Aldose Reductase
From Proteopedia
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| + | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | + | *Aldose Reductase | |
| - | [[1abn]], [[1ads]], [[3q65]] - hAldR +NADP – human<br /> | + | **[[1abn]], [[1ads]], [[3q65]] - hAldR +NADP – human<br /> |
| - | [[2alr]] – hAldR <br /> | + | **[[2alr]] – hAldR <br /> |
| - | [[1xgd]] – hAldR (mutant)<br /> | + | **[[1xgd]] – hAldR (mutant)<br /> |
| - | [[3q67]] – hAldR (mutant)+NADP<br /> | + | **[[3q67]] – hAldR (mutant)+NADP<br /> |
| - | [[3afm]] – SsAldR A1-R – ''Sphingomonas sp.''<br /> | + | **[[3afm]] – SsAldR A1-R – ''Sphingomonas sp.''<br /> |
| - | [[3afn]] - SsAldR A1-R+NADP<br /> | + | **[[3afn]] - SsAldR A1-R+NADP<br /> |
| - | [[1dla]], [[1cwn]] – pAldR - pig<br /> | + | **[[1dla]], [[1cwn]] – pAldR - pig<br /> |
| - | [[1ah4]], [[3cv7]] - pAldR+NADP<br /> | + | **[[1ah4]], [[3cv7]] - pAldR+NADP<br /> |
| - | [[1hqt]] – pAldR (mutant) + NADP<br /> | + | **[[1hqt]] – pAldR (mutant) + NADP<br /> |
| - | [[3krb]] – AldR+NADP – ''Ghiardia lamblia''<br /> | + | **[[3krb]] – AldR+NADP – ''Ghiardia lamblia''<br /> |
| - | [[2bgq]] – bAldR - barley<br /> | + | **[[2bgq]] – bAldR - barley<br /> |
| - | [[2bgs]] - bAldR+NADP<br /> | + | **[[2bgs]] - bAldR+NADP<br /> |
| - | [[4gca]] – AldR – mouse<br /> | + | **[[4gca]] – AldR – mouse<br /> |
| - | [[4hbk]] – AldR – ''Schistosoma japonicum''<br /> | + | **[[4hbk]] – AldR – ''Schistosoma japonicum''<br /> |
| - | + | *Aldose Reductase+inhibitors | |
| - | [[3ghr]], [[3ghs]], [[3ght]], [[3ghu]], [[2r24]], [[2pzn]], [[3g5e]], [[2qxw]], [[2iki]], [[2i16]], [[2i17]], [[1t40]], [[1t41]], [[1us0]], [[1el3]], [[3t42]] - hAldR +NADP+IDD inhibitors<br /> | + | **[[3ghr]], [[3ghs]], [[3ght]], [[3ghu]], [[2r24]], [[2pzn]], [[3g5e]], [[2qxw]], [[2iki]], [[2i16]], [[2i17]], [[1t40]], [[1t41]], [[1us0]], [[1el3]], [[3t42]] - hAldR +NADP+IDD inhibitors<br /> |
| - | [[3onb]], [[3onc]] – hAldR (mutant) +NADP+IDD inhibitor<br /> | + | **[[3onb]], [[3onc]] – hAldR (mutant) +NADP+IDD inhibitor<br /> |
| - | [[3u2c]] - hAldR +NADP+ NSAID inhibitor<br /> | + | **[[3u2c]] - hAldR +NADP+ NSAID inhibitor<br /> |
| - | [[3bcj]], [[1x97]], [[1x98]], [[1pwm]], [[1ef3]], [[2pd5]], [[2dux]], [[2duz]], [[2dv0]], [[2fz8]], [[2fz9]], [[2hv5]], [[2hvn]], [[2hvo]], [[1mar]], [[2fzb]], [[2fzd]], [[1z3n]], [[1pwl]], [[1iei]], [[4jir]] - hAldR+NADP+inhibitor for diabetic treatment<br /> | + | **[[3bcj]], [[1x97]], [[1x98]], [[1pwm]], [[1ef3]], [[2pd5]], [[2dux]], [[2duz]], [[2dv0]], [[2fz8]], [[2fz9]], [[2hv5]], [[2hvn]], [[2hvo]], [[1mar]], [[2fzb]], [[2fzd]], [[1z3n]], [[1pwl]], [[1iei]], [[4jir]] - hAldR+NADP+inhibitor for diabetic treatment<br /> |
| - | [[1z89]], [[1z8a]] - hAldR+NADP+sulfonyl-pyridazinone<br /> | + | **[[1z89]], [[1z8a]] - hAldR+NADP+sulfonyl-pyridazinone<br /> |
| - | [[2pdg]], [[2pdh]] - hAldR+NADP+uracil inhibitor<br /> | + | **[[2pdg]], [[2pdh]] - hAldR+NADP+uracil inhibitor<br /> |
| - | [[2j8t]], [[1x96]], [[2acs]], [[2acu]] - hAldR+NADP+citrate<br /> | + | **[[2j8t]], [[1x96]], [[2acs]], [[2acu]] - hAldR+NADP+citrate<br /> |
| - | [[2acq]] - hAldR +NADP+glucose phosphate<br /> | + | **[[2acq]] - hAldR +NADP+glucose phosphate<br /> |
| - | [[2acr]] - hAldR +NADP+cacodylate<br /> | + | **[[2acr]] - hAldR +NADP+cacodylate<br /> |
| - | [[2ikg]], [[2ikh]], [[2ikj]], [[3v35]] - hAldR+NADP+nitro-substituted inhibitor<br /> | + | **[[2ikg]], [[2ikh]], [[2ikj]], [[3v35]] - hAldR+NADP+nitro-substituted inhibitor<br /> |
