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1i25

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{{Seed}}
 
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[[Image:1i25.png|left|200px]]
 
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==Three dimensional solution structure of huwentoxin-II by 2D 1H-NMR==
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The line below this paragraph, containing "STRUCTURE_1i25", creates the "Structure Box" on the page.
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<StructureSection load='1i25' size='340' side='right'caption='[[1i25]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1i25]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cyriopagopus_schmidti Cyriopagopus schmidti]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I25 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I25 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i25 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i25 OCA], [https://pdbe.org/1i25 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i25 RCSB], [https://www.ebi.ac.uk/pdbsum/1i25 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i25 ProSAT]</span></td></tr>
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</table>
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{{STRUCTURE_1i25| PDB=1i25 | SCENE= }}
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== Function ==
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[https://www.uniprot.org/uniprot/TXH21_CYRSC TXH21_CYRSC] Lethal neurotoxin that blocks neuromuscular transmission. Acts cooperatively to potentiate the activity of huwentoxin-I. This toxin is active against insects.<ref>PMID:10424342</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The three-dimensional structure of huwentoxin-II (HWTX-II), an insecticidal peptide purified from the venom of spider Selenocosmia huwena with a unique disulfide bond linkage as I-III, II-V, and IV-VI, has been determined using 2D (1)H-NMR. The resulting structure of HWTX-II contains two beta-turns (C4-S7 and K24-W27) and a double-stranded antiparallel beta-sheet (W27-C29 and C34-K36). Although the C-terminal double-stranded beta-sheet cross-linked by two disulfide bonds (II-V and IV-VI in HWTX-II, II-V and III-VI in the ICK molecules) is conserved both in HWTX-II and the ICK molecules, the structure of HWTX-II is unexpected absence of the cystine knot because of its unique disulfide linkage. It suggests that HWTX-II adopts a novel scaffold different from the ICK motif that is adopted by all other spider toxin structures elucidated thus far. Furthermore, the structure of HWTX-II, which conforms to the disulfide-directed beta-hairpin (DDH) motif, not only supports the hypothesis that the ICK is a minor elaboration of the more ancestral DDH motif but also suggests that HWTX-II may have evolved from the same structural ancestor.
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===Three dimensional solution structure of huwentoxin-II by 2D 1H-NMR===
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The structure of spider toxin huwentoxin-II with unique disulfide linkage: evidence for structural evolution.,Shu Q, Lu SY, Gu XC, Liang SP Protein Sci. 2002 Feb;11(2):245-52. PMID:11790834<ref>PMID:11790834</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_11790834}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1i25" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 11790834 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_11790834}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Cyriopagopus schmidti]]
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1I25 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Ornithoctonus_huwena Ornithoctonus huwena]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I25 OCA].
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[[Category: Large Structures]]
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[[Category: Gu XC]]
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==Reference==
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[[Category: Liang SP]]
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The structure of spider toxin huwentoxin-II with unique disulfide linkage: evidence for structural evolution., Shu Q, Lu SY, Gu XC, Liang SP, Protein Sci. 2002 Feb;11(2):245-52. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11790834 11790834]
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[[Category: Lu SY]]
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[[Category: Ornithoctonus huwena]]
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[[Category: Shu Q]]
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[[Category: Single protein]]
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[[Category: Gu, X C.]]
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[[Category: Liang, S P.]]
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[[Category: Lu, S Y.]]
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[[Category: Shu, Q.]]
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[[Category: Disulfide bond]]
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[[Category: Insecticidal toxin]]
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[[Category: Neurotoxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:18:06 2008''
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Current revision

Three dimensional solution structure of huwentoxin-II by 2D 1H-NMR

PDB ID 1i25

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