Bifunctional purine biosynthesis protein PURH

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== Structural highlights ==
== Structural highlights ==
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The 3D structure of human PURH shows the XMP nucleotide bound in the IMP cyclohydrolase domain and the activator AICAR and the inhibitor bound at the interface of dimer making numerous interactions with both PHRH monomers<ref>PMID:14966129</ref>.
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The 3D structure of human PURH shows the <scene name='84/842877/Cv/4'>XMP nucleotide bound in the IMP cyclohydrolase domain</scene> and the activator AICAR and the inhibitor bound at the interface of dimer making numerous interactions with both PHRH monomers<ref>PMID:14966129</ref>.
</StructureSection>
</StructureSection>

Revision as of 13:35, 7 May 2020

Human PURH dimer complex with activator AICAR, XMP, inhibitor and K+ ion (purple) (PDB code 1p4r)

Drag the structure with the mouse to rotate

3D structures of bifunctional purine biosynthesis protein PURH

Updated on 07-May-2020

1pkx - hPURH + XMP - human
5uy8, 5uz0 - hPURH + AICAR + inhibitor
1p4r, 1pl0 - hPURH + AICAR + XMP + inhibitor
1oz0 - cPURH - chicken
1thz, 2iu3, 2iu0, 2b1g, 2b1i - cPURH + inhibitor
1m9n - cPURH + AICAR + XMP
1zcz - PURH - Thermotoga maritima
3zzm - MtPURH + CFAIR - Mycobacterium tuberculosis
4a1o - MtPURH + AICAR + CFAIR
2ntm - MetPURH - Methanothermobacter thermautotrophicus
2ntl - MetPURH + AICAR
2ntk - MetPURH + IMP

References

  1. ↑ Qiu X, Yuan Y, Gao Y. Expression, purification, crystallization and preliminary X-ray diffraction crystallographic study of PurH from Escherichia coli. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Dec 1;67(Pt 12):1590-4., doi: 10.1107/S1744309111039960. Epub 2011 Nov 26. PMID:22139174 doi:http://dx.doi.org/10.1107/S1744309111039960
  2. ↑ McGuire JJ. Anticancer antifolates: current status and future directions. Curr Pharm Des. 2003;9(31):2593-613. doi: 10.2174/1381612033453712. PMID:14529544 doi:http://dx.doi.org/10.2174/1381612033453712
  3. ↑ Cheong CG, Wolan DW, Greasley SE, Horton PA, Beardsley GP, Wilson IA. Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates. J Biol Chem. 2004 Apr 23;279(17):18034-45. Epub 2004 Feb 13. PMID:14966129 doi:10.1074/jbc.M313691200

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