1cto

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(New page: 200px<br /><applet load="1cto" size="450" color="white" frame="true" align="right" spinBox="true" caption="1cto" /> '''NMR STRUCTURE OF THE C-TERMINAL DOMAIN OF TH...)
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[[Image:1cto.gif|left|200px]]<br /><applet load="1cto" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1cto" />
 
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'''NMR STRUCTURE OF THE C-TERMINAL DOMAIN OF THE LIGAND-BINDING REGION OF MURINE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR, MINIMIZED AVERAGE STRUCTURE'''<br />
 
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==Overview==
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==NMR STRUCTURE OF THE C-TERMINAL DOMAIN OF THE LIGAND-BINDING REGION OF MURINE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR, MINIMIZED AVERAGE STRUCTURE==
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We have determined the NMR structure of a ligand-binding domain of the, granulocyte colony-stimulating factor (G-CSF) receptor, containing the, highly conserved WSxWS motif. The domain consists of seven beta-strands, with the fibronectin type III-like topology seen in several cytokine, receptors. Comparisons between the spectra of the 15N-labelled domain with, and without G-CSF indicate that the major ligand-recognition site is on, the FG loop just upstream of the WSxWS sequence, and not on the BC loop, which is mainly used in the growth hormone system. The WSxWS residues are, suggested to contribute to ligand-recognition and to the protein, architecture of the G-CSF receptor.
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<StructureSection load='1cto' size='340' side='right'caption='[[1cto]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1cto]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CTO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CTO FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 1 model</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cto OCA], [https://pdbe.org/1cto PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cto RCSB], [https://www.ebi.ac.uk/pdbsum/1cto PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cto ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CSF3R_MOUSE CSF3R_MOUSE] Receptor for granulocyte colony-stimulating factor (CSF3). In addition it may function in some adhesion or recognition events at the cell surface.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ct/1cto_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cto ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We have determined the NMR structure of a ligand-binding domain of the granulocyte colony-stimulating factor (G-CSF) receptor, containing the highly conserved WSxWS motif. The domain consists of seven beta-strands with the fibronectin type III-like topology seen in several cytokine receptors. Comparisons between the spectra of the 15N-labelled domain with and without G-CSF indicate that the major ligand-recognition site is on the FG loop just upstream of the WSxWS sequence, and not on the BC loop which is mainly used in the growth hormone system. The WSxWS residues are suggested to contribute to ligand-recognition and to the protein architecture of the G-CSF receptor.
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==About this Structure==
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Solution structure of an extracellular domain containing the WSxWS motif of the granulocyte colony-stimulating factor receptor and its interaction with ligand.,Yamasaki K, Naito S, Anaguchi H, Ohkubo T, Ota Y Nat Struct Biol. 1997 Jun;4(6):498-504. PMID:9187659<ref>PMID:9187659</ref>
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1CTO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1CTO OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Solution structure of an extracellular domain containing the WSxWS motif of the granulocyte colony-stimulating factor receptor and its interaction with ligand., Yamasaki K, Naito S, Anaguchi H, Ohkubo T, Ota Y, Nat Struct Biol. 1997 Jun;4(6):498-504. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9187659 9187659]
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</div>
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[[Category: Mus musculus]]
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<div class="pdbe-citations 1cto" style="background-color:#fffaf0;"></div>
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[[Category: Single protein]]
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[[Category: Anaguchi, H.]]
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[[Category: Naito, S.]]
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[[Category: Ohkubo, T.]]
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[[Category: Ota, Y.]]
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[[Category: Yamasaki, K.]]
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[[Category: binding protein]]
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[[Category: cytokine receptor]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 12:45:07 2007''
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==See Also==
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*[[Colony-stimulating factor 3D structures|Colony-stimulating factor 3D structures]]
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*[[Colony-stimulating factor receptor 3D structures|Colony-stimulating factor receptor 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Anaguchi H]]
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[[Category: Naito S]]
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[[Category: Ohkubo T]]
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[[Category: Ota Y]]
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[[Category: Yamasaki K]]

Current revision

NMR STRUCTURE OF THE C-TERMINAL DOMAIN OF THE LIGAND-BINDING REGION OF MURINE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR, MINIMIZED AVERAGE STRUCTURE

PDB ID 1cto

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