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| - | [[Image:RPS5.png|left|200px|thumb|Crystal Structure of Ribosomal protein S5 from [[2zm6]], chain E]]
| + | <StructureSection load='1pkp' size='350' side='right' caption='Structure of bacterial ribosomal protein S5 (PDB entry [[1pkp]])' scene=''> |
| - | {{STRUCTURE_2zm6| PDB=2zm6 | SIZE=400| SCENE=Ribosomal_protein_S5/Cv/1 |right|CAPTION=Ribosomal protein S5 from [[2zm6]], chain E }}
| + | == Function == |
| - | | + | '''Ribosomal protein S5''' (RPS5) is one of the 21 proteins which belong to the 30S <scene name='Ribosomal_protein_S5/Cv/2'>small subunit</scene> of the [http://en.wikipedia.org/wiki/Bacteria bacterial] [[ribosome]] or the 30 proteins which belong to the 40S small subunit of the eukaryotic ribosome<ref>PMID:1508272</ref>. |
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| - | '''Ribosomal protein S5''' (RPS5) is one of the 22 proteins which belong to the <scene name='Ribosomal_protein_S5/Cv/2'>small subunit</scene> of the [http://en.wikipedia.org/wiki/Bacteria bacterial] [[ribosome]]. The images at the left and at the right correspond to one representative RPS5, ''i.e.'' the crystal structure of Ribosomal protein S5 from ''Thermus thermophilus'' ([[2zm6]], chain E). | + | |
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| - | {{TOC limit|limit=2}}
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| - | <br /> | + | |
| - | <br /> | + | |
| - | <br />
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| | + | == Relevance == |
| | + | RPS5 inhibitor exhibits potent inhibitory effect against liver fibrosis<ref>PMID:24668691</ref>. |
| | == 3D Structures of Ribosomal protein S5 == | | == 3D Structures of Ribosomal protein S5 == |
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| | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} |
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| - | ===S5 in small ribosomal subunit=== | + | ===Ribosomal protein S5 in part of small ribosomal subunit=== |
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| - | [[2zm6]], [[1n36]], [[1j5e]], [[3oge]], [[3ogy]], [[3ohc]], [[3ohd]], [[3ohy]], [[3oi0]], [[3oi2]], [[3oi4]], [[3oto]] - TtRPS5 in 30S ribosomal subunit+THX+16S RRNA – ''Thermus thermophilus''<br /> | + | [[1qd7]] – TtRPS5+TtRPS4+TtRPS6+TtRPS7+TtRPS8+TtRPS15+TtRPS17+TtRPS20+16S RRNA fragment - ''Thermus thermophilus''<br /> |
| - | [[2vqe]], [[2vqf]], [[2uuc]], [[2e5l]], [[2uu9]], [[2uua]], [[2uub]], [[3pyn]], [[3pyq]], [[3pys]], [[3pyu]] - TtRPS5 in 30S ribosomal subunit+16S RRNA+RNA fragment<br />
| + | [[1dv4]] – TtRPS5+ TtRPS7+16S RRNA fragment <br /> |
| - | [[3kc4]] – EcRPS5 in 30S ribosomal subunit - ''Escherichia coli''<br />
| + | |
| - | [[3i1m]], [[3i1o]], [[3df1]], [[3df3]], [[2vho]], [[2vhp]], [[2avy]], [[2aw7]], [[1pnx]], [[3oaq]], [[3oar]], [[3ofa]], [[3ofb]], [[3ofo]], [[3ofp]], [[3ofx]], [[3ofy]], [[3or9]], [[3ora]] - EcRPS5 in 30S ribosomal subunit+16S RRNA<br />
| + | |
| - | [[1i94]], [[1fka]], [[3uxs]], [[3uxt]], [[4dr1]] - TtRPS5 in 30S ribosomal subunit+16S RRNA<br />
| + | |
| - | [[4dr4]] – TtRPS5 in 30S ribosomal subunit+16S RRNA + mRNA<br />
| + | |
| - | [[1p87]], [[1p6g]] - EcRPS5 in 30S ribosomal subunit+16S RRNA – Cryo-EM<br />
| + | |
| - | [[3bbn]] - RPS5 in 30S ribosomal subunit+16S RRNA – Cryo-EM – spinach
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| - | | + | |
| - | ===S5 in small + large ribosomal subunit===
