Jing Huang at 15:34, 13 December 2012

Jing Huang — Thu, 13 Dec 2012 15:34:01 GMT

←Older revision		Revision as of 15:34, 13 December 2012
Line 5:		Line 5:
	</td></tr></table>		</td></tr></table>

-	= ~~Anthrax~~ Protective Antigen =	+	= Protective Antigen =

	[http://en.wikipedia.org/wiki/Anthrax_toxin Anthrax toxin] complex consists of three nontoxic proteins: protective antigen (<scene name='User:Jing_Huang/Sandbox_1/Pa-63/1'>PA</scene>), lethal factor ([http://en.wikipedia.org/wiki/Anthrax_lethal_factor_endopeptidase LF]), and endema factor (EF). PA forms pore and delivers LF and EF, which lead to lethal shock and edema of the host separately, to the cytosol. Formation of the toxin complex starts when PA binds to the cellular receptors and is cleaved into two fragments. The smaller fragment <scene name='User:Jing_Huang/Sandbox_1/Pa-20/1'>PA-20</scene> (20 kDa) dissociates and the remaining receptor-bound fragment <scene name='User:Jing_Huang/Sandbox_1/Pa-63/2'>PA-63</scene> (63 kDa) self-assemblies to a ring-shaped heptameric oligomer, a pore precursor (<scene name='User:Jing_Huang/Sandbox_1/Prepore/1'>prepore</scene>). LF and/or EF binds to the PA63 prepore to form a toxic complex. Oligomerization of PA-63 causes the endocytosis and the complex is trafficked to an acidic compartment. The PA-63 heptamer converts from the prepore to the pore state and translocates LF/EF into the cell.		[http://en.wikipedia.org/wiki/Anthrax_toxin Anthrax toxin] complex consists of three nontoxic proteins: protective antigen (<scene name='User:Jing_Huang/Sandbox_1/Pa-63/1'>PA</scene>), lethal factor ([http://en.wikipedia.org/wiki/Anthrax_lethal_factor_endopeptidase LF]), and endema factor (EF). PA forms pore and delivers LF and EF, which lead to lethal shock and edema of the host separately, to the cytosol. Formation of the toxin complex starts when PA binds to the cellular receptors and is cleaved into two fragments. The smaller fragment <scene name='User:Jing_Huang/Sandbox_1/Pa-20/1'>PA-20</scene> (20 kDa) dissociates and the remaining receptor-bound fragment <scene name='User:Jing_Huang/Sandbox_1/Pa-63/2'>PA-63</scene> (63 kDa) self-assemblies to a ring-shaped heptameric oligomer, a pore precursor (<scene name='User:Jing_Huang/Sandbox_1/Prepore/1'>prepore</scene>). LF and/or EF binds to the PA63 prepore to form a toxic complex. Oligomerization of PA-63 causes the endocytosis and the complex is trafficked to an acidic compartment. The PA-63 heptamer converts from the prepore to the pore state and translocates LF/EF into the cell.

Jing Huang at 15:32, 13 December 2012

Jing Huang — Thu, 13 Dec 2012 15:32:22 GMT

←Older revision		Revision as of 15:32, 13 December 2012
Line 7:		Line 7:
	= Anthrax Protective Antigen =		= Anthrax Protective Antigen =

-	[http://en.wikipedia.org/wiki/Anthrax_toxin Anthrax toxin] complex consists of three nontoxic proteins: protective antigen (<scene name='User:Jing_Huang/Sandbox_1/Pa-63/1'>PA</scene>), lethal factor ([http://en.wikipedia.org/wiki/Anthrax_lethal_factor_endopeptidase LF]), and endema factor (EF). PA forms pore and delivers LF and EF, which lead to lethal shock and edema of the host separately, to the cytosol. Formation of the toxin complex starts when PA binds to the cellular receptors and is cleaved into two fragments. The smaller fragment <scene name='User:Jing_Huang/Sandbox_1/Pa-20/1'>PA-20</scene> (20 kDa) dissociates and the remaining receptor-bound fragment PA-63 (63 kDa) self-assemblies to a ring-shaped heptameric oligomer, a pore precursor (<scene name='User:Jing_Huang/Sandbox_1/Prepore/1'>prepore</scene>). LF and/or EF binds to the PA63 prepore to form a toxic complex. Oligomerization of PA-63 causes the endocytosis and the complex is trafficked to an acidic compartment. The PA-63 heptamer converts from the prepore to the pore state and translocates LF/EF into the cell.	+	[http://en.wikipedia.org/wiki/Anthrax_toxin Anthrax toxin] complex consists of three nontoxic proteins: protective antigen (<scene name='User:Jing_Huang/Sandbox_1/Pa-63/1'>PA</scene>), lethal factor ([http://en.wikipedia.org/wiki/Anthrax_lethal_factor_endopeptidase LF]), and endema factor (EF). PA forms pore and delivers LF and EF, which lead to lethal shock and edema of the host separately, to the cytosol. Formation of the toxin complex starts when PA binds to the cellular receptors and is cleaved into two fragments. The smaller fragment <scene name='User:Jing_Huang/Sandbox_1/Pa-20/1'>PA-20</scene> (20 kDa) dissociates and the remaining receptor-bound fragment <scene name='User:Jing_Huang/Sandbox_1/Pa-63/2'>PA-63</scene> (63 kDa) self-assemblies to a ring-shaped heptameric oligomer, a pore precursor (<scene name='User:Jing_Huang/Sandbox_1/Prepore/1'>prepore</scene>). LF and/or EF binds to the PA63 prepore to form a toxic complex. Oligomerization of PA-63 causes the endocytosis and the complex is trafficked to an acidic compartment. The PA-63 heptamer converts from the prepore to the pore state and translocates LF/EF into the cell.

