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| - | [[Image:2bgq.png|left|200px|thumb|Crystal structure of Aldose Reductase [[2bgq]]]]
| + | <StructureSection load='1ads' size='400' side='right' caption='Human aldose reductase complex with cofactor NADP (PDB code [[1ads]])' scene='43/436098/Cv/2'> |
| - | {{STRUCTURE_2bgq| PDB=2bgq | SIZE=400| SCENE=Aldose_Reductase/Cv/1 |right|CAPTION=Barley aldose reductase complex with sulfate [[2bgq]] }}
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| - | [[Aldose Reductase]] (AldR) is an NADPH-dependent enzyme which reduces aldehydes and carbonyls. It reduces glucose to sorbitol in the glucose metabolism pathway. The AldR is implicated in diabetics and causing Iodine Deficiency Disorder (IDD) and its treatment involves the use of IDD inhibitors of AldR. The images at the left and at the right correspond to one representative AldR, ''i.e.'' the crystal structure of barley apo-Aldose Reductase ([[2bgq]]).
| + | == Function == |
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| | + | [[Aldose Reductase]] (AldR) is an NADPH-dependent enzyme which reduces aldehydes and carbonyls. It reduces glucose to sorbitol in the glucose metabolism pathway.<ref>PMID:1734286</ref> |
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| | + | == Disease == |
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| + | The AldR is implicated in diabetics and causing Iodine Deficiency Disorder (IDD) and its treatment involves the use of IDD inhibitors of AldR. |
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| - | == 3D Structures of Aldose Reductase == | + | == Structural highlights == |
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| - | ''Update January 2013'' | + | AldR structure is of a <scene name='43/436098/Cv/3'>β/α-barrel</scene>. The <scene name='43/436098/Cv/8'>active site is located in the barrel core</scene>.<ref>PMID:1621098</ref> |
| | + | *<scene name='43/436098/Cv/7'>Active site interactions</scene>. Water molecules are shown as red spheres. |
| | + | *<scene name='43/436098/Cv/9'>Active site tunnel</scene>. |
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| - | ===Aldose Reductase=== | + | == 3D Structures of aldose reductase == |
| | + | [[Aldose reductase 3D structures]] |
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| - | [[1abn]], [[1ads]], [[3q65]] - hAldR +NADP – human<br />
| + | </StructureSection> |
| - | [[1xgd]] – hAldR (mutant)<br />
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| - | [[3q67]] – hAldR (mutant)+NADP<br />
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| - | [[3afm]] – SsAldR A1-R – ''Sphingomonas sp.''<br />
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| - | [[3afn]] - SsAldR A1-R+NADP<br />
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| - | [[1dla]] – pAldR - pig<br />
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| - | [[1ah4]] - pAldR+NADP<br />
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| - | [[3krb]] – AldR+NADP – ''Ghiardia lamblia''<br />
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| - | [[2bgq]] – bAldR - barley<br />
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| - | [[2bgs]] - bAldR+NADP<br />
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| - | ===Aldose Reductase+inhibitors=== | + | == References == |
| - | | + | <references/> |
| - | [[3ghr]], [[3ghs]], [[3ght]], [[3ghu]], [[2r24]], [[2pzn]], [[3g5e]], [[2qxw]], [[2iki]], [[2i16]], [[2i17]], [[1t40]], [[1t41]], [[1us0]], [[1el3]], [[3t42]] - hAldR +NADP+IDD inhibitors<br />
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| - | [[3onb]], [[3onc]] – hAldR (mutant) +NADP+IDD inhibitor<br />
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| - | [[3u2c]] - hAldR +NADP+ NSAID inhibitor<br />
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| - | [[3bcj]], [[1x97]], [[1x98]], [[1pwm]], [[1ef3]] - hAldR+NADP+fidarestat<br />
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| - | [[2pd5]], [[2dux]], [[2duz]], [[2dv0]], [[2fz8]], [[2fz9]], [[2hv5]], [[2hvn]], [[2hvo]], [[1mar]] - hAldR+NADP+zopolrestat<br />
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| - | [[2fzb]], [[2fzd]] - hAldR+NADP+tolrestat<br />
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| - | [[1z3n]] - hAldR+NADP+lidorestat<br />
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| - | [[1pwl]] - hAldR+NADP+minalrestat<br />
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| - | [[1iei]] - hAldR+NADP+zenarestat<br />
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| - | [[1z89]], [[1z8a]] - hAldR+NADP+sulfonyl-pyridazinone<br />
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| - | [[2pdg]], [[2pdh]] - hAldR+NADP+uracil inhibitor<br />
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| - | [[2j8t]], [[1x96]], [[2acs]], [[2acu]] - hAldR+NADP+citrate<br />
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| - | [[2acq]] - hAldR +NADP+glucose phosphate<br />
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| - | [[2acr]] - hAldR +NADP+cacodylate<br />
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| - | [[2ikg]], [[2ikh]], [[2ikj]], [[3v35]] - hAldR+NADP+nitro-substituted inhibitor<br />
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| - | [[3v36]] - hAldR+NADP+ glyceraldehyde + azine<br />
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| - | [[2nvc]], [[2nvd]] - hAldR+NADP+isothiazole inhibitor<br />
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| - | [[3p2v]] - hAldR+NADP+ benzothiazepine inhibitor<br />
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| - | [[2pev]], [[2pf8]], [[2pfh]] - hAldR+NADP+IDD inhibitor+ fidarestat<br />
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| - | [[2ipw]], [[2iq0]], [[2iqd]], [[2isf]], [[2ine]], [[2inz]], [[2is7]] - hAldR+NADP+ acid<br />
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| - | [[2f2k]] - hAldR+NADP+DEG<br />
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| - | [[2pdn]], [[2pdq]] – hAldR (mutant)+NADP+uracil inhibitor<br />
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| - | [[2pdb]], [[2pdf]], [[2pdi]], [[2pdm]], [[2pdx]], [[3len]], [[3m0i]], [[3mb9]] – hAldR (mutant)+NADP+zopolrestat<br />
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| - | [[2pd9]], [[2pdw]], [[2pdy]], [[2agt]] – hAldR (mutant)+NADP+fidarestat<br />
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| - | [[2pdk]] - hAldR (mutant)+NADP+sorbinil<br />
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| - | [[2pdl]] - hAldR (mutant)+NADP+tolrestat<br />
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| - | [[1az1]] – hAldR (mutant)+NADP+alrestatin<br />
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| - | [[1az2]] - hAldR (mutant)+NADP+citrate<br />
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| - | [[3lbo]], [[3ld5]], [[3lql]], [[3lz5]], [[2pdc]], [[3lep]], [[3lqg]], [[3lz3]], [[3m4h]], [[2pdj]], [[2pdp]], [[2pdu]], [[3m64]], [[3mc5]] - hAldR (mutant)+IDD inhibitors<br />
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| - | [[3dn5]] – hAldR+NADP+biaryl inhibitor<br />
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| - | [[3rx2]], [[3rx3]], [[3rx4]], [[3s3g]] - hAldR+NADP+ sulindac inhibitor<br />
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| - | [[3fx4]] – pAldR+NADP+thiazolidine derivative <br />
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| - | [[3h4g]] – pAldR+NADP+fidarestat<br />
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| - | [[1ah3]] - pAldR+NADP+tolrestat<br />
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| - | [[1ah0]] - pAldR+NADP+sorbinil<br />
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| - | [[1eko]] - pAldR+NADP+IDD inhibitor<br />
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| - | [[2vdg]] – bAldR+NADP+butanol <br />
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