Transthyretin
From Proteopedia
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'''Transthyretin''' (TTR) is a serum carrier of the thyroid hormone thyroxine (T4) and retinol through its association with retinol-binding protein (RBP). Many small molecules bind to TTR T4-binding site. TTR is known to be associated with amyloid diseases. | '''Transthyretin''' (TTR) is a serum carrier of the thyroid hormone thyroxine (T4) and retinol through its association with retinol-binding protein (RBP). Many small molecules bind to TTR T4-binding site. TTR is known to be associated with amyloid diseases. | ||
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==3D structures of transthyretin== | ==3D structures of transthyretin== | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
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| + | ===Transthyretin=== | ||
[[2pab]], [[1tta]], [[1ttb]], [[1etb]], [[1bmz]], [[1f41]], [[1dvq]], [[1fh2]], [[1qwh]], [[2h4e]], [[2qgb]], [[3cbr]], [[3d7p]], [[3cfm]], [[3i9p]], [[3a4d]], [[3a4e]], [[3a4f]], [[3u2i]], [[3w3b]], [[4mrb]] – hTTR – human<br /> | [[2pab]], [[1tta]], [[1ttb]], [[1etb]], [[1bmz]], [[1f41]], [[1dvq]], [[1fh2]], [[1qwh]], [[2h4e]], [[2qgb]], [[3cbr]], [[3d7p]], [[3cfm]], [[3i9p]], [[3a4d]], [[3a4e]], [[3a4f]], [[3u2i]], [[3w3b]], [[4mrb]] – hTTR – human<br /> | ||
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[[1gke]] – rTTR – rat | [[1gke]] – rTTR – rat | ||
| - | + | ===TTR binary complexes=== | |
[[1thc]], [[2h1x]], [[2h6u]] – hTTR + hydroxyaurone derivative | [[1thc]], [[2h1x]], [[2h6u]] – hTTR + hydroxyaurone derivative | ||
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[[4hjs]], [[4hjt]], [[4hju]] – hTTR + covalent kinetic stabilizer<br /> | [[4hjs]], [[4hjt]], [[4hju]] – hTTR + covalent kinetic stabilizer<br /> | ||
| - | + | ===TTR complexes with retinol-binding protein=== | |
[[1rlb]], [[1qab]] – hTTR + RBP | [[1rlb]], [[1qab]] – hTTR + RBP | ||
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[[3bsz]] – hTTR + RBP + antibody | [[3bsz]] – hTTR + RBP + antibody | ||
| - | + | ===TTR complexes with thyroxine=== | |
[[2rox]], [[1ict]] – hTTR + T4 | [[2rox]], [[1ict]] – hTTR + T4 | ||
Revision as of 06:59, 21 August 2014
Template:STRUCTURE 1rlb
Transthyretin (TTR) is a serum carrier of the thyroid hormone thyroxine (T4) and retinol through its association with retinol-binding protein (RBP). Many small molecules bind to TTR T4-binding site. TTR is known to be associated with amyloid diseases.
Contents |
3D structures of transthyretin
Updated on 21-August-2014
Transthyretin
2pab, 1tta, 1ttb, 1etb, 1bmz, 1f41, 1dvq, 1fh2, 1qwh, 2h4e, 2qgb, 3cbr, 3d7p, 3cfm, 3i9p, 3a4d, 3a4e, 3a4f, 3u2i, 3w3b, 4mrb – hTTR – human
3u2j – hTTR - neutron
1eta, 1ttc, 1tsh, 2trh, 2try, 1bzd, 1bze, 1fhn, 1g1o, 1x7s, 2qel, 3dgd, 3did, 3kgs, 3tfb – hTTR (amyloidogenic mutant)
1ttr – hTTR (cardiomyapatic mutant)
1bz8, 5ttr, 1f86, 1gko, 1iii, 1iik, 1ijn, 1sok, 1soq, 1x7t, 2g3x, 2g3z, 2g4e, 2g4g, 2noy, 3bt0, 3cxf, 3djr, 3djs, 3djt, 3djz, 3dk0, 3dk2, 3do4, 3gps, 3grb, 3grg, 3i9a, 3i9i, 4mrc – hTTR (mutant)
1tfp – TTR – chicken
2qpf – TTR - mouse
1oo2, 1sn2 – gsTTR – gilthead seabream
1gke – rTTR – rat
TTR binary complexes
1thc, 2h1x, 2h6u – hTTR + hydroxyaurone derivative
1tlm – hTTR + milrinone
1bm7, 3ozl – hTTR + flufenamic acid
1dvs, 1dvt, 1dvu, 1dvx, 1dvy, 1dvz, 1tt6, 1tz8, 2f8i, 2fbr, 2flm, 2g5u, 2g9k, 2gab, 2qgc, 2qgd, 2qge, 3cn0, 3cn1, 3cn2, 3cn3, 3cn4, 3esn, 3eso, 3esp, 3glz, 3gs0, 3gs4, 3gs7, 3imr, 3ims, 3imt, 3imu, 3imv, 3imw, 3ipb, 3ipe, 3m10, 2fbr, 2flm, 3m1o, 3tct, 4fi7, 4fi8, 4fi6 – hTTR + amyloid disease inhibitor
4his, 4hiq - hTTR (mutant) + amyloid disease inhibitor
4abq, 4abv, 4abw, 4ac2, 4ac4, 4act, 4ank, 4abu – hTTR + ligand
4des, 4det, 4der, 4dew, 4deu – hTTR + flavonoid
1u21, 3cfn, 3cfq, 3cft, 3hj0, 3nee, 3neo, 3p3r, 3p3s, 3p3t, 3p3u, 4ky2, 4mas – hTTR + inhibitor
1e3f, 1e4h, 1e5a, 2b15 – hTTR + phenol derivative
4l1s - hTTR + benzamide derivative
4l1t - hTTR + benzoate derivative
4n85, 4n86 - hTTR + glabridin
4n87 - hTTR (mutant) + glabridin
2b14, 2b16 – hTTR (mutant) + phenol derivative
3kgt, 3kgu – hTTR (mutant) + genistein
3ng5 – hTTR (mutant) + epigallocatechin gallate
3nes, 3nex – hTTR (mutant) + inhibitor
1tyr – hTTR + retinoic acid
1kgi – rTTR + tetraiodotyroacetic acid
1z7j - hTTR + tetraiodotyroacetic acid
1kgj – rTTR + dibromoflavone
1zcr, 1zd6 – hTTR + anion
3ssg – hTTR + Zn
1y1d, 2b77, 2b9a, 3d2t, 3fc8, 3fcb, 2f7i, 4ikl, 4ikk, 4ikl, 4iki, 4ik7, 4ik6, 4iiz, 4ikj – hTTR + anti-inflammatory drug
4i89 - hTTR (mutant) + anti-inflammatory drug
4i87, 4i85 - hTTR (mutant) + fibrillogenesis inhibitor
3b56 – hTTR + salicylic acid derivative
4hjs, 4hjt, 4hju – hTTR + covalent kinetic stabilizer
TTR complexes with retinol-binding protein
2wqa – hTTR + RBP + oleic acid
3bsz – hTTR + RBP + antibody
TTR complexes with thyroxine
3ozk – hTTR (mutant) + T4
1tha, 2roy – hTTR + T4 derivative
1ie4 – rTTR + T4
1sn0 – gsTTR + T4
1sn5 – gsTTR + T4 derivative
