Guanylate kinase
From Proteopedia
| Line 47: | Line 47: | ||
[[2ysd]], [[2yse]] - hMAGUK WW domain – NMR<BR /> | [[2ysd]], [[2yse]] - hMAGUK WW domain – NMR<BR /> | ||
[[2zaj]] - hMAGUK WW 2 domain – NMR<BR /> | [[2zaj]] - hMAGUK WW 2 domain – NMR<BR /> | ||
| + | |||
| + | [[Category:Topic Page]] | ||
Revision as of 11:29, 28 March 2012
Guanylate kinase (GK) catalyzes the transfer of phosphate from GMP to GDP using ATP as a phosphate source. GK is essential for recycling GMP and cGMP. GK also forms a domain in the membrane-associated GK (MAGUK) which functions in mitotic spindle orientation and cell adhesion. There is a single mutation in GK which converts it to a GK domain. The GK domain has no catalytic activity. The MAGUK contain PDZ, WW, SH3 and GK domains.
3D structures of guanylate kinase
1ex6 – yGK – yeast
3sqk – yGK (mutant)
1s4q, 1znw – MtGK – Mycobacterium tuberculosis
1z8f – MtGK (mutant)
1s96, 2anc – EcGK – Escherichia coli
1z6g – GK – Plasmodium falciparum
Guanylate kinase binary complex
1gky, 1ex7 – yGK + GMP
1lvg – GK + ADP + GMP – mouse
2an9 – EcGK + guanosine + GDP
2anb – EcGK + GMP
2f3t – EcGK + GMP derivative
2f3r – EcGK + adenosyl-guanosyl pentaphosphate
1znx – MtGK + GMP
1zny, 1znz – MtGK + GDP
2j41 – GK + GMP – Staphylococcus aureus
2qor - GK + GMP – Plasmodium vivax
3lnc - GK + GMP – Anaplasma phagocytophilum
3tr0 – GK residues 1-202 + GMP – Coxiella burnetii
Membrane-associated guanylate kinase
1uep – hMAGUK PDZ domain 3 – human – NMR
1ueq, 2kpk - hMAGUK PDZ domain 1 – NMR
1ujv - hMAGUK PDZ domain 2 – NMR
3bpu - hMAGUK PDZ domain 3 (mutant)
3soe - hMAGUK PDZ domain 3
2q9v - hMAGUK PDZ domain 4
1uew - hMAGUK PDZ domain 4 – NMR
1wfv - hMAGUK PDZ domain 5 – NMR
2r4h - hMAGUK PDZ domain 6 (mutant)
2i04 - hMAGUK PDZ domain 1 + papillomavirus peptide
2kpl - hMAGUK PDZ domain 1 + protein E6 peptide]] - NMR
2ysd, 2yse - hMAGUK WW domain – NMR
2zaj - hMAGUK WW 2 domain – NMR
