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1ul2

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{{Seed}}
 
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[[Image:1ul2.png|left|200px]]
 
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==Solution Conformation of alpha-Conotoxin GIC==
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The line below this paragraph, containing "STRUCTURE_1ul2", creates the "Structure Box" on the page.
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<StructureSection load='1ul2' size='340' side='right'caption='[[1ul2]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ul2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_geographus Conus geographus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UL2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UL2 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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{{STRUCTURE_1ul2| PDB=1ul2 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ul2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ul2 OCA], [https://pdbe.org/1ul2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ul2 RCSB], [https://www.ebi.ac.uk/pdbsum/1ul2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ul2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CA1C_CONGE CA1C_CONGE] Alpha-conotoxins bind to the nicotinic acetylcholine receptors (nAChR) and inhibit them. This toxin reversibly blocks neuronal nAChRs (alpha-3/beta-2 = alpha-6 or -3/beta-2 or -3 > alpha-3/beta-4 = alpha-4/beta-2).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Alpha-conotoxin GIC is a 16-residue peptide isolated from the venom of the cone snail Conus geographus. Alpha-conotoxin GIC potently blocks the alpha3beta2 subtype of human nicotinic acetylcholine receptor, showing a high selectivity for neuronal versus muscle subtype [McIntosh, Dowell, Watkins, Garrett, Yoshikami, and Olivera (2002) J. Biol. Chem. 277, 33610-33615]. We have now determined the three-dimensional solution structure of alpha-conotoxin GIC by NMR spectroscopy. The structure of alpha-conotoxin GIC is well defined with backbone and heavy atom root mean square deviations (residues 2-16) of 0.53 A and 0.96 A respectively. Structure and surface comparison of alpha-conotoxin GIC with the other alpha4/7 subfamily conotoxins reveals unique structural aspects of alpha-conotoxin GIC. In particular, the structural comparison between alpha-conotoxins GIC and MII indicates molecular features that may confer their similar receptor specificity profile, as well as those that provide the unique binding characteristics of alpha-conotoxin GIC.
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===Solution Conformation of alpha-Conotoxin GIC===
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Solution conformation of alpha-conotoxin GIC, a novel potent antagonist of alpha3beta2 nicotinic acetylcholine receptors.,Chi SW, Kim DH, Olivera BM, McIntosh JM, Han KH Biochem J. 2004 Jun 1;380(Pt 2):347-52. PMID:14992691<ref>PMID:14992691</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_14992691}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1ul2" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 14992691 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_14992691}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Conus geographus]]
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1UL2 is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UL2 OCA].
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[[Category: Large Structures]]
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[[Category: Chi S-W]]
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==Reference==
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[[Category: Han K-H]]
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Solution conformation of alpha-conotoxin GIC, a novel potent antagonist of alpha3beta2 nicotinic acetylcholine receptors., Chi SW, Kim DH, Olivera BM, McIntosh JM, Han KH, Biochem J. 2004 Jun 1;380(Pt 2):347-52. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14992691 14992691]
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[[Category: Kim D-H]]
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[[Category: Single protein]]
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[[Category: McIntosh JM]]
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[[Category: Chi, S W.]]
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[[Category: Olivera BM]]
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[[Category: Han, K H.]]
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[[Category: Kim, D H.]]
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[[Category: McIntosh, J M.]]
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[[Category: Olivera, B M.]]
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[[Category: Alpha-helix]]
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[[Category: Beta-turn]]
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[[Category: C-terminal amidation]]
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[[Category: Two disulfide bond]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:51:32 2008''
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Current revision

Solution Conformation of alpha-Conotoxin GIC

PDB ID 1ul2

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