	= Reference =		= Reference =
	#R.John Collier and John A.T.Young. (2003) Anthrax Toxin., Annu. Rev. Cell Dev. Biol.19:45-70		#R.John Collier and John A.T.Young. (2003) Anthrax Toxin., Annu. Rev. Cell Dev. Biol.19:45-70

Jing Huang at 15:30, 13 December 2012

Jing Huang — Thu, 13 Dec 2012 15:30:42 GMT

←Older revision		Revision as of 15:30, 13 December 2012
Line 1:		Line 1:
	One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground]		One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground]
	----		----
-	<table align="right" width="~~300~~" border="0" style="background-color:#e0e0e0;"><tr><td>	+	<table align="right" width="400" border="0" style="background-color:#e0e0e0;"><tr><td>
	<Structure load='1ACC' size='500' frame='true' align='right' caption='Anthrax Protective Atigen (PDB ID: [http://www.rcsb.org/pdb/explore/explore.do?structureId=1acc 1ACC]), PA-63 prepore (PDB ID: [http://www.rcsb.org/pdb/explore/explore.do?structureId=1TZO 1TZO])' scene='Insert optional scene name here' />		<Structure load='1ACC' size='500' frame='true' align='right' caption='Anthrax Protective Atigen (PDB ID: [http://www.rcsb.org/pdb/explore/explore.do?structureId=1acc 1ACC]), PA-63 prepore (PDB ID: [http://www.rcsb.org/pdb/explore/explore.do?structureId=1TZO 1TZO])' scene='Insert optional scene name here' />
	</td></tr></table>		</td></tr></table>

Jing Huang at 15:29, 13 December 2012

Jing Huang — Thu, 13 Dec 2012 15:29:29 GMT

←Older revision		Revision as of 15:29, 13 December 2012
Line 7:		Line 7:
	= Anthrax Protective Antigen =		= Anthrax Protective Antigen =

-	[http://en.wikipedia.org/wiki/Anthrax_toxin Anthrax toxin] complex consists of three nontoxic proteins: protective antigen (<scene name='User:Jing_Huang/Sandbox_1/Pa-63/1'>PA</scene>), lethal factor ([http://en.wikipedia.org/wiki/Anthrax_lethal_factor_endopeptidase LF]), and endema factor (EF). PA forms pore and delivers LF and EF, which lead to lethal shock and edema of the host separately, to the cytosol. Formation of the toxin complex starts when PA binds to the cellular receptors and is cleaved into two fragments. The smaller fragment PA-20 (20 kDa) dissociates and the remaining receptor-bound fragment PA-63 (63 kDa) self-assemblies to a ring-shaped heptameric oligomer, a pore precursor (<scene name='User:Jing_Huang/Sandbox_1/Prepore/1'>prepore</scene>). LF and/or EF binds to the PA63 prepore to form a toxic complex. Oligomerization of PA-63 causes the endocytosis and the complex is trafficked to an acidic compartment. The PA-63 heptamer converts from the prepore to the pore state and translocates LF/EF into the cell.	+	[http://en.wikipedia.org/wiki/Anthrax_toxin Anthrax toxin] complex consists of three nontoxic proteins: protective antigen (<scene name='User:Jing_Huang/Sandbox_1/Pa-63/1'>PA</scene>), lethal factor ([http://en.wikipedia.org/wiki/Anthrax_lethal_factor_endopeptidase LF]), and endema factor (EF). PA forms pore and delivers LF and EF, which lead to lethal shock and edema of the host separately, to the cytosol. Formation of the toxin complex starts when PA binds to the cellular receptors and is cleaved into two fragments. The smaller fragment <scene name='User:Jing_Huang/Sandbox_1/Pa-20/1'>PA-20</scene> (20 kDa) dissociates and the remaining receptor-bound fragment PA-63 (63 kDa) self-assemblies to a ring-shaped heptameric oligomer, a pore precursor (<scene name='User:Jing_Huang/Sandbox_1/Prepore/1'>prepore</scene>). LF and/or EF binds to the PA63 prepore to form a toxic complex. Oligomerization of PA-63 causes the endocytosis and the complex is trafficked to an acidic compartment. The PA-63 heptamer converts from the prepore to the pore state and translocates LF/EF into the cell.