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| - | [[1ml5]] - EcRPS5 in 30S ribosomal subunit+50S ribosomal subunit+THX+chain release factor 2+P-site tRNA+tRNA Phe+mRNA fragment+23S RRNA+5S RRNA+16S RRNA - EM<br />
| + | |
| - | [[3j0l]], [[3j0o]] - RPS5 in 40S ribosomal subunit+60S ribosomal subunit +tRNA +mRNA fragment+ RRNA fragments – rabbit - Cryo-EM
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| - | | + | |
| - | ===S5 in small ribosomal subunit+ chain release factor===
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| - | [[3mr8]], [[3ms0]] – TtRPS5 in 30S ribosomal subunit+THX+chain release factor 1+P-site tRNA+mRNA+16S RRNA <br />
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| - | [[3d5a]], [[3d5c]] - TtRPS5 in 30S ribosomal subunit+THX+chain release factor 1+P-site tRNA+E-site tRNA+mRNA +16S RRNA<br />
| + | |
| - | [[3zvo]] – TtRPS4 in 30S ribosomal subunit+THX+P-site tRNA Met +mRNA +16S RRNA+chain release factor 3<br />
| + | |
| - | [[2b64]] - TtRPS5 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA Phe+mRNA +16S RRNA+chain release factor 1<br />
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| - | [[2b9m]] - TtRPS5 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA Phe+mRNA +16S RRNA+chain release factor 2<br />
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| - | [[2x9r]], [[2x9t]], [[2wh1]], [[2wh3]] - TtRPS5 in 30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+mRNA +16S RRNA<br />
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| - | [[3f1e]], [[3f1g]] - TtRPS5 in 30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+E-site tRNA +16S RRNA<br />
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| - | [[3uoq]] - EcRPS5 + 16S RRNA + mRNA + peptide chain release factor<br />
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| - | | + | |
| - | ===S5 in small ribosomal subunit+tRNA+mRNA===
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| - | [[2hgi]] - TtRPS5 in 30S ribosomal subunit+16S RRNA+tRNA Phe+tRNA fMet<br />
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| - | [[2hgp]] - TtRPS5 in 30S ribosomal subunit+16S RRNA+tRNA Phe+mRNA<br />
| + | |
| - | [[3t1h]], [[3t1y]] - TtRPS5 in 30S ribosomal subunit+16S RRNA+tRNA Lys +mRNA<br />
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| - | [[3tvf]], [[3tvg]], [[3uyd]], [[3uyf]] - TtRPS5 in 30S ribosomal subunit+16S RRNA+tRNA Leu + tRNA fMet + mRNA<br />
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| - | [[3uz6]], [[3uz7]], [[3uzg]], [[3uzi]] - TtRPS5 in 30S ribosomal subunit+16S RRNA+tRNA Tyr + tRNA fMet + mRNA<br />
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| - | [[2i2p]], [[2i2u]] - EcRPS5 in 30S ribosomal subunit+16S RRNA+tRNA Phe+mRNA<br />
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| - | [[2hgr]] - TtRPS5 in 30S ribosomal subunit+16S RRNA+tRNA Phe+tRNA fMet+mRNA<br />
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| - | [[1yl4]] – TtRPS5 in 30S ribosomal subunit+ tRNA Phe+16S RRNA+THRS mRNA operator<br />
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| - | [[1pns]] - EcRPS5 in 30S ribosomal subunit+ tRNA Phe+16S RRNA+mRNA <br />
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| - | [[3j0u]], [[3j0v]], [[3j0x]], [[3j0z]], [[3j10]], [[3j20]] – EcRPS5 in 30S ribosomal subunit+ A-site tRNA + P-site tRNA +16S RRNA+mRNA – Cryo-EM<br />
| + | |
| - | [[3j13]] – EcRPS5 in 30S ribosomal subunit+ P-site tRNA +16S RRNA+mRNA – Cryo-EM<br />
| + | |
| - | [[1xnq]], [[1xnr]] - TtRPS5 in 30S ribosomal subunit+THX+mRNA+tRNA anticodon+16S RRNA
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| - | | + | |
