3qmk

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[[Image:3qmk.png|left|200px]]
 
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==Crystal structure of the E2 domain of APLP1 in complex with heparin hexasaccharide==
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The line below this paragraph, containing "STRUCTURE_3qmk", creates the "Structure Box" on the page.
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<StructureSection load='3qmk' size='340' side='right'caption='[[3qmk]], [[Resolution|resolution]] 2.21&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3qmk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QMK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QMK FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.21&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IDS:2-O-SULFO-ALPHA-L-IDOPYRANURONIC+ACID'>IDS</scene>, <scene name='pdbligand=SGN:N,O6-DISULFO-GLUCOSAMINE'>SGN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3qmk| PDB=3qmk | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qmk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qmk OCA], [https://pdbe.org/3qmk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qmk RCSB], [https://www.ebi.ac.uk/pdbsum/3qmk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qmk ProSAT]</span></td></tr>
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</table>
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===Crystal structure of the E2 domain of APLP1 in complex with heparin hexasaccharide===
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== Function ==
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[https://www.uniprot.org/uniprot/APLP1_HUMAN APLP1_HUMAN] May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I. The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis.
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__TOC__
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 21930949 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21930949}}
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==About this Structure==
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[[3qmk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QMK OCA].
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==Reference==
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<ref group="xtra">PMID:021930949</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ha, Y.]]
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[[Category: Large Structures]]
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[[Category: Xue, Y.]]
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[[Category: Ha Y]]
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[[Category: Alzheimer's disease]]
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[[Category: Xue Y]]
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[[Category: App]]
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[[Category: Brain]]
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[[Category: Cell adhesion]]
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[[Category: Cellular adhesion]]
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[[Category: Heparin]]
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Current revision

Crystal structure of the E2 domain of APLP1 in complex with heparin hexasaccharide

PDB ID 3qmk

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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