Thioredoxin Reductase

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{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
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*Thioredoxin reductase
+
*Thioredoxin reductase apo
 +
 
 +
**[[4ccr]] - EhTrxR - ''Entamoeba histolytica''<br />
 +
**[[5utx]] – VvTrxR – ''Vibrio vulnificus''<br />
 +
**[[5c04]], [[5id2]], [[4x0x]], [[4x1u]] – MtTrxR - ''Mycobacterium tuberculosis''<br />
 +
**[[3r9u]] – TrxR – ''Campylobacter jejuni''<br />
 +
**[[4zn0]] – TrxR – ''Methanosarcina mazei''<br />
 +
**[[4xrd]], [[4xs1]], [[4xs4]], [[4xs6]], [[4xs8]], [[4xts]], [[4xra]] – TrxR (mutant) – ''Salmonella enterica''<br />
 +
 
 +
*Thioredoxin reductase complex with FAD
**[[1cl0]], [[1tde]], [[1trb]], [[4o5q]], [[4o5u]] – EcTrxR+FAD – ''Eschericia coli''<br />
**[[1cl0]], [[1tde]], [[1trb]], [[4o5q]], [[4o5u]] – EcTrxR+FAD – ''Eschericia coli''<br />
-
**[[1tdf]] - EcTrxR+FAD+NADPH<br />
 
-
**[[1f6m]] - EcTrxR (mutant)+Trx-1+FAD+AADPH<br />
 
-
**[[1h6v]] – rTrxR (mutant)+FAD+NADPH – rat<br />
 
**[[1vdc]] – TrxR+FAD – ''Arabidopsis thaliana''<br />
**[[1vdc]] – TrxR+FAD – ''Arabidopsis thaliana''<br />
-
**[[2a87]] - MtTrxR+FAD+NADPH – ''Mycobacterium tuberculosis''<br />
 
-
**[[5c04]], [[5id2]], [[4x0x]], [[4x1u]] – MtTrxR <br />
 
**[[3cty]] - TrxR+FAD – ''Thermoplasma acidophilum''<br />
**[[3cty]] - TrxR+FAD – ''Thermoplasma acidophilum''<br />
**[[2zbw]] – TrxR + FAD – ''Thermus thermophilus''<br />
**[[2zbw]] – TrxR + FAD – ''Thermus thermophilus''<br />
**[[5j60]] – TrxR + FAD – ''Gloeobacter violaceus''<br />
**[[5j60]] – TrxR + FAD – ''Gloeobacter violaceus''<br />
 +
**[[3ish]] - HpTrxR+FAD - ''Helicobacter pylori''<br />
 +
**[[2q7v]] - TrxR+FAD – ''Deinococcus radiodurans''<br />
 +
**[[4b1b]] - PfTrxR+FAD – ''Plasmodium falciparum''<br />
 +
**[[4jnq]] – TrxR + FDA – ''Brucella melitensis''<br />
 +
**[[4ntd]] – TrxR + FDA + glutathione – ''Steptomyces clavuligerus''<br />
 +
**[[5m5j]] – TrxR + FAD – ''Giardia duodenalis''<br />
 +
**[[5uth]] – TrxR + FAD – ''Mycobacterium smegmatis''<br />
 +
**[[5uwy]] – TrxR + FAD – ''Streptococcus pyogenes''<br />
 +
 +
*Thioredoxin reductase complex with FAD and NADP
 +
 +
**[[1tdf]] - EcTrxR+FAD+NADPH<br />
 +
**[[1f6m]] - EcTrxR (mutant)+Trx-1+FAD+AADPH<br />
 +
**[[1h6v]] – rTrxR (mutant)+FAD+NADPH – rat<br />
 +
**[[2a87]] - MtTrxR+FAD+NADPH <br />
**[[3d8x]] - yTrxR+FAD+NADPH - yeast<br />
**[[3d8x]] - yTrxR+FAD+NADPH - yeast<br />
**[[2nvk]] - DmTrxR+FAD+NADPH – ''Drosophila melanogaster''<br />
**[[2nvk]] - DmTrxR+FAD+NADPH – ''Drosophila melanogaster''<br />
-
**[[2q0k]], [[2q0l]] - HpTrxR+FAD+NADPH – ''Helicobacter pylori''<br />
+
**[[2q0k]], [[2q0l]] - HpTrxR+FAD+NADPH <br />
-
**[[3ish]] - HpTrxR+FAD<br />
+
**[[4a5l]], [[4up3]], [[4cbq]] - EhTrxR+FAD+NADPH <br />
-
**[[2q7v]] - TrxR+FAD – ''Deinococcus radiodurans''<br />
+
-
**[[3r9u]] – TrxR – ''Campylobacter jejuni''<br />
+
-
**[[4a5l]], [[4up3]], [[4cbq]] - EhTrxR+FAD+NADPH – ''Entamoeba histolytica''<br />
+
**[[4a65]] - EhTrxR+FAD+NADPH + Au<br />
**[[4a65]] - EhTrxR+FAD+NADPH + Au<br />
**[[4ccq]] - EhTrxR+NADPH<br />
**[[4ccq]] - EhTrxR+NADPH<br />
-
**[[4ccr]] - EhTrxR<br />
 
