Ras GTPase activating protein

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[[Image:2gqi.png|left|thumb|300px|NMR Structure of the Ras GTPase activating protein, [[2gqi]]]]
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<StructureSection load='2j05' size='350' side='right' caption='Human Ras GTPase activating protein dimer SH3 domain (PDB code [[2j05]]).' scene=''>
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{{STRUCTURE_2j05| right| PDB=2j05 | SCENE=|CAPTION= Human Ras GTPase activating protein dimer. SH3 domain, [[2j05]] }}
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== Function ==
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[[Ras GTPase activating protein]] (RasGAP) inactivates Ras from its active GTP-bound form to its GDP-bound form<ref>PMID:9113414</ref>. It is part of the mitogenic signal transmission via its N-terminal SH2-SH3-SH2 domains. <br/>
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'''SynGAP''' is a neuronal RasGAP expressed in brain and negatively regulates Ras activity and its signaling pathways<ref>PMID:12598599</ref>.
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== Relevance ==
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Inactivated RasGAP activate RAS which is mutated in 30% of cancer types<ref>PMID:24814062</ref>. RasGAP Colra1 is involved in infection-related morphogenesis in gourd family plants<ref>PMID:25275394</ref>.
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</StructureSection>
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== 3D Structures of Ras GTPase activating protein ==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*RasGAP 1
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**[[2gqi]] – hRasGAP SH3 domain 281-341 – human – NMR<br />
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**[[2j05]], [[2j06]], [[4fss]] - hRasGAP SH3 domain<br />
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**[[2m51]] – hRasGAP SH3 domain 58-118 + DLC1 RhoGAP domain 671-880<br />
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**[[2gsb]], [[6wax]] - hRasGAP C-terminal SH2 domain 341-446 – NMR<br />
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**[[6pxb]] - hRasGAP N-terminal SH2 domain 174-280<br />
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**[[6pxc]] - hRasGAP N-terminal SH2 domain + RhoGAP peptide<br />
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**[[6way]] - hRasGAP C-terminal SH2 domain + RhoGAP peptide<br />
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**[[8dgq]] - hRasGAP 174-444 + RhoGAP peptide<br />
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**[[6wax]] - hRasGAP C-terminal SH2 domain<br />
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**[[2gsb]] - hRasGAP SH2 domain – NMR<br />
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**[[1wer]] - hRasGAP catalytic domain 714-1047<br />
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**[[1wq1]] - hRasGAP catalytic domain + H-Ras<br />
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*RasGAP SynGAP
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**[[3bxj]] - SynGAP C2-GAP fragment - rat<br />
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**[[5jxc]] - SynGAP coiled-coil domain - mouse<br />
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}}
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== References ==
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[[Ras GTPase activating protein]] (RasGAP) inactivates Ras from its active GTP-bound form to its GDP-bound form. It is part of the mitogenic signal transmission via its N-terminal SH2-SH3-SH2 domains. The images on the left and right correspond to one representative RasGAP structure, ''i.e.'' the human RasGAP SH3 domain ([[2gqi]]).
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== 3D Structures of Ras GTPase activating protein ==
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[[2gqi]] – hRasGAP SH3 domain – human – NMR<br />
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[[2j05]], [[2j06]] - hRasGAP SH3 domain<br />
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[[2gsb]] - hRasGAP SH2 domain – NMR<br />
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[[3bxj]] - hRasGAP SYNGAP fragment - rat<br />
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[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Human Ras GTPase activating protein dimer SH3 domain (PDB code 2j05).

Drag the structure with the mouse to rotate

3D Structures of Ras GTPase activating protein

Updated on 04-August-2024

References

  1. ↑ Tocque B, Delumeau I, Parker F, Maurier F, Multon MC, Schweighoffer F. Ras-GTPase activating protein (GAP): a putative effector for Ras. Cell Signal. 1997 Feb;9(2):153-8. PMID:9113414
  2. ↑ Kim JH, Lee HK, Takamiya K, Huganir RL. The role of synaptic GTPase-activating protein in neuronal development and synaptic plasticity. J Neurosci. 2003 Feb 15;23(4):1119-24. PMID:12598599 doi:10.1523/JNEUROSCI.23-04-01119.2003
  3. ↑ Maertens O, Cichowski K. An expanding role for RAS GTPase activating proteins (RAS GAPs) in cancer. Adv Biol Regul. 2014 May;55:1-14. doi: 10.1016/j.jbior.2014.04.002. Epub 2014 Apr, 30. PMID:24814062 doi:http://dx.doi.org/10.1016/j.jbior.2014.04.002
  4. ↑ Harata K, Kubo Y. Ras GTPase activating protein CoIra1 is involved in infection-related morphogenesis by regulating cAMP and MAPK signaling pathways through CoRas2 in Colletotrichum orbiculare. PLoS One. 2014 Oct 2;9(9):e109045. doi: 10.1371/journal.pone.0109045. eCollection, 2014. PMID:25275394 doi:http://dx.doi.org/10.1371/journal.pone.0109045

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Michal Harel, Alexander Berchansky

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