Dipeptidyl Peptidase-4 Inhibitor Pharmacokinetics

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Revision as of 08:33, 13 December 2010

DPP4 Inhibitor Pharmacokinetics
Parameter	Vildagliptin (Galvus)	Sitagliptin (Januvia)	Saxagliptin (Onglyza)
Tmax (hr)	1.75	1-4	2
Cmax (ng/ml)	Vildagliptin (Galvus)	Sitagliptin (Januvia)	Saxagliptin (Onglyza)
Bioavailability (%)	85	87	67
Protein Binding (%)	9	38	0
T1/2 (hr)	2-3	12.4	2.5
AUC (ng/ml/hr)	Vildagliptin (Galvus)	Sitagliptin (Januvia)	Saxagliptin (Onglyza)
IC50 (nM)	3	18	50
Renal Clearance (L/h)	13.0	21.0	13.8
Volume Distribution (L)	71	198	151
Dosage (mg)	100	100	5
Metabolism	Hydrolysis	Hepatic (CYP3A4 & CYP2C8)	Hepatic (CYP3A4)

For Pharmacokinetic Data References, see: References