Adenosine A2A receptor
From Proteopedia
(Difference between revisions)
| Line 11: | Line 11: | ||
== Relevance == | == Relevance == | ||
| - | A2AR is responsible for regulating myocardial blood flow. It is involved in cerebral and renal blood flow, immune function, pain regulation and sleep. For details see [[G protein-coupled receptor]]. | + | A2AR is responsible for regulating myocardial blood flow. It is involved in cerebral and renal blood flow, immune function, pain regulation and sleep. For details see [[G protein-coupled receptor]]. A2AR is blocked by caffeine producing the arousal effect.<ref>PMID:21734299</ref> See [[Caffeine]]. |
== Structural highlights == | == Structural highlights == | ||
| Line 27: | Line 27: | ||
[[2ydv]] – hA2AR (mutant) + agonist<br /> | [[2ydv]] – hA2AR (mutant) + agonist<br /> | ||
[[3pwh]], [[3rey]], [[3rfm]], [[3uza]], [[3uzc]] – hA2AR (mutant) + antagonist<br /> | [[3pwh]], [[3rey]], [[3rfm]], [[3uza]], [[3uzc]] – hA2AR (mutant) + antagonist<br /> | ||
| + | [[3rfm]] – hA2AR (mutant) + caffeine<br /> | ||
[[3vg9]], [[3vga]] – hA2AR (mutant) + antibody<br /> | [[3vg9]], [[3vga]] – hA2AR (mutant) + antibody<br /> | ||
[[4eiy]] – hA2AR/cytochrome b562 + antagonist <br /> | [[4eiy]] – hA2AR/cytochrome b562 + antagonist <br /> | ||
Revision as of 15:39, 5 January 2016
| |||||||||||
3D Structures of adenosine A2A receptor
Updated on 05-January-2016
3eml – hA2AR/lysozyme + antagonist – human
3qak – hA2AR/lysozyme + agonist
2ydo – hA2AR (mutant) + adenosine
2ydv – hA2AR (mutant) + agonist
3pwh, 3rey, 3rfm, 3uza, 3uzc – hA2AR (mutant) + antagonist
3rfm – hA2AR (mutant) + caffeine
3vg9, 3vga – hA2AR (mutant) + antibody
4eiy – hA2AR/cytochrome b562 + antagonist
References
- ↑ Lebon G, Warne T, Edwards PC, Bennett K, Langmead CJ, Leslie AG, Tate CG. Agonist-bound adenosine A(2A) receptor structures reveal common features of GPCR activation. Nature. 2011 May 18. PMID:21593763 doi:10.1038/nature10136
- ↑ Lazarus M, Shen HY, Cherasse Y, Qu WM, Huang ZL, Bass CE, Winsky-Sommerer R, Semba K, Fredholm BB, Boison D, Hayaishi O, Urade Y, Chen JF. Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens. J Neurosci. 2011 Jul 6;31(27):10067-75. doi: 10.1523/JNEUROSCI.6730-10.2011. PMID:21734299 doi:http://dx.doi.org/10.1523/JNEUROSCI.6730-10.2011
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Nina Clavio, Joel L. Sussman
