7zzv
From Proteopedia
(Difference between revisions)
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<StructureSection load='7zzv' size='340' side='right'caption='[[7zzv]]' scene=''> | <StructureSection load='7zzv' size='340' side='right'caption='[[7zzv]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full | + | <table><tr><td colspan='2'>[[7zzv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZZV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZZV FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zzv OCA], [https://pdbe.org/7zzv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zzv RCSB], [https://www.ebi.ac.uk/pdbsum/7zzv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zzv ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zzv OCA], [https://pdbe.org/7zzv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zzv RCSB], [https://www.ebi.ac.uk/pdbsum/7zzv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zzv ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PPAP_HUMAN PPAP_HUMAN] A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.<ref>PMID:15280042</ref> <ref>PMID:18083097</ref> <ref>PMID:19403677</ref> <ref>PMID:20498373</ref> Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling.<ref>PMID:15280042</ref> <ref>PMID:18083097</ref> <ref>PMID:19403677</ref> <ref>PMID:20498373</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Acid phosphatase 3D structures|Acid phosphatase 3D structures]] | ||
| + | *[[Histone deacetylase 3D structures|Histone deacetylase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Blokhin DS]] | [[Category: Blokhin DS]] | ||
Revision as of 11:22, 14 June 2023
Prostatic acid phosphatase (PAP) fragment (85-120)
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