Dipeptidyl Peptidase-4 Inhibitor Pharmacokinetics

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Current revision

DPP4 Inhibitor Pharmacokinetics
Parameter	Vildagliptin (Galvus)	Sitagliptin (Januvia)	Saxagliptin (Onglyza)
T_max (hr)	1.75	1-4	2
C_max (ng/ml)	290	330	34
Bioavailability (%)	85	87	67
Protein Binding (%)	9	38	0
T_1/2 (hr)	2-3	12.4	2.5
AUC (ng/ml/hr)	1610	3470	101
IC₅₀ (nM)	3	18	50
Renal Clearance (L/h)	13.0	21.0	13.8
Volume Distribution (L)	71	198	151
Dosage (mg)	100	100	5
Metabolism	Hydrolysis	Hepatic (CYP3A4 & CYP2C8)	Hepatic (CYP3A4)

For Pharmacokinetic Data References, see: References

@@ Line 14: / Line 14: @@
 |-
 ! [[Pharmacokinetics#Cmax|C<sub>max</sub>]] (ng/ml)
-! [[Vildagliptin]]<br/>(Galvus)
+! 290
-! [[Sitagliptin]]<br/>(Januvia)
+! 330
-! [[Saxagliptin]]<br/>(Onglyza)
+! 34
 |-
 ! [[Pharmacokinetics#Bioavailability_.28F.29|Bioavailability]] (%)
 ! 85
 ! 87
-! [67
+! 67
 |-
 ! [[Pharmacokinetics#Protein_Binding|Protein Binding]] (%)
@@ Line 34: / Line 34: @@
 |-
 ! [[Pharmacokinetics#Area_Under_the_Curve_.28AUC.29|AUC]] (ng/ml/hr)
-! [[Vildagliptin]]<br/>(Galvus)
+! 1610
-! [[Sitagliptin]]<br/>(Januvia)
+! 3470
-! [[Saxagliptin]]<br/>(Onglyza)
+! 101
 |-
 ! [[Pharmacokinetics#Inhibitory_Concentration_.28IC50.29|IC<sub>50</sub>]] (nM)
 ! 3
 ! 18
-! [[Saxagliptin]]<br/>(Onglyza)
+! 50
 |-
 ! [[Pharmacokinetics#Clearance_.28Cl.29|Renal Clearance]] (L/h)
@@ Line 47: / Line 47: @@
 ! 21.0
 ! 13.8
+|-
+! [[Pharmacokinetics#Volume_of_Distribution_.28Vd.29|Volume Distribution]] (L)
+! 71
+! 198
+! 151
 |-
 ! Dosage (mg)
@@ Line 54: / Line 59: @@
 |-
 ! Metabolism
-! [[Vildagliptin]]<br/>(Galvus)
+! Hydrolysis
-! [[Sitagliptin]]<br/>(Januvia)
+! Hepatic (CYP3A4 & CYP2C8)
-! [[Saxagliptin]]<br/>(Onglyza)
+! Hepatic (CYP3A4)
 |}
 For Pharmacokinetic Data References, see: [[Treatments:Dipeptidyl Peptidase-4 Inhibitor Pharmacokinetics|References]]