2jxx

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[[Image:2jxx.png|left|200px]]
 
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{{STRUCTURE_2jxx| PDB=2jxx | SCENE= }}
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==NMR solution structure of Ubiquitin-like domain of NFATC2IP. Northeast Structural Genomics Consortium target HR5627==
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<StructureSection load='2jxx' size='340' side='right'caption='[[2jxx]]' scene=''>
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===NMR solution structure of Ubiquitin-like domain of NFATC2IP. Northeast Structural Genomics Consortium target HR5627===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2jxx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JXX FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxx OCA], [https://pdbe.org/2jxx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jxx RCSB], [https://www.ebi.ac.uk/pdbsum/2jxx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jxx ProSAT], [https://www.topsan.org/Proteins/NESGC/2jxx TOPSAN]</span></td></tr>
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[[2jxx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXX OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NF2IP_HUMAN NF2IP_HUMAN] In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jx/2jxx_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jxx ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Butler, C.]]
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[[Category: Arrowsmith CH]]
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[[Category: Dhe-Paganon, S.]]
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[[Category: Butler C]]
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[[Category: Doherty, R S.]]
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[[Category: Dhe-Paganon S]]
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[[Category: Edwards, A M.]]
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[[Category: Doherty RS]]
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[[Category: Fares, C.]]
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[[Category: Edwards AM]]
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[[Category: Karra, M.]]
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[[Category: Fares C]]
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[[Category: Lemak, A.]]
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[[Category: Karra M]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Lemak A]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Srisailam S]]
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[[Category: Srisailam, S.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: Yee A]]
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[[Category: Yee, A.]]
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[[Category: Cytoplasmic 2-interacting protein]]
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[[Category: Methylation]]
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[[Category: Nesg]]
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[[Category: Nfat complex]]
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[[Category: Northeast structural genomics consortium]]
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[[Category: Nuclear factor of activated t-cell]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Protein binding]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-2]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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[[Category: Ubiquitin like homologue]]
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Current revision

NMR solution structure of Ubiquitin-like domain of NFATC2IP. Northeast Structural Genomics Consortium target HR5627

PDB ID 2jxx

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