	= Reference =		= Reference =
-	#R.John Collier and John A.T.Young. (2003)Anthrax Toxin., Annu. Rev. Cell Dev. Biol.19:45-70	+	#R.John Collier and John A.T.Young. (2003) Anthrax Toxin., Annu. Rev. Cell Dev. Biol.19:45-70

Jing Huang at 15:24, 13 December 2012

Jing Huang — Thu, 13 Dec 2012 15:24:24 GMT

←Older revision		Revision as of 15:24, 13 December 2012
Line 1:		Line 1:
		+	One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground]
		+	----
	<table align="right" width="300" border="0" style="background-color:#e0e0e0;"><tr><td>		<table align="right" width="300" border="0" style="background-color:#e0e0e0;"><tr><td>
	<Structure load='1ACC' size='500' frame='true' align='right' caption='Anthrax Protective Atigen (PDB ID: [http://www.rcsb.org/pdb/explore/explore.do?structureId=1acc 1ACC]), PA-63 prepore (PDB ID: [http://www.rcsb.org/pdb/explore/explore.do?structureId=1TZO 1TZO])' scene='Insert optional scene name here' />		<Structure load='1ACC' size='500' frame='true' align='right' caption='Anthrax Protective Atigen (PDB ID: [http://www.rcsb.org/pdb/explore/explore.do?structureId=1acc 1ACC]), PA-63 prepore (PDB ID: [http://www.rcsb.org/pdb/explore/explore.do?structureId=1TZO 1TZO])' scene='Insert optional scene name here' />
Line 7:		Line 9:
	[http://en.wikipedia.org/wiki/Anthrax_toxin Anthrax toxin] complex consists of three nontoxic proteins: protective antigen (<scene name='User:Jing_Huang/Sandbox_1/Pa-63/1'>PA</scene>), lethal factor ([http://en.wikipedia.org/wiki/Anthrax_lethal_factor_endopeptidase LF]), and endema factor (EF). PA forms pore and delivers LF and EF, which lead to lethal shock and edema of the host separately, to the cytosol. Formation of the toxin complex starts when PA binds to the cellular receptors and is cleaved into two fragments. The smaller fragment PA-20 (20 kDa) dissociates and the remaining receptor-bound fragment PA-63 (63 kDa) self-assemblies to a ring-shaped heptameric oligomer, a pore precursor (<scene name='User:Jing_Huang/Sandbox_1/Prepore/1'>prepore</scene>). LF and/or EF binds to the PA63 prepore to form a toxic complex. Oligomerization of PA-63 causes the endocytosis and the complex is trafficked to an acidic compartment. The PA-63 heptamer converts from the prepore to the pore state and translocates LF/EF into the cell.		[http://en.wikipedia.org/wiki/Anthrax_toxin Anthrax toxin] complex consists of three nontoxic proteins: protective antigen (<scene name='User:Jing_Huang/Sandbox_1/Pa-63/1'>PA</scene>), lethal factor ([http://en.wikipedia.org/wiki/Anthrax_lethal_factor_endopeptidase LF]), and endema factor (EF). PA forms pore and delivers LF and EF, which lead to lethal shock and edema of the host separately, to the cytosol. Formation of the toxin complex starts when PA binds to the cellular receptors and is cleaved into two fragments. The smaller fragment PA-20 (20 kDa) dissociates and the remaining receptor-bound fragment PA-63 (63 kDa) self-assemblies to a ring-shaped heptameric oligomer, a pore precursor (<scene name='User:Jing_Huang/Sandbox_1/Prepore/1'>prepore</scene>). LF and/or EF binds to the PA63 prepore to form a toxic complex. Oligomerization of PA-63 causes the endocytosis and the complex is trafficked to an acidic compartment. The PA-63 heptamer converts from the prepore to the pore state and translocates LF/EF into the cell.

-	~~<scene name~~=~~'User~~:~~Jing_Huang/Sandbox_1/Prepore/1'>prepore</scene>~~	+	= Reference =
		+	#R.John Collier and John A.T.Young. (2003)Anthrax Toxin., Annu. Rev. Cell Dev. Biol.19:45-70