http://52.214.119.220/wiki/index.php?title=User:Riki_Stevenson/Sandbox_1&action=history Revision history for this page on the wiki en MediaWiki 1.11.2 Thu, 16 Apr 2026 02:39:47 GMT http://52.214.119.220/wiki/index.php?title=User:Riki_Stevenson/Sandbox_1&diff=951629&oldid=prev <p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 16:37, 29 April 2009</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 8:</td> <td colspan="2" class="diff-lineno">Line 8:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>(above info taken directly from the GCSF &lt;ref&gt;http://en.wikipedia.org/wiki/Granulocyte_colony-stimulating_factor&lt;/ref&gt; wiki page)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>(above info taken directly from the GCSF &lt;ref&gt;http://en.wikipedia.org/wiki/Granulocyte_colony-stimulating_factor&lt;/ref&gt; wiki page)</div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>&lt;scene name='User:Riki_Stevenson/Sandbox_1/Polar_and_hydrophobic_regions/1'&gt;HI&lt;/scene&gt;</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structure ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structure ==</div></td></tr> </table> Wed, 29 Apr 2009 16:37:35 GMT Riki Stevenson http://52.214.119.220/wiki/index.php/User_talk:Riki_Stevenson/Sandbox_1 http://52.214.119.220/wiki/index.php?title=User:Riki_Stevenson/Sandbox_1&diff=951479&oldid=prev <p><span class="autocomment">Structure</span></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 21:57, 27 April 2009</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 14:</td> <td colspan="2" class="diff-lineno">Line 14:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>&lt;scene name='User:Riki_Stevenson/Sandbox_1/Secondary_structure_from_top/1'&gt;The same elements&lt;/scene&gt; seen from the top view.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>&lt;scene name='User:Riki_Stevenson/Sandbox_1/Secondary_structure_from_top/1'&gt;The same elements&lt;/scene&gt; seen from the top view.</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>When structures are colored by &lt;scene name='User:Riki_Stevenson/Sandbox_1/Temperature_factors/1'&gt; temperature factors&lt;/scene&gt;, it accentuates regions of structural movement <del style="color: red; font-weight: bold; text-decoration: none;">and least fixed</del>. </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>When structures are colored by &lt;scene name='User:Riki_Stevenson/Sandbox_1/Temperature_factors/1'&gt; temperature factors&lt;/scene&gt;, it accentuates regions of structural movement. </div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>&lt;scene name='User:Riki_Stevenson/Sandbox_1/Polar_and_hydrophobic_regions/1'&gt;Polar and hydrophobic regions &lt;/scene&gt; (purple/grey) show how charged residues tend to congregate on the exterior of the structure.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>&lt;scene name='User:Riki_Stevenson/Sandbox_1/Polar_and_hydrophobic_regions/1'&gt;Polar and hydrophobic regions &lt;/scene&gt; (purple/grey) show how charged residues tend to congregate on the exterior of the structure.</div></td></tr> </table> Mon, 27 Apr 2009 21:57:24 GMT Riki Stevenson http://52.214.119.220/wiki/index.php/User_talk:Riki_Stevenson/Sandbox_1 http://52.214.119.220/wiki/index.php?title=User:Riki_Stevenson/Sandbox_1&diff=951477&oldid=prev <p><span class="autocomment">'''Granulocyte colony-stimulating factor (G-CSF or GCSF)'''</span></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 21:49, 27 April 2009</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 3:</td> <td colspan="2" class="diff-lineno">Line 3:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>is a colony-stimulating factor hormone. It is a glycoprotein, growth factor or cytokine produced by a number of different tissues to stimulate the bone marrow to produce granulocytes and stem cells. G-CSF then stimulates the bone marrow to release them into the blood. It also stimulates the survival, proliferation, differentiation, and function of neutrophil precursors and mature neutrophils. G-CSF is also known as colony-stimulating factor 3 (CSF 3).'''</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>is a colony-stimulating factor hormone. It is a glycoprotein, growth factor or cytokine produced by a number of different tissues to stimulate the bone marrow to produce granulocytes and stem cells. G-CSF then stimulates the bone marrow to release them into the blood. It also stimulates the survival, proliferation, differentiation, and function of neutrophil precursors and mature neutrophils. G-CSF is also known as colony-stimulating factor 3 (CSF 3).'''</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>It was first marketed by Amgen with the brand name <del style="color: red; font-weight: bold; text-decoration: none;">[http://en.wikipedia.org/wiki/</del>Neupogen<del style="color: red; font-weight: bold; text-decoration: none;">]</del>.Several bio-generic versions are now available in non regulated and semi-regulated countries.</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>It was first marketed by Amgen with the brand name Neupogen. <ins style="color: red; font-weight: bold; text-decoration: none;"> </ins>Several bio-generic versions are now available in non regulated and semi-regulated countries.