Thioredoxin Reductase
From Proteopedia
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| - | <StructureSection load=' | + | <StructureSection load='' size='350' side='right' caption='Human Thioredoxin reductase dimer (cyan, green) complex with thioredoxin (yellow, pink), glycerol and FAD (PDB entry [[3qfa]])' scene='43/433123/Cv/2'> |
== Function == | == Function == | ||
| - | [[Thioredoxin Reductase]] (TrxR) is an enzyme which reduces thioredoxin using NADPH<ref>PMID:11012661</ref>. '''TrxR-2''' is mitochondrial. | + | [[Thioredoxin Reductase]] or '''glutaredoxin domain-containing protein''' (TrxR) is an enzyme which reduces thioredoxin using NADPH<ref>PMID:11012661</ref>. '''TrxR-1''' is cystolic while '''TrxR-2''' is mitochondrial. '''TrxR-3''' is highly expressed in testis. For more details see: |
| + | *[[User:Sarah Abdalla/Thioredoxin Reductase]] | ||
| + | *[[Glucocorticoids]] | ||
| + | *[[Steroid Hormones and their receptors]] | ||
== Disease == | == Disease == | ||
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== Structural highlights == | == Structural highlights == | ||
| - | TrxR and Trx form an intramolecular Cys-Cys bond<ref>PMID:21750537</ref>. | + | TrxR and Trx form an <scene name='43/433123/Cv/6'>intramolecular Cys-Cys bond</scene><ref>PMID:21750537</ref>. <scene name='43/433123/Cv/7'>FAD binding site</scene>. Water molecules are shown as red spheres. |
| + | == 3D Structures of Thioredoxin Reductase == | ||
| + | [[Thioredoxin reductase 3D structures]] | ||
</StructureSection> | </StructureSection> | ||
| - | == 3D Structures of Thioredoxin Reductase == | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *Thioredoxin reductase | ||
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| - | **[[1cl0]], [[1tde]], [[1trb]], [[4o5q]], [[4o5u]] – EcTrxR+FAD – ''Eschericia coli''<br /> | ||
| - | **[[1tdf]] - EcTrxR+FAD+NADPH<br /> | ||
| - | **[[1f6m]] - EcTrxR (mutant)+Trx-1+FAD+AADPH<br /> | ||
| - | **[[1h6v]] – rTrxR (mutant)+FAD+NADPH – rat<br /> | ||
| - | **[[1vdc]] – TrxR+FAD – ''Arabidopsis thaliana''<br /> | ||
| - | **[[2a87]] - MtTrxR+FAD+NADPH – ''Mycobacterium tuberculosis''<br /> | ||
| - | **[[5c04]], [[5id2]], [[4x0x]], [[4x1u]] – MtTrxR <br /> | ||
| - | **[[3cty]] - TrxR+FAD – ''Thermoplasma acidophilum''<br /> | ||
| - | **[[2zbw]] – TrxR + FAD – ''Thermus thermophilus''<br /> | ||
| - | **[[5j60]] – TrxR + FAD – ''Gloeobacter violaceus''<br /> | ||
| - | **[[3d8x]] - yTrxR+FAD+NADPH - yeast<br /> | ||
| - | **[[2nvk]] - DmTrxR+FAD+NADPH – ''Drosophila melanogaster''<br /> | ||
| - | **[[2q0k]], [[2q0l]] - HpTrxR+FAD+NADPH – ''Helicobacter pylori''<br /> | ||
| - | **[[3ish]] - HpTrxR+FAD<br /> | ||
| - | **[[2q7v]] - TrxR+FAD – ''Deinococcus radiodurans''<br /> | ||
| - | **[[3r9u]] – TrxR – ''Campylobacter jejuni''<br /> | ||
| - | **[[4a5l]], [[4up3]], [[4cbq]] - EhTrxR+FAD+NADPH – ''Entamoeba histolytica''<br /> | ||
