Aldose Reductase

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{{STRUCTURE_2bgq| PDB=2bgq | SIZE=400| SCENE=Aldose_Reductase/Cv/1 |right|CAPTION=Barley aldose reductase complex with sulfate [[2bgq]] }}
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<StructureSection load='1ads' size='400' side='right' caption='Human aldose reductase complex with cofactor NADP (PDB code [[1ads]])' scene='43/436098/Cv/2'>
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[[Aldose Reductase]] (AldR) is an NADPH-dependent enzyme which reduces aldehydes and carbonyls. It reduces glucose to sorbitol in the glucose metabolism pathway. The AldR is implicated in diabetics and causing Iodine Deficiency Disorder (IDD) and its treatment involves the use of IDD inhibitors of AldR.
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== Function ==
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[[Aldose Reductase]] (AldR) is an NADPH-dependent enzyme which reduces aldehydes and carbonyls. It reduces glucose to sorbitol in the glucose metabolism pathway.<ref>PMID:1734286</ref>
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== 3D Structures of Aldose Reductase ==
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== Disease ==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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The AldR is implicated in diabetics and causing Iodine Deficiency Disorder (IDD) and its treatment involves the use of IDD inhibitors of AldR.
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Aldose Reductase
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== Structural highlights ==
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**[[1abn]], [[1ads]], [[3q65]] - hAldR +NADP – human<br />
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AldR structure is of a <scene name='43/436098/Cv/3'>β/α-barrel</scene>. The <scene name='43/436098/Cv/8'>active site is located in the barrel core</scene>.<ref>PMID:1621098</ref>
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**[[2alr]] – hAldR <br />
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*<scene name='43/436098/Cv/7'>Active site interactions</scene>. Water molecules are shown as red spheres.
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**[[1xgd]] – hAldR (mutant)<br />
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*<scene name='43/436098/Cv/9'>Active site tunnel</scene>.
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**[[3q67]] – hAldR (mutant)+NADP<br />
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**[[3afm]] – SsAldR A1-R – ''Sphingomonas sp.''<br />
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**[[3afn]] - SsAldR A1-R+NADP<br />
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**[[1dla]], [[1cwn]] – pAldR - pig<br />
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**[[1ah4]], [[3cv7]] - pAldR+NADP<br />
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**[[1hqt]] – pAldR (mutant) + NADP<br />
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**[[3krb]] – AldR+NADP – ''Ghiardia lamblia''<br />
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**[[2bgq]] – bAldR - barley<br />
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**[[2bgs]] - bAldR+NADP<br />
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**[[4gca]] – AldR – mouse<br />
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**[[4hbk]] – AldR – ''Schistosoma japonicum''<br />
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*Aldose Reductase+inhibitors
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== 3D Structures of aldose reductase ==
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[[Aldose reductase 3D structures]]
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**[[3ghr]], [[3ghs]], [[3ght]], [[3ghu]], [[2r24]], [[2pzn]], [[3g5e]], [[2qxw]], [[2iki]], [[2i16]], [[2i17]], [[1t40]], [[1t41]], [[1us0]], [[1el3]], [[3t42]] - hAldR +NADP+IDD inhibitors<br />
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</StructureSection>
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**[[3onb]], [[3onc]] – hAldR (mutant) +NADP+IDD inhibitor<br />
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**[[3u2c]] - hAldR +NADP+ NSAID inhibitor<br />
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== References ==
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**[[3bcj]], [[1x97]], [[1x98]], [[1pwm]], [[1ef3]], [[2pd5]], [[2dux]], [[2duz]], [[2dv0]], [[2fz8]], [[2fz9]], [[2hv5]], [[2hvn]], [[2hvo]], [[1mar]], [[2fzb]], [[2fzd]], [[1z3n]], [[1pwl]], [[1iei]], [[4jir]] - hAldR+NADP+inhibitor for diabetic treatment<br />
