4g69

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[[Image:4g69.jpg|left|200px]]
 
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{{STRUCTURE_4g69| PDB=4g69 | SCENE= }}
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==Structure of the Human Discs Large 1 PDZ2 - Adenomatous Polyposis Coli Cytoskeletal Polarity Complex==
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<StructureSection load='4g69' size='340' side='right'caption='[[4g69]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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===Structure of the Human Discs Large 1 PDZ2 - Adenomatous Polyposis Coli Cytoskeletal Polarity Complex===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4g69]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G69 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G69 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_23185543}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g69 OCA], [https://pdbe.org/4g69 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g69 RCSB], [https://www.ebi.ac.uk/pdbsum/4g69 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g69 ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[4g69]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G69 OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/DLG1_HUMAN DLG1_HUMAN] Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel.<ref>PMID:10656683</ref> <ref>PMID:12445884</ref> <ref>PMID:14699157</ref> <ref>PMID:15263016</ref> <ref>PMID:19213956</ref> <ref>PMID:20605917</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Slep, K C.]]
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[[Category: Large Structures]]
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[[Category: Adenomatous polyposis coli]]
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[[Category: Slep KC]]
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[[Category: Adherens junction]]
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[[Category: Maguk]]
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[[Category: Membrane protein-signaling protein complex]]
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[[Category: Pdz]]
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[[Category: Polarity]]
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[[Category: Tetramethylrhodamine]]
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Current revision

Structure of the Human Discs Large 1 PDZ2 - Adenomatous Polyposis Coli Cytoskeletal Polarity Complex

PDB ID 4g69

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