7zzv

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'''Unreleased structure'''
 
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The entry 7zzv is ON HOLD
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==Prostatic acid phosphatase (PAP) fragment (85-120)==
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<StructureSection load='7zzv' size='340' side='right'caption='[[7zzv]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7zzv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZZV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZZV FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zzv OCA], [https://pdbe.org/7zzv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zzv RCSB], [https://www.ebi.ac.uk/pdbsum/7zzv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zzv ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PPAP_HUMAN PPAP_HUMAN] A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.<ref>PMID:15280042</ref> <ref>PMID:18083097</ref> <ref>PMID:19403677</ref> <ref>PMID:20498373</ref> Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling.<ref>PMID:15280042</ref> <ref>PMID:18083097</ref> <ref>PMID:19403677</ref> <ref>PMID:20498373</ref>
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Authors: Blokhin, D.S., Yulmetov, A.R., Kusova, A.M., Skvortsova, P.V.
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==See Also==
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*[[Acid phosphatase 3D structures|Acid phosphatase 3D structures]]
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Description: Prostatic acid phosphatase (PAP) fragment (85-120)
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*[[Histone deacetylase 3D structures|Histone deacetylase 3D structures]]
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[[Category: Unreleased Structures]]
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== References ==
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[[Category: Skvortsova, P.V]]
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<references/>
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[[Category: Yulmetov, A.R]]
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__TOC__
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[[Category: Kusova, A.M]]
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</StructureSection>
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[[Category: Blokhin, D.S]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Blokhin DS]]
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[[Category: Kusova AM]]
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[[Category: Skvortsova PV]]
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[[Category: Yulmetov AR]]

Current revision

Prostatic acid phosphatase (PAP) fragment (85-120)

PDB ID 7zzv

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