Sialyltransferase

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Revision as of 13:20, 11 September 2019

α-2,3-sialyltransferase complex with trisaccharide, acetate, MPD and ethylene glycol (PDB code 2x61)

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Updated on 11-September-2019

↑ Schwartz-Albiez R, Merling A, Martin S, Haas R, Gross HJ. Cell surface sialylation and ecto-sialyltransferase activity of human CD34 progenitors from peripheral blood and bone marrow. Glycoconj J. 2004;21(8-9):451-9. PMID:15750786 doi:http://dx.doi.org/10.1007/s10719-004-5535-5
↑ Harduin-Lepers A, Vallejo-Ruiz V, Krzewinski-Recchi MA, Samyn-Petit B, Julien S, Delannoy P. The human sialyltransferase family. Biochimie. 2001 Aug;83(8):727-37. PMID:11530204
↑ Wang L, Liu Y, Wu L, Sun XL. Sialyltransferase inhibition and recent advances. Biochim Biophys Acta. 2016 Jan;1864(1):143-53. doi: 10.1016/j.bbapap.2015.07.007., Epub 2015 Jul 18. PMID:26192491 doi:http://dx.doi.org/10.1016/j.bbapap.2015.07.007
↑ Lee HJ, Lairson LL, Rich JR, Lameignere E, Wakarchuk WW, Withers SG, Strynadka NC. Structural and kinetic analysis of substrate binding to the sialyltransferase CST-II from Campylobacter Jejuni. J Biol Chem. 2011 Aug 8. PMID:21832050 doi:10.1074/jbc.M111.261172

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 == Structural highlights ==
-The biological assembly of α-2,3-sialyltransferase is <scene name='74/748880/Cv/2'>homotetramer</scene> ([[2x61]]). The <scene name='74/748880/Cv/6'>trisaccharide acceptor binds to the open cleft</scene> at the C-terminal of SIT<ref>PMID:21832050</ref>. <scene name='74/748880/Cv/3'>Trisaccharide binding site</scene>. Water molecules shown as red spheres.
+The biological assembly of α-2,3-sialyltransferase is <scene name='74/748880/Cv/8'>homotetramer</scene> ([[2x61]]). The <scene name='74/748880/Cv/9'>trisaccharide acceptor binds to the open cleft</scene> at the C-terminal of SIT<ref>PMID:21832050</ref>. <scene name='74/748880/Cv/10'>Trisaccharide binding site</scene>. Water molecules are shown as red spheres.
 </StructureSection>