Thioredoxin Reductase
From Proteopedia
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<StructureSection load='' size='350' side='right' caption='Human Thioredoxin reductase dimer (cyan, green) complex with thioredoxin (yellow, pink), glycerol and FAD (PDB entry [[3qfa]])' scene='43/433123/Cv/2'> | <StructureSection load='' size='350' side='right' caption='Human Thioredoxin reductase dimer (cyan, green) complex with thioredoxin (yellow, pink), glycerol and FAD (PDB entry [[3qfa]])' scene='43/433123/Cv/2'> | ||
== Function == | == Function == | ||
| - | [[Thioredoxin Reductase]] or '''glutaredoxin domain-containing protein''' (TrxR) is an enzyme which reduces thioredoxin using NADPH<ref>PMID:11012661</ref>. '''TrxR-1''' is cystolic while '''TrxR-2''' is mitochondrial. For more details see: | + | [[Thioredoxin Reductase]] or '''glutaredoxin domain-containing protein''' (TrxR) is an enzyme which reduces thioredoxin using NADPH<ref>PMID:11012661</ref>. '''TrxR-1''' is cystolic while '''TrxR-2''' is mitochondrial. '''TrxR-3''' is highly expressed in testis. For more details see: |
*[[User:Sarah Abdalla/Thioredoxin Reductase]] | *[[User:Sarah Abdalla/Thioredoxin Reductase]] | ||
*[[Glucocorticoids]] | *[[Glucocorticoids]] | ||
Current revision
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References
- ↑ Arner ES, Holmgren A. Physiological functions of thioredoxin and thioredoxin reductase. Eur J Biochem. 2000 Oct;267(20):6102-9. PMID:11012661
- ↑ Prasad R, Chan LF, Hughes CR, Kaski JP, Kowalczyk JC, Savage MO, Peters CJ, Nathwani N, Clark AJ, Storr HL, Metherell LA. Thioredoxin Reductase 2 (TXNRD2) mutation associated with familial glucocorticoid deficiency (FGD). J Clin Endocrinol Metab. 2014 Aug;99(8):E1556-63. doi: 10.1210/jc.2013-3844. Epub, 2014 Mar 6. PMID:24601690 doi:http://dx.doi.org/10.1210/jc.2013-3844
- ↑ Fritz-Wolf K, Kehr S, Stumpf M, Rahlfs S, Becker K. Crystal structure of the human thioredoxin reductase-thioredoxin complex. Nat Commun. 2011 Jul 12;2:383. doi: 10.1038/ncomms1382. PMID:21750537 doi:10.1038/ncomms1382