</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The recombinant human G-CSF synthesised in an E. coli expression system is called [[filgrastim]]. The structure of filgrastim differs slightly from the structure of the natural glycoprotein. Most published studies have used filgrastim. Filgrastim (Neupogen) and PEG-filgrastim (Neulasta) are two commercially-available forms of rhG-CSF (recombinant human G-CSF). The PEG (polyethylene glycol) form has a much longer half-life, reducing the necessity of daily injections.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The recombinant human G-CSF synthesised in an E. coli expression system is called [[filgrastim]]. The structure of filgrastim differs slightly from the structure of the natural glycoprotein. Most published studies have used filgrastim. Filgrastim (Neupogen) and PEG-filgrastim (Neulasta) are two commercially-available forms of rhG-CSF (recombinant human G-CSF). The PEG (polyethylene glycol) form has a much longer half-life, reducing the necessity of daily injections.</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>(above info taken directly from the <del style="color: red; font-weight: bold; text-decoration: none;">[</del>http://en.wikipedia.org/wiki/Granulocyte_colony-stimulating_factor<del style="color: red; font-weight: bold; text-decoration: none;">] </del>wiki page)</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>(above info taken directly from the <ins style="color: red; font-weight: bold; text-decoration: none;">GCSF &lt;ref&gt;</ins>http://en.wikipedia.org/wiki/Granulocyte_colony-stimulating_factor<ins style="color: red; font-weight: bold; text-decoration: none;">&lt;/ref&gt; </ins>wiki page)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structure ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structure ==</div></td></tr> </table> Mon, 27 Apr 2009 21:49:08 GMT Riki Stevenson http://52.214.119.220/wiki/index.php/User_talk:Riki_Stevenson/Sandbox_1 http://52.214.119.220/wiki/index.php?title=User:Riki_Stevenson/Sandbox_1&diff=951475&oldid=prev <p><span class="autocomment">'''Granulocyte colony-stimulating factor (G-CSF or GCSF)'''</span></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 21:45, 27 April 2009</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 3:</td> <td colspan="2" class="diff-lineno">Line 3:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>is a colony-stimulating factor hormone. It is a glycoprotein, growth factor or cytokine produced by a number of different tissues to stimulate the bone marrow to produce granulocytes and stem cells. G-CSF then stimulates the bone marrow to release them into the blood. It also stimulates the survival, proliferation, differentiation, and function of neutrophil precursors and mature neutrophils. G-CSF is also known as colony-stimulating factor 3 (CSF 3).'''</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>is a colony-stimulating factor hormone. It is a glycoprotein, growth factor or cytokine produced by a number of different tissues to stimulate the bone marrow to produce granulocytes and stem cells. G-CSF then stimulates the bone marrow to release them into the blood. It also stimulates the survival, proliferation, differentiation, and function of neutrophil precursors and mature neutrophils. G-CSF is also known as colony-stimulating factor 3 (CSF 3).'''</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>It was first marketed by Amgen with the brand name <del style="color: red; font-weight: bold; text-decoration: none;">[</del>[http://en.wikipedia.org/wiki/Neupogen<del style="color: red; font-weight: bold; text-decoration: none;">]</del>].Several bio-generic versions are now available in non regulated and semi-regulated countries.</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>It was first marketed by Amgen with the brand name [http://en.wikipedia.org/wiki/Neupogen].Several bio-generic versions are now available in non regulated and semi-regulated countries.</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The recombinant human G-CSF synthesised in an E. coli expression system is called [[filgrastim]]. The structure of filgrastim differs slightly from the structure of the natural glycoprotein. Most published studies have used filgrastim. Filgrastim (Neupogen) and PEG-filgrastim (Neulasta) are two commercially-available forms of rhG-CSF (recombinant human G-CSF). The PEG (polyethylene glycol) form has a much longer half-life, reducing the necessity of daily injections.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The recombinant human G-CSF synthesised in an E. coli expression system is called [[filgrastim]]. The structure of filgrastim differs slightly from the structure of the natural glycoprotein. Most published studies have used filgrastim. Filgrastim (Neupogen) and PEG-filgrastim (Neulasta) are two commercially-available forms of rhG-CSF (recombinant human G-CSF). The PEG (polyethylene glycol) form has a much longer half-life, reducing the necessity of daily injections.