Thioredoxin Reductase

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== Structural highlights ==
== Structural highlights ==
TrxR and Trx form an <scene name='43/433123/Cv/6'>intramolecular Cys-Cys bond</scene><ref>PMID:21750537</ref>. <scene name='43/433123/Cv/7'>FAD binding site</scene>. Water molecules are shown as red spheres.
TrxR and Trx form an <scene name='43/433123/Cv/6'>intramolecular Cys-Cys bond</scene><ref>PMID:21750537</ref>. <scene name='43/433123/Cv/7'>FAD binding site</scene>. Water molecules are shown as red spheres.
 +
== 3D Structures of Thioredoxin Reductase ==
 +
[[Thioredoxin reductase 3D structures]]
</StructureSection>
</StructureSection>
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*Thioredoxin reductase complex with FAD
*Thioredoxin reductase complex with FAD
-
**[[1cl0]], [[1tde]], [[1trb]], [[4o5q]], [[4o5u]] – EcTrxR+FAD – ''Eschericia coli''<br />
 
**[[1vdc]] – TrxR+FAD – ''Arabidopsis thaliana''<br />
**[[1vdc]] – TrxR+FAD – ''Arabidopsis thaliana''<br />
 +
**[[1cl0]], [[1tde]], [[1trb]], [[4o5q]], [[4o5u]] – EcTrxR+FAD – ''Eschericia coli''<br />
**[[3cty]] - TrxR+FAD – ''Thermoplasma acidophilum''<br />
**[[3cty]] - TrxR+FAD – ''Thermoplasma acidophilum''<br />
**[[2zbw]] – TrxR + FAD – ''Thermus thermophilus''<br />
**[[2zbw]] – TrxR + FAD – ''Thermus thermophilus''<br />
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**[[5uwy]] – TrxR + FAD – ''Streptococcus pyogenes''<br />
**[[5uwy]] – TrxR + FAD – ''Streptococcus pyogenes''<br />
**[[5uwy]] – TrxR + FAD – ''Cypptococcus neoformans''<br />
**[[5uwy]] – TrxR + FAD – ''Cypptococcus neoformans''<br />
 +
**[[6gna]], [[6gnb]], [[6gnc]] – CaTrxR + FAD – ''Clostridium acetobutylicum''<br />
 +
**[[6gnd]] – CaTrxR + FAD + Trx<br />
 +
**[[5w4c]] – TrxR + FAD – ''Cryprococcus neoformans''<br />
 +
**[[5nii]] – TrxR + FAD – ''Desulfovibrio vulgaris''<br />
*Thioredoxin reductase complex with FAD and NADP
*Thioredoxin reductase complex with FAD and NADP
-
**[[1tdf]] - EcTrxR+FAD+NADPH<br />
 
-
**[[1f6m]] - EcTrxR (mutant)+Trx-1+FAD+AADPH<br />
 
**[[1h6v]] – rTrxR (mutant)+FAD+NADPH – rat<br />
**[[1h6v]] – rTrxR (mutant)+FAD+NADPH – rat<br />
-
**[[2a87]] - MtTrxR+FAD+NADPH <br />
 
-
**[[3d8x]] - yTrxR+FAD+NADPH - yeast<br />
 
**[[2nvk]] - DmTrxR+FAD+NADPH – ''Drosophila melanogaster''<br />
**[[2nvk]] - DmTrxR+FAD+NADPH – ''Drosophila melanogaster''<br />
 +
**[[3d8x]] - yTrxR+FAD+NADPH - yeast<br />
 +
**[[1tdf]] - EcTrxR+FAD+NADPH<br />
 +
**[[1f6m]] - EcTrxR (mutant)+Trx-1+FAD+NADPH analog<br />
 +
**[[2a87]] - MtTrxR+FAD+NADPH <br />
**[[2q0k]], [[2q0l]] - HpTrxR+FAD+NADPH <br />
**[[2q0k]], [[2q0l]] - HpTrxR+FAD+NADPH <br />
-
**[[4a5l]], [[4up3]], [[4cbq]] - EhTrxR+FAD+NADPH <br />
+
**[[4a5l]], [[4up3]], [[4cbq]] - EhTrxR+FAD+NADPH - ''Entamoeba histolyca''<br />
**[[4a65]] - EhTrxR+FAD+NADPH + Au<br />
**[[4a65]] - EhTrxR+FAD+NADPH + Au<br />
**[[4ccq]] - EhTrxR+NADPH<br />
**[[4ccq]] - EhTrxR+NADPH<br />
**[[4gcm]] - SaTrxR+FAD+NADPH – ''Staphylococcus aureus''<br />
**[[4gcm]] - SaTrxR+FAD+NADPH – ''Staphylococcus aureus''<br />
**[[5mh4]], [[5mjk]], [[5mip]], [[5miq]], [[5mir]], [[5mis]], [[5mit]] – TrxR + FAD + NAPD – ''Lactococcus lactis''<br />
**[[5mh4]], [[5mjk]], [[5mip]], [[5miq]], [[5mir]], [[5mis]], [[5mit]] – TrxR + FAD + NAPD – ''Lactococcus lactis''<br />
-
**[[5usx]], [[5vt3]] – VvTrxR + FAD + NAPD <br />
+
**[[5usx]], [[5vt3]] – VvTrxR + FAD + NAPD - ''Vibrio vulnificus''<br />
 +
**[[6bpy]] – TrxR + FAD + NADP – ''Neosartorya fumigata''<br />
*Thioredoxin reductase 1
*Thioredoxin reductase 1
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**[[2j3n]] – hTrxR-1+FAD+NADPH<br />
**[[2j3n]] – hTrxR-1+FAD+NADPH<br />
**[[3qfa]], [[3qfb]] - hTrxR-1 (mutant) +FAD+ Trx<br />
**[[3qfa]], [[3qfb]] - hTrxR-1 (mutant) +FAD+ Trx<br />
-
**[[3itj]] – yTrxR-1+FAD <br />
 
