Squalene-hopene cyclase
From Proteopedia
(Difference between revisions)
| (9 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | <StructureSection load='1ump' size=' | + | <StructureSection load='1ump' size='350' side='right' caption='Structure of squalene-hopene cyclase complex with 2-azasqualene and detergent (PDB code [[1ump]]).' scene='59/591998/Cv/1'> |
== Function == | == Function == | ||
| - | '''Squalene-hopene cyclase''' (SHC) catalyzes the conversion of acyclic squalene into the pentacyclic hopene and hopanol in prokaryotes. The reaction which SHC cactalyzes involves the breaking or forming of 13 covalent bonds, the formation of 9 chiral centers and the formation of 5 rings in a single step. | + | '''Squalene-hopene cyclase''' or '''oxidosqualene cyclase''' (SHC) catalyzes the conversion of acyclic squalene into the pentacyclic hopene and hopanol in prokaryotes. The reaction which SHC cactalyzes involves the breaking or forming of 13 covalent bonds, the formation of 9 chiral centers and the formation of 5 rings in a single step<ref>PMID:25503928</ref>. |
| - | + | ||
| - | + | ||
== Relevance == | == Relevance == | ||
| Line 12: | Line 10: | ||
== Structural highlights == | == Structural highlights == | ||
| + | The <scene name='59/591998/Cv/6'>active site of SHC binds the close substrate analog azosqualene</scene><ref>PMID:15113001</ref>. Water molecules are shown as red spheres. | ||
| + | </StructureSection> | ||
==3D structures of squalene-hopene cyclase== | ==3D structures of squalene-hopene cyclase== | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| + | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | + | *Squalene-hopene cyclase | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | **[[1sqc]] – AaSHC – ''Alicyclobacillus acidocaldarius''<br /> | |
| + | **[[2sqc]], [[3sqc]] – AaSHC (mutant)<br /> | ||
| - | + | *Squalene-hopene cyclase complexes | |
| - | + | ||
| - | + | ||
| + | **[[1gsz]] – AaSHC + drug<br /> | ||
| + | **[[1h35]], [[1h36]], [[1h37]], [[1h39]], [[1h3a]], [[1h3b]], [[1h3c]], [[1o6h]], [[1o6q]], [[1o6r]], [[1o79]] – AaSHC + inhibitor<br /> | ||
| + | **[[1ump]] – AaSHC + 2-azasqualene<br /> | ||
| + | }} | ||
== References == | == References == | ||
Current revision
| |||||||||||
3D structures of squalene-hopene cyclase
Updated on 09-November-2020
References
- ↑ Hammer SC, Marjanovic A, Dominicus JM, Nestl BM, Hauer B. Squalene hopene cyclases are protonases for stereoselective Bronsted acid catalysis. Nat Chem Biol. 2015 Feb;11(2):121-6. doi: 10.1038/nchembio.1719. Epub 2014 Dec, 15. PMID:25503928 doi:http://dx.doi.org/10.1038/nchembio.1719
- ↑ Reinert DJ, Balliano G, Schulz GE. Conversion of squalene to the pentacarbocyclic hopene. Chem Biol. 2004 Jan;11(1):121-6. PMID:15113001 doi:http://dx.doi.org/10.1016/j.chembiol.2003.12.013
