Guanylate kinase

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== Structural highlights ==
== Structural highlights ==
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The GMP binding site of GK is located between its nucleoside monophosphate-binding domain and the LID domain<ref>PMID:16140325</ref>.
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The biological assembly of ''E. coli'' guanylate kinase is <scene name='48/487529/Cv/9'>homohexamer</scene>. The <scene name='48/487529/Cv/10'>GMP binding site</scene> of GK is <scene name='48/487529/Cv/8'>located between its nucleoside monophosphate-binding domain and the LID domain</scene><ref>PMID:16140325</ref>.
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</StructureSection>
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==3D structures of guanylate kinase==
==3D structures of guanylate kinase==
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[[Guanylate kinase 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Guanylate kinase
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**[[1ex6]], [[4f4j]] – yGK – yeast<br />
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**[[3sqk]] – yGK (mutant)<br />
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**[[1s4q]], [[1znw]] – MtGK – ''Mycobacterium tuberculosis''<br />
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**[[1z8f]] – MtGK (mutant)<br />
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**[[1s96]], [[2anc]] – EcGK – ''Escherichia coli''<br />
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**[[1z6g]] – GK – ''Plasmodium falciparum''
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*Guanylate kinase binary complex
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**[[1gky]], [[1ex7]] – yGK + GMP <br />
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**[[1lvg]] – GK + ADP + GMP – mouse<br />
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**[[2an9]] – EcGK + guanosine + GDP<br />
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**[[2anb]] – EcGK + GMP<br />
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**[[2f3t]] – EcGK + GMP derivative<br />
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**[[2f3r]] – EcGK + adenosyl-guanosyl pentaphosphate<br />
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**[[1znx]] – MtGK + GMP<br />
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**[[1zny]], [[1znz]] – MtGK + GDP<br />
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**[[2j41]] – SaGK + GMP – ''Staphylococcus aureus''<br />
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**[[4qrh]] - SaGK + (P)PPGPP<br />
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**[[2qor]] - GK + GMP – ''Plasmodium vivax''<br />
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**[[3lnc]] - GK + GMP – ''Anaplasma phagocytophilum''<br />
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**[[3tr0]] – GK residues 1-202 + GMP – ''Coxiella burnetii''
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*Membrane-associated guanylate kinase
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**[[1uep]] – hMAGUK PDZ domain 3 – human – NMR<BR />
 
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**[[1ueq]], [[2kpk]] - hMAGUK PDZ domain 1 – NMR<BR />
 
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**[[1ujv]] - hMAGUK PDZ domain 2 – NMR<BR />
 
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**[[3bpu]] - hMAGUK PDZ domain 3 (mutant)<br />
 
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**[[3soe]] - hMAGUK PDZ domain 3<br />
 
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**[[2q9v]] - hMAGUK PDZ domain 4<br />
 
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**[[1uew]] - hMAGUK PDZ domain 4 – NMR<BR />
 
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**[[1wfv]] - hMAGUK PDZ domain 5 – NMR<BR />
 
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**[[2r4h]] - hMAGUK PDZ domain 6 (mutant)<br />
 
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**[[2i04]] - hMAGUK PDZ domain 1 + papillomavirus peptide<br />
 
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**[[2kpl]] - hMAGUK PDZ domain 1 + protein E6 peptide]] - NMR<BR />
 
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**[[2ysd]], [[2yse]] - hMAGUK WW domain – NMR<BR />
 
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**[[2zaj]] - hMAGUK WW 2 domain – NMR<BR />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

E. coli guanylate kinase complex with GMP, sulfate (PDB entry 2anb)

Drag the structure with the mouse to rotate

References

  1. ↑ Johnston CA, Whitney DS, Volkman BF, Doe CQ, Prehoda KE. Conversion of the enzyme guanylate kinase into a mitotic-spindle orienting protein by a single mutation that inhibits GMP-induced closing. Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):E973-8. Epub 2011 Oct 11. PMID:21990344 doi:10.1073/pnas.1104365108
  2. ↑ Hible G, Renault L, Schaeffer F, Christova P, Zoe Radulescu A, Evrin C, Gilles AM, Cherfils J. Calorimetric and crystallographic analysis of the oligomeric structure of Escherichia coli GMP kinase. J Mol Biol. 2005 Oct 7;352(5):1044-59. PMID:16140325 doi:10.1016/j.jmb.2005.07.042

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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