</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>(above info taken directly from the <del style="color: red; font-weight: bold; text-decoration: none;">[</del>[http://en.wikipedia.org/wiki/Granulocyte_colony-stimulating_factor<del style="color: red; font-weight: bold; text-decoration: none;">]</del>] wiki page)</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>(above info taken directly from the [http://en.wikipedia.org/wiki/Granulocyte_colony-stimulating_factor] wiki page)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structure ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structure ==</div></td></tr> </table> Mon, 27 Apr 2009 21:45:30 GMT Riki Stevenson http://52.214.119.220/wiki/index.php/User_talk:Riki_Stevenson/Sandbox_1 http://52.214.119.220/wiki/index.php?title=User:Riki_Stevenson/Sandbox_1&diff=951474&oldid=prev <p><span class="autocomment">'''Granulocyte colony-stimulating factor (G-CSF or GCSF)'''</span></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 21:44, 27 April 2009</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 3:</td> <td colspan="2" class="diff-lineno">Line 3:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>is a colony-stimulating factor hormone. It is a glycoprotein, growth factor or cytokine produced by a number of different tissues to stimulate the bone marrow to produce granulocytes and stem cells. G-CSF then stimulates the bone marrow to release them into the blood. It also stimulates the survival, proliferation, differentiation, and function of neutrophil precursors and mature neutrophils. G-CSF is also known as colony-stimulating factor 3 (CSF 3).'''</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>is a colony-stimulating factor hormone. It is a glycoprotein, growth factor or cytokine produced by a number of different tissues to stimulate the bone marrow to produce granulocytes and stem cells. G-CSF then stimulates the bone marrow to release them into the blood. It also stimulates the survival, proliferation, differentiation, and function of neutrophil precursors and mature neutrophils. G-CSF is also known as colony-stimulating factor 3 (CSF 3).'''</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>It was first marketed by Amgen with the brand name [[Neupogen]]. Several bio-generic versions are now available in non regulated and semi-regulated countries.</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>It was first marketed by Amgen with the brand name [[<ins style="color: red; font-weight: bold; text-decoration: none;">http://en.wikipedia.org/wiki/</ins>Neupogen]].Several bio-generic versions are now available in non regulated and semi-regulated countries.</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The recombinant human G-CSF synthesised in an E. coli expression system is called [[filgrastim]]. The structure of filgrastim differs slightly from the structure of the natural glycoprotein. Most published studies have used filgrastim. Filgrastim (Neupogen) and PEG-filgrastim (Neulasta) are two commercially-available forms of rhG-CSF (recombinant human G-CSF). The PEG (polyethylene glycol) form has a much longer half-life, reducing the necessity of daily injections.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The recombinant human G-CSF synthesised in an E. coli expression system is called [[filgrastim]]. The structure of filgrastim differs slightly from the structure of the natural glycoprotein. Most published studies have used filgrastim. Filgrastim (Neupogen) and PEG-filgrastim (Neulasta) are two commercially-available forms of rhG-CSF (recombinant human G-CSF). The PEG (polyethylene glycol) form has a much longer half-life, reducing the necessity of daily injections.</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>(above info taken directly from the <del style="color: red; font-weight: bold; text-decoration: none;">[</del>[[http://en.wikipedia.org/wiki/Granulocyte_colony-stimulating_factor<del style="color: red; font-weight: bold; text-decoration: none;">]</del>]] wiki page)</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>(above info taken directly from the [[http://en.wikipedia.org/wiki/Granulocyte_colony-stimulating_factor]] wiki page)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structure ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structure ==</div></td></tr> </table> Mon, 27 Apr 2009 21:44:00 GMT Riki Stevenson http://52.214.119.220/wiki/index.php/User_talk:Riki_Stevenson/Sandbox_1 http://52.214.119.220/wiki/index.php?title=User:Riki_Stevenson/Sandbox_1&diff=951472&oldid=prev <p><span class="autocomment">'''Granulocyte colony-stimulating factor (G-CSF or GCSF)'''</span></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 21:36, 27 April 2009</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 7:</td> <td colspan="2" class="diff-lineno">Line 7:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The recombinant human G-CSF synthesised in an E. coli expression system is called [[filgrastim]]. The structure of filgrastim differs slightly from the structure of the natural glycoprotein. Most published studies have used filgrastim. Filgrastim (Neupogen) and PEG-filgrastim (Neulasta) are two commercially-available forms of rhG-CSF (recombinant human G-CSF). The PEG (polyethylene glycol) form has a much longer half-life, reducing the necessity of daily injections.