| - | ===S5 in small ribosomal subunit+A-site tRNA===
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| - | | + | |
| - | [[2uxd]], [[2uxc]] - TtRPS5 in 30S ribosomal subunit+THX+A-site mRNA CGGG+tRNA anticodon+16S RRNA<br />
| + | |
| - | [[1n32]], [[1n33]] - TtRPS5 in 30S ribosomal subunit+THX+A-site mRNA fragment+tRNA anticodon+16S RRNA<br />
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| - | [[1n34]] - TtRPS5 in 30S ribosomal subunit+THX+A-site mRNA fragment +16S RRNA<br />
| + | |
| - | [[1xmo]], [[1xmq]] - TtRPS5 in 30S ribosomal subunit+THX+A-site mRNA+tRNA anticodon+16S RRNA<br />
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| - | [[2uxb]] - TtRPS5 in 30S ribosomal subunit+THX+A-site mRNA GGGU+tRNA anticodon+16S RRNA
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| - | | + | |
| - | ===S5 in small ribosomal subunit+P-site tRNA===
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| - | [[3i8g]] - TtRPS5 in 30S ribosomal subunit+P-site tRNA+mRNA +16S RRNA<br />
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| - | [[3i8h]], [[3i9b]], [[3i9d]] - TtRPS5 in 30S ribosomal subunit+THX+P-site tRNA+mRNA +16S RRNA<br />
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| - | [[1ibk]] - TtRPS5 in 30S ribosomal subunit+THX+P-site mRNA fragment +16S RRNA<br />
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| - | [[2wwl]] - EcRPS5 in 30S ribosomal subunit+Poly-Ala chain+P-site tRNA+mRNA +16S RRNA - ''Escherichia coli''<br />
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| - | [[3i1q]] - EcRPS5 in 30S ribosomal subunit+P-site tRNA hairpin+mRNA<br /> | + | |
| - | [[3i1s]], [[3i1z]], [[3i21]] - EcRPS5 in 30S ribosomal subunit+P-site tRNA hairpin+mRNA +16S RNA
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| - | | + | |
| - | ===S5 in small ribosomal subunit+A-site tRNA+P-site tRNA===
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| - |
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| - | [[1ibl]], [[1ibm]] - TtRPS5 in 30S ribosomal subunit+THX+A-site mRNA fragment+P-site mRNA fragment+tRNA anticodon+16S RRNA
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| - | | + | |
| - | ===S5 in small ribosomal subunit+P-site tRNA+E-site tRNA===
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| - | [[2ow8]] - TtRPS5 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA+mRNA +16S RRNA<br />
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| - | [[2b9o]] - TtRPS5 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA Phe+mRNA +16S RRNA<br />
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| - | [[2qnh]] - TtRPS5 in 30S ribosomal subunit+THX+P-site tRNA+E-site tRNA+mRNA +16S RRNA<br />
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| - | [[2wdg]], [[2wdh]], [[2wdk]], [[2wdm]] - TtRPS5 in 30S ribosomal subunit+THX+P-site tRNA+E-site tRNA+mRNA +16S RRNA+tRNA Phe
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| - | | + | |
| - | ===S5 in small ribosomal subunit+A-site tRNA+P-site tRNA+E-site tRNA===
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| - | [[2gy9]], [[2gyb]] - EcRPS5 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA – Cryo-EM<br />
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| - | [[1jgo]], [[1jgp]], [[1jgq]], [[1gix]] - TtRPS5 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+tRNA Phe+mRNA +16S RRNA<br />
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| - | [[3e1a]], [[3e1c]] - EcRPS5 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA
