4trq

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'''Unreleased structure'''
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==Crystal structure of Sac3/Thp1/Sem1==
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<StructureSection load='4trq' size='340' side='right' caption='[[4trq]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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The entry 4trq is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4trq]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TRQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TRQ FirstGlance]. <br>
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Authors: Hellerschmied, D., Schneider, S., Kohler, A., Clausen, T.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4trq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4trq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4trq RCSB], [http://www.ebi.ac.uk/pdbsum/4trq PDBsum]</span></td></tr>
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Description: Crystal structure of Sac3/Thp1/Sem1
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</table>
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[[Category: Unreleased Structures]]
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== Function ==
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[[Category: Schneider, S]]
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[[http://www.uniprot.org/uniprot/SAC3_YEAST SAC3_YEAST]] Component of the SAC3-THP1 complex, which functions in transcription-coupled mRNA export from the nucleus to the cytoplasm. SAC3-THP1 functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket), by association with components of the nuclear mRNA export machinery (MEX67-MTR2 and SUB2) in the nucleoplasm and the nucleoporin NUP1 at the nuclear basket.<ref>PMID:12411502</ref> <ref>PMID:12702719</ref> [[http://www.uniprot.org/uniprot/SEM1_YEAST SEM1_YEAST]] Versatile protein that might stabilize multiple protein complexes involved in diverse pathways. Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis. Associates also with the TREX-2 complex that is required for transcription-coupled mRNA export, and the COP9 signalosome, which is involved in deneddylation.<ref>PMID:19289793</ref> <ref>PMID:15117943</ref> [[http://www.uniprot.org/uniprot/THP1_YEAST THP1_YEAST]] Component of the SAC3-THP1 complex, which functions in transcription-coupled mRNA export from the nucleus to the cytoplasm. SAC3-THP1 functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket), by association with components of the nuclear mRNA export machinery (MEX67-MTR2 and SUB2) in the nucleoplasm and the nucleoporin NUP1 at the nuclear basket. THP1 binds to RNA in vitro.<ref>PMID:11139493</ref> <ref>PMID:12411502</ref> <ref>PMID:12702719</ref>
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[[Category: Kohler, A]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Clausen, T]]
[[Category: Clausen, T]]
[[Category: Hellerschmied, D]]
[[Category: Hellerschmied, D]]
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[[Category: Kohler, A]]
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[[Category: Schneider, S]]
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[[Category: Gene expression]]
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[[Category: Gene regulation]]
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[[Category: Pci domain]]
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[[Category: Trex-2]]

Revision as of 13:33, 26 August 2015

Crystal structure of Sac3/Thp1/Sem1

4trq, resolution 3.10Å

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