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The recombinant human G-CSF synthesised in an E. coli expression system is called [[filgrastim]]. The structure of filgrastim differs slightly from the structure of the natural glycoprotein. Most published studies have used filgrastim. Filgrastim (Neupogen) and PEG-filgrastim (Neulasta) are two commercially-available forms of rhG-CSF (recombinant human G-CSF). The PEG (polyethylene glycol) form has a much longer half-life, reducing the necessity of daily injections.</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>(above info taken directly from the [[<del style="color: red; font-weight: bold; text-decoration: none;">GCSF</del>]] wiki page)</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>(above info taken directly from the [[<ins style="color: red; font-weight: bold; text-decoration: none;">[http://en.wikipedia.org/wiki/Granulocyte_colony-stimulating_factor]</ins>]] wiki page)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structure ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structure ==</div></td></tr> </table> Mon, 27 Apr 2009 21:36:04 GMT Riki Stevenson http://52.214.119.220/wiki/index.php/User_talk:Riki_Stevenson/Sandbox_1 http://52.214.119.220/wiki/index.php?title=User:Riki_Stevenson/Sandbox_1&diff=951471&oldid=prev <p><span class="autocomment">'''Granulocyte colony-stimulating factor (G-CSF or GCSF)'''</span></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 21:34, 27 April 2009</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 7:</td> <td colspan="2" class="diff-lineno">Line 7:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The recombinant human G-CSF synthesised in an E. coli expression system is called [[filgrastim]]. The structure of filgrastim differs slightly from the structure of the natural glycoprotein. Most published studies have used filgrastim. Filgrastim (Neupogen) and PEG-filgrastim (Neulasta) are two commercially-available forms of rhG-CSF (recombinant human G-CSF). The PEG (polyethylene glycol) form has a much longer half-life, reducing the necessity of daily injections.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The recombinant human G-CSF synthesised in an E. coli expression system is called [[filgrastim]]. The structure of filgrastim differs slightly from the structure of the natural glycoprotein. Most published studies have used filgrastim. Filgrastim (Neupogen) and PEG-filgrastim (Neulasta) are two commercially-available forms of rhG-CSF (recombinant human G-CSF). The PEG (polyethylene glycol) form has a much longer half-life, reducing the necessity of daily injections.</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>(above info taken directly from the [[<del style="color: red; font-weight: bold; text-decoration: none;">http://en.wikipedia.org/wiki/Granulocyte_colony-stimulating_factor|</del>GCSF]] wiki page)</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>(above info taken directly from the [[GCSF]] wiki page)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structure ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structure ==</div></td></tr> </table> Mon, 27 Apr 2009 21:34:44 GMT Riki Stevenson http://52.214.119.220/wiki/index.php/User_talk:Riki_Stevenson/Sandbox_1 http://52.214.119.220/wiki/index.php?title=User:Riki_Stevenson/Sandbox_1&diff=951468&oldid=prev <p><span class="autocomment">'''Granulocyte colony-stimulating factor (G-CSF or GCSF)'''</span></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 21:30, 27 April 2009</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 7:</td> <td colspan="2" class="diff-lineno">Line 7:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The recombinant human G-CSF synthesised in an E. coli expression system is called [[filgrastim]]. The structure of filgrastim differs slightly from the structure of the natural glycoprotein. Most published studies have used filgrastim. Filgrastim (Neupogen) and PEG-filgrastim (Neulasta) are two commercially-available forms of rhG-CSF (recombinant human G-CSF). The PEG (polyethylene glycol) form has a much longer half-life, reducing the necessity of daily injections.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The recombinant human G-CSF synthesised in an E. coli expression system is called [[filgrastim]]. The structure of filgrastim differs slightly from the structure of the natural glycoprotein. Most published studies have used filgrastim. Filgrastim (Neupogen) and PEG-filgrastim (Neulasta) are two commercially-available forms of rhG-CSF (recombinant human G-CSF). The PEG (polyethylene glycol) form has a much longer half-life, reducing the necessity of daily injections.