Thioredoxin Reductase
From Proteopedia
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{{STRUCTURE_2a87| PDB=2a87 | SIZE=400| SCENE= |right|CAPTION=Thioredoxin reductase dimer complex with FAD, NADP and Mg+2 (green) ion, [[2a87]] }} | {{STRUCTURE_2a87| PDB=2a87 | SIZE=400| SCENE= |right|CAPTION=Thioredoxin reductase dimer complex with FAD, NADP and Mg+2 (green) ion, [[2a87]] }} | ||
| + | == Function == | ||
| + | [[Thioredoxin Reductase]] (TrxR) is an enzyme which reduces thioredoxin using NADPH<ref>PMID:11012661</ref>. '''TrxR-2''' is mitochondrial. For more details see [[User:Sarah Abdalla/Thioredoxin Reductase]]. | ||
| - | + | == Disease == | |
| + | Mutations in TrxR-2 are associated with familial glucocorticoid deficiency<ref>PMID:24601690</ref>. | ||
== 3D Structures of Thioredoxin Reductase == | == 3D Structures of Thioredoxin Reductase == | ||
Revision as of 10:18, 13 September 2016
Contents |
Function
Thioredoxin Reductase (TrxR) is an enzyme which reduces thioredoxin using NADPH[1]. TrxR-2 is mitochondrial. For more details see User:Sarah Abdalla/Thioredoxin Reductase.
Disease
Mutations in TrxR-2 are associated with familial glucocorticoid deficiency[2].
3D Structures of Thioredoxin Reductase
Updated on 13-September-2016
References
- ↑ Arner ES, Holmgren A. Physiological functions of thioredoxin and thioredoxin reductase. Eur J Biochem. 2000 Oct;267(20):6102-9. PMID:11012661
- ↑ Prasad R, Chan LF, Hughes CR, Kaski JP, Kowalczyk JC, Savage MO, Peters CJ, Nathwani N, Clark AJ, Storr HL, Metherell LA. Thioredoxin Reductase 2 (TXNRD2) mutation associated with familial glucocorticoid deficiency (FGD). J Clin Endocrinol Metab. 2014 Aug;99(8):E1556-63. doi: 10.1210/jc.2013-3844. Epub, 2014 Mar 6. PMID:24601690 doi:http://dx.doi.org/10.1210/jc.2013-3844
