This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6i6l
From Proteopedia
(Difference between revisions)
m (Protected "6i6l" [edit=sysop:move=sysop]) |
|||
| (3 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Papaver somniferum O-methyltransferase 1== | |
| - | + | <StructureSection load='6i6l' size='340' side='right'caption='[[6i6l]], [[Resolution|resolution]] 1.29Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6i6l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Papaver_somniferum Papaver somniferum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I6L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6I6L FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.29Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=H68:Tetrahydrocolumbamine'>H68</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6i6l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i6l OCA], [https://pdbe.org/6i6l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6i6l RCSB], [https://www.ebi.ac.uk/pdbsum/6i6l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6i6l ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/SOMT1_PAPSO SOMT1_PAPSO] Methyltransferase involved in the biosynthesis of the benzylisoquinoline alkaloid noscapine (PubMed:22535422, PubMed:22653730, PubMed:29610307). Catalyzes the conversion of (S)-scoulerine to (S)-tetrahydrocolumbamine (PubMed:22535422, PubMed:22653730). Can convert (S)-tetrahydrocolumbamine to tetrahydropalmatine (PubMed:22535422). Can convert (S)-norreticuline to (S)-norcodamine (PubMed:22535422). Can convert (S)-reticuline to (S)-codamine (PubMed:22535422). Substrate preference is (S)-scoulerine > (S)-tetrahydrocolumbamine > (S)-norreticuline > (S)-reticuline (PubMed:22535422).<ref>PMID:22535422</ref> <ref>PMID:22653730</ref> <ref>PMID:29610307</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Papaver somniferum]] | ||
| + | [[Category: Cabry MP]] | ||
| + | [[Category: Davies GJ]] | ||
| + | [[Category: Graham IA]] | ||
| + | [[Category: Li Y]] | ||
| + | [[Category: Offen WA]] | ||
| + | [[Category: Saleh P]] | ||
| + | [[Category: Winzer T]] | ||
Current revision
Papaver somniferum O-methyltransferase 1
| |||||||||||
Categories: Large Structures | Papaver somniferum | Cabry MP | Davies GJ | Graham IA | Li Y | Offen WA | Saleh P | Winzer T
