Rho-associated protein kinase

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<StructureSection load='4yve' size='340' side='right' caption='Human ROCK1 kinase domain complex with thiazole inhibitor (PDB code [[4yve]])' scene=''>
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<StructureSection load='' size='350' side='right' caption='Human ROCK1 kinase domain complex with thiazole inhibitor (PDB code [[4yve]])' scene='75/752224/C/1' pspeed='8'>
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== Function ==
== Function ==
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'''Rho-associated protein kinase''' (ROCK) is a Rho GTPase effector. ROCK has been shown to regulate cadherin function and thus cell-cell adhesion<ref>PMID:22031287</ref>. ROCKs phosphorylate a large number of actin-binding proteins to modulate their functions.
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'''Rho-associated protein kinase''' (ROCK) is a Rho GTPase effector. ROCK has been shown to regulate cadherin function and thus cell-cell adhesion<ref>PMID:22031287</ref>. ROCKs phosphorylate a large number of actin-binding proteins to modulate their functions. ROCKs are kinases belonging to the AGC (PKA/ PKG/PKC) family of [[serine-threonine specific protein kinases]].
== Disease ==
== Disease ==
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== Structural highlights ==
== Structural highlights ==
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ROCK contains several domains including (in ROCK1) a kinase domain (residues 76-338); a coiled-coil region (residues 339-1103) which contains a Rho-binding domain (residues 934-1015) and a pleckstrin homology and cysteine-rich domain (residues 1103-1320) at the C-terminal. ROCK1 inhibitor binds in a pocket making interactions with a glycine-rich loop<ref>PMID:26039570</ref>.
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ROCK contains several domains including (in ROCK1) a kinase domain (residues 76-338); a coiled-coil region (residues 339-1103) which contains a Rho-binding domain (residues 934-1015) and a pleckstrin homology and cysteine-rich domain (residues 1103-1320) at the C-terminal. <scene name='75/752224/Cv/4'>ROCK1 inhibitor binds in a pocket</scene> making interactions with a <scene name='75/752224/Cv/5'>glycine-rich loop</scene><ref>PMID:26039570</ref>.
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</StructureSection>
 
==3D structures of Rho-associated protein kinase==
==3D structures of Rho-associated protein kinase==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[Rho-associated protein kinase 3D structures]]
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Rho-associated protein kinase 1
 
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**[[4l2w]] – hROCK1 Shroom-binding domain - human<br />
 
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**[[3o0z]] – hROCK1 coiled-coil domain <br />
 
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**[[1uix]] – hROCK1 Rho-binding domain <br />
 
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**[[5hvu]], [[4yvc]], [[4yve]], [[5bml]], [[4w7p]], [[3twj]], [[3tv7]], [[3v8s]], [[3ncz]], [[3ndm]], [[3d9v]], [[2esm]], [[2etk]], [[2etr]] – hROCK1 kinase domain + inhibitor <br />
 
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**[[5f5p]] – hROCK1 Shroom-binding domain + Shroom2 <br />
 
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**[[2v55]] – hROCK1 kinase domain + RhoE + GDP + ANP <br />
 
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**[[1s1c]] – hROCK1 Rho-binding domain + RhoA + GNP<br />
 
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*Rho-associated protein kinase 2
 
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**[[2f2u]] – hROCK2 kinase domain <br />
 
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**[[4wot]], [[4l6q]], [[2h9v]] – hROCK2 kinase domain + inhibitor <br />
 
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**[[2rov]] – hROCK2 split PH domain - NMR<br />
 
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**[[2row]] – hROCK2 C1 domain - NMR<br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
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[[Category:Topic Page]]

Current revision

Human ROCK1 kinase domain complex with thiazole inhibitor (PDB code 4yve)

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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