Pseudouridine synthase

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{{STRUCTURE_1k8w| PDB=1k8w | SIZE=400| SCENE= |right|CAPTION=E. coli tRNA pseudouridine synthase complex with stem-loop RNA, pseudouridine monophosphate and sulfate [[1k8w]] }}
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<StructureSection load='1ze2' size='400' side='right' caption='tRNA pseudouridine synthase complex with RNA that contains pseudouridine monophosphate [[1ze2]]' scene='46/465439/Cv/1' pspeed='8'>
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__TOC__
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==Function==
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[[Pseudouridine]] is an abundant modified nucleoside found in RNA molecules. It is formed post-transcriptionally in RNA molecules by isomerization of the bond between base and ribose in uridine. There are two major types of enzymes that catalyze this reaction:
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'''tRNA pseudouridine synthase''' (PUS) catalyzes the conversion of tRNA uridine to tRNA pseudouridine. PUS are active in the ribosomal large subunit (Rlu) and ribosomal small subunit (Rsu).
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* [[RNA-guided pseudouridine synthase]] -- Some ribonucleoproteins (complexes of proteins and small RNAs) have been identified in archaea and eukaryotes to catalyze these reactions. The small RNA in the complex serves as a guide element to select the site of modification through base-pairing with the target RNA molecule.
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* [[Guide-independent Pseudouridine synthase|Guide-independent pseudouridine synthase]] -- The alternative to using the RNA-guided mechanism for pseudouridine formation is a [[Guide-independent Pseudouridine synthase|guide-independent mechanism]] acting through protein-only enzymes to catalyze the isomerization.
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== Structural highlights ==
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The conversion of uridine to pseudouridine is accompanied by a conformational change of pseudouridine synthase<ref>PMID:14990747</ref>. <scene name='46/465439/Cv/4'>tRNA pseudouridine synthase binding with pseudouridine monophosphate</scene> ([[1ze2]]).
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== 3D Structures of pseudouridine synthase ==
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[[Pseudouridine synthase 3D structures]]
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</StructureSection>
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== 3D Structures of tRNA pseudouridine synthase==
 
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

tRNA pseudouridine synthase complex with RNA that contains pseudouridine monophosphate 1ze2

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