-
**[[4b1b]] - PfTrxR+FAD – ''Plasmodium falciparum''<br />
 
**[[4gcm]] - TrxR+FAD+NADPH – ''Staphylococcus aureus''<br />
**[[4gcm]] - TrxR+FAD+NADPH – ''Staphylococcus aureus''<br />
-
**[[4jnq]] – TrxR + FDA – ''Brucella melitensis''<br />
+
**[[5mh4]], [[5mjk]], [[5mip]], [[5miq]], [[5mir]], [[5mis]], [[5mit]] – TrxR + FAD + NAPD – ''Lactococcus lactis''<br />
-
**[[4ntd]] – TrxR + FDA + glutathione – ''Steptomyces clavuligerus''<br />
+
**[[5usx]], [[5vt3]] – VvTrxR + FAD + NAPD <br />
-
**[[4zn0]] – TrxR – ''Methanosarcina mazei''<br />
+
-
**[[4xrd]], [[4xs1]], [[4xs4]], [[4xs6]], [[4xs8]], [[4xts]], [[4xra]] – TrxR (mutant) – ''Salmonella enterica''<br />
+
*Thioredoxin reductase 1
*Thioredoxin reductase 1

Revision as of 17:54, 10 October 2017

Human Thioredoxin reductase dimer (cyan, green) complex with thioredoxin (yellow, pink), glycerol and FAD (PDB entry 3qfa)

Drag the structure with the mouse to rotate

3D Structures of Thioredoxin Reductase

Updated on 10-October-2017

References

  1. ↑ Arner ES, Holmgren A. Physiological functions of thioredoxin and thioredoxin reductase. Eur J Biochem. 2000 Oct;267(20):6102-9. PMID:11012661
  2. ↑ Prasad R, Chan LF, Hughes CR, Kaski JP, Kowalczyk JC, Savage MO, Peters CJ, Nathwani N, Clark AJ, Storr HL, Metherell LA. Thioredoxin Reductase 2 (TXNRD2) mutation associated with familial glucocorticoid deficiency (FGD). J Clin Endocrinol Metab. 2014 Aug;99(8):E1556-63. doi: 10.1210/jc.2013-3844. Epub, 2014 Mar 6. PMID:24601690 doi:http://dx.doi.org/10.1210/jc.2013-3844
  3. ↑ Fritz-Wolf K, Kehr S, Stumpf M, Rahlfs S, Becker K. Crystal structure of the human thioredoxin reductase-thioredoxin complex. Nat Commun. 2011 Jul 12;2:383. doi: 10.1038/ncomms1382. PMID:21750537 doi:10.1038/ncomms1382

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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