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| - | ===S5 in small ribosomal subunit + antibiotics===
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| - | [[1i95]], [[1i97]], [[2hhh]], [[2f4v]] , [[3knn]], [[4dr3]] - TtRPS5 in 30S ribosomal subunit+16S RRNA+antibiotic<br />
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| - | [[1hnw]], [[1hnx]], [[1hnz]], [[1fjg]], [[4aqy]], [[4dr5]], [[4dr6]], [[4dr7]] - TtRPS5 in 30S ribosomal subunit+16S RRNA+mRNA fragment+antibiotic<br />
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| - | [[2qbb]], [[2qb9]], [[1vs5]], [[1vs7]], [[2qan]], [[2qal]], [[2qou]], [[2qow]], [[2qoy]], [[2qp0]], [[2z4k]], [[2z4m]] - EcRPS5 in 30S ribosomal subunit+16S RRNA+antibiotic<br />
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| - | [[3sfs]] – EcRPS5 in 30S ribosomal subunit+16S RRNA+ mRNA + RF-3 + antibiotic<br />
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| - | [[4gaq]], [[4gas]] – EcRPS5 in 30S ribosomal subunit+16S RRNA+ mRNA + antibiotic<br />
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| - | [[2j00]], [[2j02]] - TtRPS5 in 30S ribosomal subunit+16S RRNA+paromomycin+P-site tRNA fMet+E-site tRNA Phe+mRNA<br />
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| - | [[3knj]], [[3knh]] - TtRPS5 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA+viomycin<br />
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| - | [[3knl]], [[3knm]] - TtRPS5 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA+capreomycin<br />
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| - | [[3uz3]], [[3uz4]] - TtRPS5 in 30S ribosomal subunit+16S RRNA+tRNA Leu + tRNA fMet + mRNA + paromomycin<br />
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| - | [[3uzl]], [[3uzm]] - TtRPS5 in 30S ribosomal subunit+16S RRNA+tRNA Tyr + tRNA fMet + mRNA + paromomycin
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| - | ===S5 in small ribosomal subunit + ribosome recycling factor===
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| - | [[2qbd]], [[2qbf]] - EcRPS5 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor<br />
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| - | [[3r8n]], [[3r8o]], [[4gd1]], [[4gd2]] – EcRPS5 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor + mRNA + tRNA<br />
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| - | [[2qbh]], [[2qbj]] - EcRPS5 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor+gentamicin<br />
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| - | [[2v46]], [[2v48]] - TtRPS5 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor+P-site tRNA Phe+mRNA+tRNA fMet
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| - | ===S5 in small ribosomal subunit + elongation factor===
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| - | [[2wri]], [[2wrk]], [[2xsy]], [[2xuy]] - TtRPS5 in 30S ribosomal subunit+THX+P-site tRNA+mRNA +16S RRNA+elongation factor G<br />
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| - | [[2wrn]], [[2wrq]] - TtRPS5 in 30S ribosomal subunit+THX+A-site tRNA+mRNA +16S RRNA+elongation factor TU-4<br />
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| - | [[2xqd]] - TtRPS5 in 30S ribosomal subunit+THX+E-site tRNA+mRNA +16S RRNA+elongation factor TU-B<br />
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| - | [[3fic]] - TtRPS5 in 30S ribosomal subunit+THX+A-site tRNA+P-site tRNA+E-site tRNA+mRNA codon+16S RRNA+elongation factor TU-A<br />
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| - | [[4abr]] - TtRPS5 in 30S ribosomal subunit+THX + E/P-site tRNA fMet +mRNA codon+16S RRNA+elongation factor TU<br />
