|
|
| (3 intermediate revisions not shown.) |
| Line 1: |
Line 1: |
| | | | |
| | ==Structure of the DP10.7 TCR== | | ==Structure of the DP10.7 TCR== |
| - | <StructureSection load='4mnh' size='340' side='right' caption='[[4mnh]], [[Resolution|resolution]] 3.30Å' scene=''> | + | <StructureSection load='4mnh' size='340' side='right'caption='[[4mnh]], [[Resolution|resolution]] 3.30Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[4mnh]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MNH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MNH FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4mnh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MNH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MNH FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4mng|4mng]]</td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mnh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mnh OCA], [https://pdbe.org/4mnh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mnh RCSB], [https://www.ebi.ac.uk/pdbsum/4mnh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mnh ProSAT]</span></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TRGV3, TCRB, B2M, HDCMA22P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), TRA@ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
| + | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mnh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mnh OCA], [http://pdbe.org/4mnh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mnh RCSB], [http://www.ebi.ac.uk/pdbsum/4mnh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mnh ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/K7N5M4_HUMAN K7N5M4_HUMAN] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
| Line 19: |
Line 19: |
| | | | |
| | ==See Also== | | ==See Also== |
| - | *[[T-cell receptor|T-cell receptor]] | + | *[[T-cell receptor 3D structures|T-cell receptor 3D structures]] |
| | == References == | | == References == |
| | <references/> | | <references/> |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Human]] | + | [[Category: Homo sapiens]] |
| - | [[Category: Adams, E J]] | + | [[Category: Large Structures]] |
| - | [[Category: Luoma, A M]] | + | [[Category: Adams EJ]] |
| - | [[Category: Activation]] | + | [[Category: Luoma AM]] |
| - | [[Category: Cd1d]]
| + | |
| - | [[Category: Cell-surface receptor]]
| + | |
| - | [[Category: Gamma delta t cell]]
| + | |
| - | [[Category: Glycolipid]]
| + | |
| - | [[Category: Glycoprotein]]
| + | |
| - | [[Category: Histocompatibility antigen]]
| + | |
| - | [[Category: Immune system]]
| + | |
| - | [[Category: Immunoglobulin]]
| + | |
| - | [[Category: Immunological]]
| + | |
| - | [[Category: Intraepithelial lymphocyte]]
| + | |
| - | [[Category: Lymphocyte]]
| + | |
| - | [[Category: Non-classical mhc]]
| + | |
| - | [[Category: T cell receptor]]
| + | |
| - | [[Category: T cell recognition]]
| + | |
| Structural highlights
Function
K7N5M4_HUMAN
Publication Abstract from PubMed
The nature of the antigens recognized by gammadelta T cells and their potential recognition of major histocompatibility complex (MHC)-like molecules has remained unclear. Members of the CD1 family of lipid-presenting molecules are suggested ligands for Vdelta1 TCR-expressing gammadelta T cells, the major gammadelta lymphocyte population in epithelial tissues. We crystallized a Vdelta1 TCR in complex with CD1d and the self-lipid sulfatide, revealing the unusual recognition of CD1d by germline Vdelta1 residues spanning all complementarity-determining region (CDR) loops, as well as sulfatide recognition separately encoded by nongermline CDR3delta residues. Binding and functional analysis showed that CD1d presenting self-lipids, including sulfatide, was widely recognized by gut Vdelta1+ gammadelta T cells. These findings provide structural demonstration of MHC-like recognition of a self-lipid by gammadelta T cells and reveal the prevalence of lipid recognition by innate-like T cell populations.
Crystal Structure of Vdelta1 T Cell Receptor in Complex with CD1d-Sulfatide Shows MHC-like Recognition of a Self-Lipid by Human gammadelta T Cells.,Luoma AM, Castro CD, Mayassi T, Bembinster LA, Bai L, Picard D, Anderson B, Scharf L, Kung JE, Sibener LV, Savage PB, Jabri B, Bendelac A, Adams EJ Immunity. 2013 Dec 12;39(6):1032-42. doi: 10.1016/j.immuni.2013.11.001. Epub 2013, Nov 14. PMID:24239091[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Luoma AM, Castro CD, Mayassi T, Bembinster LA, Bai L, Picard D, Anderson B, Scharf L, Kung JE, Sibener LV, Savage PB, Jabri B, Bendelac A, Adams EJ. Crystal Structure of Vdelta1 T Cell Receptor in Complex with CD1d-Sulfatide Shows MHC-like Recognition of a Self-Lipid by Human gammadelta T Cells. Immunity. 2013 Dec 12;39(6):1032-42. doi: 10.1016/j.immuni.2013.11.001. Epub 2013, Nov 14. PMID:24239091 doi:http://dx.doi.org/10.1016/j.immuni.2013.11.001
|
