Pseudouridine synthase
From Proteopedia
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(New page: {{STRUCTURE_1k8w| PDB=1k8w | SIZE=400| SCENE= |right|CAPTION=E. coli tRNA pseudouridine synthase complex with stem-loop RNA 1k8w }} '''tRNA pseudouridine synthase''' (PUS) catalyz...) |
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| + | <StructureSection load='1ze2' size='400' side='right' caption='tRNA pseudouridine synthase complex with RNA that contains pseudouridine monophosphate [[1ze2]]' scene='46/465439/Cv/1' pspeed='8'> | ||
| + | __TOC__ | ||
| + | ==Function== | ||
| + | [[Pseudouridine]] is an abundant modified nucleoside found in RNA molecules. It is formed post-transcriptionally in RNA molecules by isomerization of the bond between base and ribose in uridine. There are two major types of enzymes that catalyze this reaction: | ||
| - | + | * [[RNA-guided pseudouridine synthase]] -- Some ribonucleoproteins (complexes of proteins and small RNAs) have been identified in archaea and eukaryotes to catalyze these reactions. The small RNA in the complex serves as a guide element to select the site of modification through base-pairing with the target RNA molecule. | |
| - | + | * [[Guide-independent Pseudouridine synthase|Guide-independent pseudouridine synthase]] -- The alternative to using the RNA-guided mechanism for pseudouridine formation is a [[Guide-independent Pseudouridine synthase|guide-independent mechanism]] acting through protein-only enzymes to catalyze the isomerization. | |
| - | + | == Structural highlights == | |
| + | The conversion of uridine to pseudouridine is accompanied by a conformational change of pseudouridine synthase<ref>PMID:14990747</ref>. <scene name='46/465439/Cv/4'>tRNA pseudouridine synthase binding with pseudouridine monophosphate</scene> ([[1ze2]]). | ||
| + | == 3D Structures of pseudouridine synthase == | ||
| + | [[Pseudouridine synthase 3D structures]] | ||
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| + | </StructureSection> | ||
| - | == 3D Structures of tRNA pseudouridine synthase== | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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Michal Harel, Angel Herraez, Alexander Berchansky, Jaime Prilusky, Wayne Decatur