-
**[[3dh9]], [[3dgh]] – DmTrxR-1+FAD<br />
 
**[[4kpr]] - rTrxR-1 +FAD<br />
**[[4kpr]] - rTrxR-1 +FAD<br />
-
**[[3ean]], [[3eao]] – rTrxR-1+FAD+NADPH
+
**[[3ean]], [[3eao]] – rTrxR-1+FAD+NADPH<br />
 +
**[[3dh9]], [[3dgh]] – DmTrxR-1+FAD<br />
 +
**[[3itj]] – yTrxR-1+FAD <br />
*Thioredoxin reductase 2
*Thioredoxin reductase 2
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**[[1zdl]], [[1zkq]] – mTrxR-2+FAD+NADPH – mouse<br />
**[[1zdl]], [[1zkq]] – mTrxR-2+FAD+NADPH – mouse<br />
**[[3dgz]] – mTrxR-2 + FAD<br />
**[[3dgz]] – mTrxR-2 + FAD<br />
 +
**[[4owy]] – yTrxR-2 <br />
**[[6a4j]] – SaTrxR-2 + FAD<br />
**[[6a4j]] – SaTrxR-2 + FAD<br />
**[[2whd]] – TrxR-2+FAD – ''Hordeum vulgare''<br />
**[[2whd]] – TrxR-2+FAD – ''Hordeum vulgare''<br />
**[[4j56]], [[4j57]] - PfTrxR-2 (mutant) + Trx (mutant) +FAD<br />
**[[4j56]], [[4j57]] - PfTrxR-2 (mutant) + Trx (mutant) +FAD<br />
-
**[[4owy]] – yTrxR-2 <br />
 
*Thioredoxin reductase 3
*Thioredoxin reductase 3
-
**[[3f8d]], [[3f8p]], [[3f8r]] – TrxR-3 (mutant)+FAD – ''Sulfolobus solfataricus''<br />
 
**[[3h8q]] – hTrxR-3 glutaredoxin domain<br />
**[[3h8q]] – hTrxR-3 glutaredoxin domain<br />
**[[2lv3]] - mTrxR-3 glutaredoxin domain<br />
**[[2lv3]] - mTrxR-3 glutaredoxin domain<br />
 +
**[[3f8d]], [[3f8p]], [[3f8r]] – TrxR-3 (mutant)+FAD – ''Sulfolobus solfataricus''<br />
 +
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:38, 23 February 2020

Human Thioredoxin reductase dimer (cyan, green) complex with thioredoxin (yellow, pink), glycerol and FAD (PDB entry 3qfa)

Drag the structure with the mouse to rotate

3D Structures of Thioredoxin Reductase

Updated on 23-February-2020

References

  1. ↑ Arner ES, Holmgren A. Physiological functions of thioredoxin and thioredoxin reductase. Eur J Biochem. 2000 Oct;267(20):6102-9. PMID:11012661
  2. ↑ Prasad R, Chan LF, Hughes CR, Kaski JP, Kowalczyk JC, Savage MO, Peters CJ, Nathwani N, Clark AJ, Storr HL, Metherell LA. Thioredoxin Reductase 2 (TXNRD2) mutation associated with familial glucocorticoid deficiency (FGD). J Clin Endocrinol Metab. 2014 Aug;99(8):E1556-63. doi: 10.1210/jc.2013-3844. Epub, 2014 Mar 6. PMID:24601690 doi:http://dx.doi.org/10.1210/jc.2013-3844
  3. ↑ Fritz-Wolf K, Kehr S, Stumpf M, Rahlfs S, Becker K. Crystal structure of the human thioredoxin reductase-thioredoxin complex. Nat Commun. 2011 Jul 12;2:383. doi: 10.1038/ncomms1382. PMID:21750537 doi:10.1038/ncomms1382

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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