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4etp

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{{STRUCTURE_4etp| PDB=4etp | SCENE= }}
 
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===C-terminal motor and motor homology domain of Kar3Vik1 fused to a synthetic heterodimeric coiled coil===
 
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{{ABSTRACT_PUBMED_22734002}}
 
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==Function==
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==C-terminal motor and motor homology domain of Kar3Vik1 fused to a synthetic heterodimeric coiled coil==
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[[http://www.uniprot.org/uniprot/KAR3_YEAST KAR3_YEAST]] Essential for yeast nuclear fusion during mating. KAR3 is a bifunctional protein having a kinesin-like motor domain joined to a distinct microtubule binding domain. It may mediate microtubule sliding during nuclear fusion and possibly mitosis. May interact with spindle microtubules to produce an inwardly directed force acting upon the poles. KAR3 function antagonizes CIP8 and KIP1 outward force action. KAR3 motor activity is directed toward the microtubule's minus end.<ref>PMID:2138512</ref> <ref>PMID:11729143</ref> [[http://www.uniprot.org/uniprot/VIK1_YEAST VIK1_YEAST]] Targets and/or maintains KAR3 at the spindle pole body during vegetative growth.<ref>PMID:10087265</ref> <ref>PMID:11729143</ref>
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<StructureSection load='4etp' size='340' side='right'caption='[[4etp]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4etp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ETP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ETP FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=EBC:N,N-ETHANE-1,2-DIYLBIS(2-IODOACETAMIDE)'>EBC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4etp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4etp OCA], [https://pdbe.org/4etp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4etp RCSB], [https://www.ebi.ac.uk/pdbsum/4etp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4etp ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KAR3_YEAST KAR3_YEAST] Essential for yeast nuclear fusion during mating. KAR3 is a bifunctional protein having a kinesin-like motor domain joined to a distinct microtubule binding domain. It may mediate microtubule sliding during nuclear fusion and possibly mitosis. May interact with spindle microtubules to produce an inwardly directed force acting upon the poles. KAR3 function antagonizes CIP8 and KIP1 outward force action. KAR3 motor activity is directed toward the microtubule's minus end.<ref>PMID:2138512</ref> <ref>PMID:11729143</ref>
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==About this Structure==
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==See Also==
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[[4etp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ETP OCA].
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*[[Kinesin 3D Structures|Kinesin 3D Structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:022734002</ref><references group="xtra"/><references/>
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__TOC__
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[[Category: Saccharomyces cerevisiae s288c]]
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</StructureSection>
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[[Category: Chen, C J.]]
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[[Category: Large Structures]]
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[[Category: Cope, J.]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Gilbert, S P.]]
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[[Category: Chen CJ]]
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[[Category: Hoenger, A.]]
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[[Category: Cope J]]
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[[Category: Porche, K.]]
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[[Category: Gilbert SP]]
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[[Category: Rank, K C.]]
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[[Category: Hoenger A]]
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[[Category: Rayment, I.]]
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[[Category: Porche K]]
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[[Category: Internal vik1 crosslink with n]]
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[[Category: Rank KC]]
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[[Category: Karyogamy]]
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[[Category: Rayment I]]
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[[Category: Kinesin motor homology domain]]
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[[Category: Kinesin motor protein]]
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[[Category: Microtubule]]
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[[Category: Mitosis]]
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[[Category: Motor protein]]
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[[Category: Nucleus]]
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Current revision

C-terminal motor and motor homology domain of Kar3Vik1 fused to a synthetic heterodimeric coiled coil

PDB ID 4etp

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