Peptide N-glycanase
From Proteopedia
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| - | <StructureSection load='2f4m' size='400' side='right' caption='Yeast PNGase catalytic domain (sky blue) complex with Rad23 (green), Zn+2 (grey) and Cl- (green) ions (PDB code [[2f4m]]).' scene='68/684794/Cv/ | + | <StructureSection load='2f4m' size='400' side='right' caption='Yeast PNGase catalytic domain (sky blue) complex with Rad23 (green), Zn+2 (grey) and Cl- (green) ions (PDB code [[2f4m]]).' scene='68/684794/Cv/4' pspeed='8'> |
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PNG F is used in studying of glycoproteins. | PNG F is used in studying of glycoproteins. | ||
== Structural highlights == | == Structural highlights == | ||
| - | *<scene name='68/684794/Cv/ | + | *<scene name='68/684794/Cv/5'>Zn coordination site contains 4 cysteins</scene>. |
| - | *<scene name='68/684794/Cv/ | + | *<scene name='68/684794/Cv/6'>Cl coordination site</scene>. |
</StructureSection> | </StructureSection> | ||
== 3D Structures of PNGase == | == 3D Structures of PNGase == | ||
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*PNGase F | *PNGase F | ||
| - | **[[1pgs]], [[1png]] – EmPNG – ''Elizabethkingia meningoseptica''<br /> | + | **[[1pgs]], [[1png]], [[3pms]] – EmPNG – ''Elizabethkingia meningoseptica''<br /> |
| + | **[[4r4x]], [[4r4z]] – EmPNG-II<br /> | ||
**[[1pnf]] – EmPNG + acetylchitobiose <br /> | **[[1pnf]] – EmPNG + acetylchitobiose <br /> | ||
}} | }} | ||
Current revision
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3D Structures of PNGase
Updated on 22-August-2023
References
- ↑ Tanabe K, Lennarz WJ, Suzuki T. A cytoplasmic peptide: N-glycanase. Methods Enzymol. 2006;415:46-55. PMID:17116467 doi:http://dx.doi.org/10.1016/S0076-6879(06)15004-1
- ↑ Norris GE, Stillman TJ, Anderson BF, Baker EN. The three-dimensional structure of PNGase F, a glycosylasparaginase from Flavobacterium meningosepticum. Structure. 1994 Nov 15;2(11):1049-59. PMID:7881905
- ↑ Suzuki T. The cytoplasmic peptide:N-glycanase (Ngly1)-basic science encounters a human genetic disorder. J Biochem. 2015 Jan;157(1):23-34. doi: 10.1093/jb/mvu068. Epub 2014 Nov 13. PMID:25398991 doi:http://dx.doi.org/10.1093/jb/mvu068