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<references/>
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**[[1z89]], [[1z8a]] - hAldR+NADP+sulfonyl-pyridazinone<br />
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**[[2pdg]], [[2pdh]] - hAldR+NADP+uracil inhibitor<br />
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**[[2j8t]], [[1x96]], [[2acs]], [[2acu]] - hAldR+NADP+citrate<br />
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**[[2acq]] - hAldR +NADP+glucose phosphate<br />
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**[[2acr]] - hAldR +NADP+cacodylate<br />
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**[[2ikg]], [[2ikh]], [[2ikj]], [[3v35]] - hAldR+NADP+nitro-substituted inhibitor<br />
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**[[3v36]] - hAldR+NADP+ glyceraldehyde + azine<br />
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**[[2nvc]], [[2nvd]] - hAldR+NADP+isothiazole inhibitor<br />
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**[[3p2v]] - hAldR+NADP+ benzothiazepine inhibitor<br />
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**[[2pev]], [[2pf8]], [[2pfh]] - hAldR+NADP+IDD inhibitor+ fidarestat<br />
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**[[2ipw]], [[2iq0]], [[2iqd]], [[2isf]], [[2ine]], [[2inz]], [[2is7]] - hAldR+NADP+ acid<br />
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**[[2f2k]] - hAldR+NADP+DEG<br />
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**[[2pdn]], [[2pdq]] – hAldR (mutant)+NADP+uracil inhibitor<br />
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**[[2pdb]], [[2pdf]], [[2pdi]], [[2pdm]], [[2pdx]], [[3len]], [[3m0i]], [[3mb9]], [[2pd9]], [[2pdw]], [[2pdy]], [[2agt]], [[2pdl]] – hAldR (mutant)+NADP+inhibitor for diabetic treatment<br />
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**[[2pdk]] - hAldR (mutant)+NADP+sorbinil<br />
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**[[1az1]] – hAldR (mutant)+NADP+alrestatin<br />
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**[[1az2]] - hAldR (mutant)+NADP+citrate<br />
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**[[3lbo]], [[3ld5]], [[3lql]], [[3lz5]], [[2pdc]], [[3lep]], [[3lqg]], [[3lz3]], [[3m4h]], [[2pdj]], [[2pdp]], [[2pdu]], [[3m64]], [[3mc5]] - hAldR (mutant)+IDD inhibitors<br />
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**[[3dn5]] – hAldR+NADP+biaryl inhibitor<br />
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**[[3v9q]] - hAldR+NADP+ phenol derivative<br />
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**[[3rx2]], [[3rx3]], [[3rx4]], [[3s3g]] - hAldR+NADP+ sulindac inhibitor<br />
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**[[4igs]] - hAldR+NADP+ polyfluorinated inhibitor<br />
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**[[4lau]], [[4laz]], [[4lb3]], [[4lb4]], [[4lbr]], [[4lbs]] - hAldR+NADP+ carbamoyl inhibitor<br />
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**[[3fx4]] – pAldR+NADP+thiazolidine derivative <br />
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**[[3h4g]] – pAldR+NADP+fidarestat<br />
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**[[1ah3]], [[1ae4]] - pAldR+NADP+tolrestat<br />
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**[[1ah0]] - pAldR+NADP+sorbinil<br />
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**[[1eko]] - pAldR+NADP+IDD inhibitor<br />
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**[[2vdg]] – bAldR+NADP+butanol <br />
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}}
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[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Human aldose reductase complex with cofactor NADP (PDB code 1ads)

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References

  1. ↑ Rondeau JM, Tete-Favier F, Podjarny A, Reymann JM, Barth P, Biellmann JF, Moras D. Novel NADPH-binding domain revealed by the crystal structure of aldose reductase. Nature. 1992 Jan 30;355(6359):469-72. PMID:1734286 doi:http://dx.doi.org/10.1038/355469a0
  2. ↑ Wilson DK, Bohren KM, Gabbay KH, Quiocho FA. An unlikely sugar substrate site in the 1.65 A structure of the human aldose reductase holoenzyme implicated in diabetic complications. Science. 1992 Jul 3;257(5066):81-4. PMID:1621098

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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