</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>(above info taken directly from the [[<del style="color: red; font-weight: bold; text-decoration: none;">Granulocyte colony</del>-<del style="color: red; font-weight: bold; text-decoration: none;">stimulating factor</del>|GCSF]] wiki page)</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>(above info taken directly from the [[<ins style="color: red; font-weight: bold; text-decoration: none;">http://en.wikipedia.org/wiki/Granulocyte_colony</ins>-<ins style="color: red; font-weight: bold; text-decoration: none;">stimulating_factor</ins>|GCSF]] wiki page)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structure ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structure ==</div></td></tr> </table> Mon, 27 Apr 2009 21:30:52 GMT Riki Stevenson http://52.214.119.220/wiki/index.php/User_talk:Riki_Stevenson/Sandbox_1 http://52.214.119.220/wiki/index.php?title=User:Riki_Stevenson/Sandbox_1&diff=951467&oldid=prev <p><span class="autocomment">'''Granulocyte colony-stimulating factor (G-CSF or GCSF)'''</span></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 21:29, 27 April 2009</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 7:</td> <td colspan="2" class="diff-lineno">Line 7:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The recombinant human G-CSF synthesised in an E. coli expression system is called [[filgrastim]]. The structure of filgrastim differs slightly from the structure of the natural glycoprotein. Most published studies have used filgrastim. Filgrastim (Neupogen) and PEG-filgrastim (Neulasta) are two commercially-available forms of rhG-CSF (recombinant human G-CSF). The PEG (polyethylene glycol) form has a much longer half-life, reducing the necessity of daily injections.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The recombinant human G-CSF synthesised in an E. coli expression system is called [[filgrastim]]. The structure of filgrastim differs slightly from the structure of the natural glycoprotein. Most published studies have used filgrastim. Filgrastim (Neupogen) and PEG-filgrastim (Neulasta) are two commercially-available forms of rhG-CSF (recombinant human G-CSF). The PEG (polyethylene glycol) form has a much longer half-life, reducing the necessity of daily injections.</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>(above info taken directly from the [[GCSF]] wiki page)</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>(above info taken directly from the [[<ins style="color: red; font-weight: bold; text-decoration: none;">Granulocyte colony-stimulating factor|</ins>GCSF]] wiki page)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structure ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structure ==</div></td></tr> </table> Mon, 27 Apr 2009 21:29:26 GMT Riki Stevenson http://52.214.119.220/wiki/index.php/User_talk:Riki_Stevenson/Sandbox_1 http://52.214.119.220/wiki/index.php?title=User:Riki_Stevenson/Sandbox_1&diff=951466&oldid=prev <p><span class="autocomment">'''Granulocyte colony-stimulating factor (G-CSF or GCSF)'''</span></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 21:27, 27 April 2009</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"></td><td colspan="2">&nbsp;</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== '''Granulocyte colony-stimulating factor (G-CSF or GCSF)''' ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== '''Granulocyte colony-stimulating factor (G-CSF or GCSF)''' ==</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> &lt;applet load='1rhg' size='300' frame='true' align='right' caption='Insert caption here' /&gt;</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> &lt;applet load='1rhg' size='300' frame='true' align='right' caption='Insert caption here' /&gt;</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>is a colony-stimulating factor hormone. It is a glycoprotein, growth factor or cytokine produced by a number of different tissues to stimulate the bone marrow to produce granulocytes and stem cells. G-CSF then stimulates the bone marrow to release them into the blood. It also stimulates the survival, proliferation, differentiation, and function of neutrophil precursors and mature neutrophils. G-CSF is also known as colony-stimulating factor 3 (CSF 3).'''</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>is a colony-stimulating factor hormone. It is a glycoprotein, growth factor or cytokine produced by a number of different tissues to stimulate the bone marrow to produce granulocytes and stem cells. G-CSF then stimulates the bone marrow to release them into the blood. It also stimulates the survival, proliferation, differentiation, and function of neutrophil precursors and mature neutrophils. G-CSF is also known as colony-stimulating factor 3 (CSF 3).'''</div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>It was first marketed by Amgen with the brand name [[Neupogen]]. Several bio-generic versions are now available in non regulated and semi-regulated countries.</div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>The recombinant human G-CSF synthesised in an E. coli expression system is called [[filgrastim]]. The structure of filgrastim differs slightly from the structure of the natural glycoprotein. Most published studies have used filgrastim. Filgrastim (Neupogen) and PEG-filgrastim (Neulasta) are two commercially-available forms of rhG-CSF (recombinant human G-CSF). The PEG (polyethylene glycol) form has a much longer half-life, reducing the necessity of daily injections.</div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>(above info taken directly from the [[GCSF]] wiki page)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structure ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structure ==</div></td></tr> </table> Mon, 27 Apr 2009 21:27:31 GMT Riki Stevenson http://52.214.119.220/wiki/index.php/User_talk:Riki_Stevenson/Sandbox_1