tRNA-guanine transglycosylase (TGT) is involved in the post-transcriptional modification of tRNA. TGT is involved in the replacement of guanine-34 by queuine precursor (preQ1) in the anticodon of tRNA. In archaebacteria TGT (ATGT) catalyzes the introduction of archaeosin precursor (preQ0) into the D-loop of tRNA.
3D structures of tRNA-guanine transglycosylase
Updated on 21-August-2014
TGT
1pud, 1p0d – ZmTGT – Zymomonas mobilis
1wkd, 1wke, 1wkf, 1ozm, 2oko, 2z1v, 2nso, 3bl3, 3hfy, 4gd0, 4h6e, 3unt, 3uvi, 4dxx, 4dy1, 4htb, 4ipp, 4jbr – ZmTGT (mutant)
2ash – TGT – Thermotoga maritima
TGT complexes
1efz, 1pxg, 1ozq, 2z1x, 2nqz, 3bld, 4gcx, 4e2v – ZmTGT (mutant) + preQ1
3bll – ZmTGT (mutant) + preQ1 derivative
1p0e – ZmTGT + preQ1
1p0b, 2qii – ZmTGT + preQ0
2pwv – ZmTGT (mutant) + preQ0
3blo, 4hqv, 4hsh, 4hvx – ZmTGT (mutant) + queuine
1enu, 1f3e – ZmTGT + aminophthalhydrazide
1r5y, 1q4w, 1q63, 1q65, 1q66, 1s38, 1s39, 1y5v, 1y5w, 1y5x, 2bbf, 2qzr, 3c2n, 3c2y, 3c2z, 3eos, 3eou, 3gc4, 1k4g, 1k4h, 3gc5, 3ge7, 3gev – ZmTGT + quinazoline inhibitor
1n2v, 2z1w – ZmTGT + pyridazine derivative
1q2r, 1q2s – ZmTGT + RNA
2pot, 2pwu, 4h7z – ZmTGT (mutant) + guanine
2z7k, 3rr4, 3tll, 4fr6, 4fsa, 4fr1, 4fps, 4gi4, 4giy, 4gkt – ZmTGT + benzoguanine derivative
3v0y, 3s1g, 3sm0, 4gg9, 4gh1, 4gh3, 4ghr – ZmTGT + benzohypoxanthine derivative
ATGT
1iq8 – PhATGT – Pyrococcus horikoshii
1it7 – PhATGT + guanine
1it8 – PhATGT + preQ0
1j2b – PhATGT + tRNA-Val
