Transthyretin

From Proteopedia

Revision as of 22:41, 23 September 2011

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Transthyretin (TTR) is a serum carrier ot the thyroid hormone thyroxine (T4) and retinol through its association with retinol-binding protein (RBP). Many small molecules bind to TTR T4-binding site. TTR is known to be associated with amyloid diseases.

3D structures of transthyretin

2pab, 1tta, 1ttb, 1etb, 1bmz, 1f41, 1dvq, 1fh2, 1qwh, 2h4e, 2qgb, 3cbr, 3d7p, 3cfm, 3i9p, 3a4d, 3a4e, 3a4f – hTTR – human

1eta, 1ttc, 1tsh, 2trh, 2try, 1bzd, 1bze, 1fhn, 1g10, 1x7s, 2qel, 3dgd, 3did, 3kgs – hTTR (amyloidogenic mutant)

1ttr – hTTR (cardiomyapatic mutant)

1bz8, 5ttr, 1f86, 1gko, 1iii, 1iik, 1ijn, 1sok, 1soq, 1x7t, 2g3x, 2g3z, 2g4e, 2g4g, 2noy, 3bt0, 3cxf, 3djr, 3djs, 3djt, 3djz, 3dk0, 3dk2, 3do4, 3gps, 3grb, 3grg, 3i9a, 3i9i – hTTR (mutant)

1tfp – TTR – chicken

2qpf – TTR - mouse

1oo2, 1sn2 – gsTTR – gilthead seabream

1gke – rTTR – rat

TTR binary complexes

1thc, 2h1x, 2h6u – hTTR + hydroxyaurone derivative

1tlm – hTTR + milrinone

1bm7 – hTTR + flufenamic acid

1dvs, 1dvt, 1dvu, 1dvx, 1dvy, 1dvz, 1tt6, 1tz8, 2f8i, [[2fbr, [[2flm, 2g5u, 2g9k, 2gab, 2qgc, 2qgd, 2qge, 3cn0, 3cn1, 3cn2, 3cn3, 3cn4, 3esn, 3eso, 3esp, 3glz, 3gs0, 3gs4, 3gs7, 3imr, 3ims, [[3imt, [[3imu, 3imv, 3imw, 3ipb, 3ipe, 3m10 – hTTR + amyloid disease inhibitor

1u21, 3cfn, 3cfq, 3cft, 3hj0, 3nee, 3neo, 3p3r, 3p3s, [[3p3t, [[3p3u – hTTR + inhibitor

1e3f, 1e4h, 1e5a, 2b15 – hTTR + phenol derivative

2b14, 2b16 – hTTR (mutant) + phenol derivative

3kgt, 3kgu – hTTR (mutant) + genistein

3ng5 – hTTR (mutant) + epigallocatechin gallate

3nes, 3nex – hTTR (mutant) + inhibitor

1tyr – hTTR + retinoic acid

1kgi – rTTR + tetraiodotyroacetic acid

1z7t - hTTR + tetraiodotyroacetic acid

1kgj – rTTR + dibromoflavone

1zcr, 1zd6 – hTTR + anion

1y1d, 2b77, 2b9a, 3d2t, 3fc8, 3fcb – hTTR + diflunisal derivative 3b56 – hTTR + salicylic acid derivative

TTR complexes with retinol-binding potein

1rlb, 1qab – hTTR + RBP

2wqa – hTTR + RBP + oleic acid

3bsz – hTTR + RBP + antibody

TTR complexes with thyroxine

2rox, 1ict – hTTR + T4

3ozk – hTTR (mutant) + T4

1tha, 2roy – hTTR + T4 derivative

1ie4 – rTTR + T4

1sn0 – gsTTR + T4

1sn5 – gsTTR + T4 derivative