| - | [[3v36]] - hAldR+NADP+ glyceraldehyde + azine<br /> | + | **[[3v36]] - hAldR+NADP+ glyceraldehyde + azine<br /> |
| - | [[2nvc]], [[2nvd]] - hAldR+NADP+isothiazole inhibitor<br /> | + | **[[2nvc]], [[2nvd]] - hAldR+NADP+isothiazole inhibitor<br /> |
| - | [[3p2v]] - hAldR+NADP+ benzothiazepine inhibitor<br /> | + | **[[3p2v]] - hAldR+NADP+ benzothiazepine inhibitor<br /> |
| - | [[2pev]], [[2pf8]], [[2pfh]] - hAldR+NADP+IDD inhibitor+ fidarestat<br /> | + | **[[2pev]], [[2pf8]], [[2pfh]] - hAldR+NADP+IDD inhibitor+ fidarestat<br /> |
| - | [[2ipw]], [[2iq0]], [[2iqd]], [[2isf]], [[2ine]], [[2inz]], [[2is7]] - hAldR+NADP+ acid<br /> | + | **[[2ipw]], [[2iq0]], [[2iqd]], [[2isf]], [[2ine]], [[2inz]], [[2is7]] - hAldR+NADP+ acid<br /> |
| - | [[2f2k]] - hAldR+NADP+DEG<br /> | + | **[[2f2k]] - hAldR+NADP+DEG<br /> |
| - | [[2pdn]], [[2pdq]] – hAldR (mutant)+NADP+uracil inhibitor<br /> | + | **[[2pdn]], [[2pdq]] – hAldR (mutant)+NADP+uracil inhibitor<br /> |
| - | [[2pdb]], [[2pdf]], [[2pdi]], [[2pdm]], [[2pdx]], [[3len]], [[3m0i]], [[3mb9]], [[2pd9]], [[2pdw]], [[2pdy]], [[2agt]], [[2pdl]] – hAldR (mutant)+NADP+inhibitor for diabetic treatment<br /> | + | **[[2pdb]], [[2pdf]], [[2pdi]], [[2pdm]], [[2pdx]], [[3len]], [[3m0i]], [[3mb9]], [[2pd9]], [[2pdw]], [[2pdy]], [[2agt]], [[2pdl]] – hAldR (mutant)+NADP+inhibitor for diabetic treatment<br /> |
| - | [[2pdk]] - hAldR (mutant)+NADP+sorbinil<br /> | + | **[[2pdk]] - hAldR (mutant)+NADP+sorbinil<br /> |
| - | [[1az1]] – hAldR (mutant)+NADP+alrestatin<br /> | + | **[[1az1]] – hAldR (mutant)+NADP+alrestatin<br /> |
| - | [[1az2]] - hAldR (mutant)+NADP+citrate<br /> | + | **[[1az2]] - hAldR (mutant)+NADP+citrate<br /> |
| - | [[3lbo]], [[3ld5]], [[3lql]], [[3lz5]], [[2pdc]], [[3lep]], [[3lqg]], [[3lz3]], [[3m4h]], [[2pdj]], [[2pdp]], [[2pdu]], [[3m64]], [[3mc5]] - hAldR (mutant)+IDD inhibitors<br /> | + | **[[3lbo]], [[3ld5]], [[3lql]], [[3lz5]], [[2pdc]], [[3lep]], [[3lqg]], [[3lz3]], [[3m4h]], [[2pdj]], [[2pdp]], [[2pdu]], [[3m64]], [[3mc5]] - hAldR (mutant)+IDD inhibitors<br /> |
| - | [[3dn5]] – hAldR+NADP+biaryl inhibitor<br /> | + | **[[3dn5]] – hAldR+NADP+biaryl inhibitor<br /> |
| - | [[3v9q]] - hAldR+NADP+ phenol derivative<br /> | + | **[[3v9q]] - hAldR+NADP+ phenol derivative<br /> |
| - | [[3rx2]], [[3rx3]], [[3rx4]], [[3s3g]] - hAldR+NADP+ sulindac inhibitor<br /> | + | **[[3rx2]], [[3rx3]], [[3rx4]], [[3s3g]] - hAldR+NADP+ sulindac inhibitor<br /> |
| - | [[3fx4]] – pAldR+NADP+thiazolidine derivative <br /> | + | **[[3fx4]] – pAldR+NADP+thiazolidine derivative <br /> |
| - | [[3h4g]] – pAldR+NADP+fidarestat<br /> | + | **[[3h4g]] – pAldR+NADP+fidarestat<br /> |
| - | [[1ah3]], [[1ae4]] - pAldR+NADP+tolrestat<br /> | + | **[[1ah3]], [[1ae4]] - pAldR+NADP+tolrestat<br /> |
| - | [[1ah0]] - pAldR+NADP+sorbinil<br /> | + | **[[1ah0]] - pAldR+NADP+sorbinil<br /> |
| - | [[1eko]] - pAldR+NADP+IDD inhibitor<br /> | + | **[[1eko]] - pAldR+NADP+IDD inhibitor<br /> |
| - | [[2vdg]] – bAldR+NADP+butanol <br /> | + | **[[2vdg]] – bAldR+NADP+butanol <br /> |
| - | + | }} | |
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:48, 16 November 2014
Aldose Reductase (AldR) is an NADPH-dependent enzyme which reduces aldehydes and carbonyls. It reduces glucose to sorbitol in the glucose metabolism pathway. The AldR is implicated in diabetics and causing Iodine Deficiency Disorder (IDD) and its treatment involves the use of IDD inhibitors of AldR.
3D Structures of Aldose Reductase
Updated on 16-November-2014
