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8als
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8als is ON HOLD Authors: Pandian, R., Makumbe, H.H., Sayed, Y., Achilonu, I.A. Description: The apo-crystal structure of a variant form of the 28-k...) |
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The apo-crystal structure of a variant form of the 28-kDa Schistosoma haematobium glutathione transferase== |
| + | <StructureSection load='8als' size='340' side='right'caption='[[8als]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8als]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Schistosoma_haematobium Schistosoma haematobium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ALS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ALS FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8als FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8als OCA], [https://pdbe.org/8als PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8als RCSB], [https://www.ebi.ac.uk/pdbsum/8als PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8als ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GST28_SCHHA GST28_SCHHA] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.<ref>PMID:12939136</ref> GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.<ref>PMID:12939136</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: Achilonu | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Schistosoma haematobium]] |
| + | [[Category: Achilonu IA]] | ||
| + | [[Category: Makumbe HH]] | ||
| + | [[Category: Pandian R]] | ||
| + | [[Category: Sayed Y]] | ||
Current revision
The apo-crystal structure of a variant form of the 28-kDa Schistosoma haematobium glutathione transferase
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