| - | **[[4a65]] - EhTrxR+FAD+NADPH + Au<br /> | ||
| - | **[[4ccq]] - EhTrxR+NADPH<br /> | ||
| - | **[[4ccr]] - EhTrxR<br /> | ||
| - | **[[4b1b]] - PfTrxR+FAD – ''Plasmodium falciparum''<br /> | ||
| - | **[[4gcm]] - TrxR+FAD+NADPH – ''Staphylococcus aureus''<br /> | ||
| - | **[[4jnq]] – TrxR + FDA – ''Brucella melitensis''<br /> | ||
| - | **[[4ntd]] – TrxR + FDA + glutathione – ''Steptomyces clavuligerus''<br /> | ||
| - | **[[4zn0]] – TrxR – ''Methanosarcina mazei''<br /> | ||
| - | **[[4xrd]], [[4xs1]], [[4xs4]], [[4xs6]], [[4xs8]], [[4xts]], [[4xra]] – TrxR (mutant) – ''Salmonella enterica''<br /> | ||
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| - | *Thioredoxin reductase 1 | ||
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| - | **[[2cfy]] – hTrxR-1+FAD – human<br /> | ||
| - | **[[2zz0]], [[2zzb]], [[2zzc]] – hTrxR-1 (mutant)+FAD<br /> | ||
| - | **[[2j3n]] – hTrxR-1+FAD+NADPH<br /> | ||
| - | **[[3qfa]], [[3qfb]] - hTrxR-1 (mutant) +FAD+ Trx<br /> | ||
| - | **[[3itj]] – yTrxR-1+FAD <br /> | ||
| - | **[[3dh9]], [[3dgh]] – DmTrxR-1+FAD<br /> | ||
| - | **[[4kpr]] - rTrxR-1 +FAD<br /> | ||
| - | **[[3ean]], [[3eao]] – rTrxR-1+FAD+NADPH | ||
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| - | *Thioredoxin reductase 2 | ||
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| - | **[[1zdl]], [[1zkq]] – mTrxR-2+FAD+NADPH – mouse<br /> | ||
| - | **[[3dgz]] – mTrxR-2+FAD<br /> | ||
| - | **[[2whd]] – TrxR-2+FAD – ''Hordeum vulgare''<br /> | ||
| - | **[[4j56]], [[4j57]] - PfTrxR-2 (mutant) + Trx (mutant) +FAD<br /> | ||
| - | **[[4owy]] – yTrxR-2 <br /> | ||
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| - | *Thioredoxin reductase 3 | ||
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| - | **[[3f8d]], [[3f8p]], [[3f8r]] – TrxR-3 (mutant)+FAD – ''Sulfolobus solfataricus''<br /> | ||
| - | **[[3h8q]] – hTrxR-3 glutaredoxin domain<br /> | ||
| - | **[[2lv3]] - mTrxR-3 glutaredoxin domain<br /> | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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References
- ↑ Arner ES, Holmgren A. Physiological functions of thioredoxin and thioredoxin reductase. Eur J Biochem. 2000 Oct;267(20):6102-9. PMID:11012661
- ↑ Prasad R, Chan LF, Hughes CR, Kaski JP, Kowalczyk JC, Savage MO, Peters CJ, Nathwani N, Clark AJ, Storr HL, Metherell LA. Thioredoxin Reductase 2 (TXNRD2) mutation associated with familial glucocorticoid deficiency (FGD). J Clin Endocrinol Metab. 2014 Aug;99(8):E1556-63. doi: 10.1210/jc.2013-3844. Epub, 2014 Mar 6. PMID:24601690 doi:http://dx.doi.org/10.1210/jc.2013-3844
- ↑ Fritz-Wolf K, Kehr S, Stumpf M, Rahlfs S, Becker K. Crystal structure of the human thioredoxin reductase-thioredoxin complex. Nat Commun. 2011 Jul 12;2:383. doi: 10.1038/ncomms1382. PMID:21750537 doi:10.1038/ncomms1382