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| - | [[3izv]] – EcRPS5 in 30S ribosomal subunit+A/T-site tRNA Phe +16S RRNA+elongation factor TU<br />
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| - | [[3j18]] - EcRPS5 in 30S ribosomal subunit+A/T-site tRNA Phe +16S RRNA+ mRNA + SSRA-binding protein + formyl-Met specific initiator tRNA + elongation factor G – Cryo-EM<br />
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| - | [[3izw]] – EcRPS5 in 30S ribosomal subunit+A-site tRNA Phe +mRNA +16S RRNA+elongation factor TU<br />
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| - | [[2y0u]], [[2y0w]], [[2y0y]], [[2y10]], [[2y12]], [[2y14]], [[2y16]], [[2y18]] - TtRPS5 in 30S subunit+THX+A-site tRNA+E-site tRNA+mRNA codon+16S RRNA+elongation factor TU<br />
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| - | [[3fih]] - EcRPS5 in 30S ribosomal subunit+A-site tRNA Phe+P-site tRNA+mRNA +16S RRNA+elongation factor TU<br />
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| - | [[3huw]], [[3huy]] - TtRPS5 in 30S ribosomal subunit+THX+tRNA-Met+mRNA +16S RRNA+elongation factor P<br />
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| - | [[1s1h]] - yRPS5 in 40S ribosomal subunit+18S RRNA+elongation factor 2 – Cryo-EM – yeast
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| - | ===S5 in small ribosomal subunit + translation initiation factor===
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| - | [[1i96]] - TtRPS5 in 30S ribosomal subunit+THX+IF3+16S RRNA<br />
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| - | [[1hr0]] - TtRPS5 in 30S ribosomal subunit+THX+IF+16S RRNA
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| - | ===S5 in small ribosomal subunit + various proteins===
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| - | [[3jyv]] – RPS5 in 40S ribosomal subunit+RACK1+S19E+P-site tRNA – ''Thermomyces lanuginosus''<br />
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| - | [[2xzm]], [[2xzn]] - RPS5 in 40S subunit+RACK1 - ''Tetrahymena thermophila''<br />
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| - | [[2zkq]] - RPS5 in 40S ribosomal subunit+RACK1+RNA – dog – Cryo EM<br />
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| - | [[3iz6]] - RPS5 in 40S ribosomal subunit+RACK1 – wheat – Cryo EM <br />
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| - | [[3kiq]], [[3kis]], [[3kiu]], [[3kix]] - TtRPS5 in 30S ribosomal subunit+toxin RelE+16S RRNA<br />
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| - | [[2xfz]], [[2xg1]] - TtRPS5 in 30S ribosomal subunit+colicin E3+E-site tRNA+mRNA+16S RRNA<br />
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| - | [[4dh9]], [[4dhb]] - TtRPS5 in 30S ribosomal subunit +16S RRNA+mRNA+P-site tRNA fMet +THX + YAEJ<br />
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| - | [[1voq]], [[1vos]], [[1vov]], [[1vox]], [[1voz]] - EcRPS5 in 30S ribosomal subunit+protein Y+16S RRNA<br />
| + | |
| - | [[2noq]] – yRPS5+yRPL1+18S RRNA+25S RRNA+CRPV IRES<br />
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| - | [[3o2z]], [[3o30]] - yRPS5 in 40S ribosomal subunit+18S RRNA+RACK1<br />
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| - | [[3izb]] - yRPS5 in 40S ribosomal subunit+ RACK1 – Cryo-EM<br />
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| - | [[3u5c]], [[3u5g]] - yRPS5 in 40S ribosomal subunit+ RACK1 + suppressor protein SMT1<br />
| + | |
| - | [[3iy8]] – EcRPS5+S6+S8+S9+S11+S12+S15+S16+S17+S18+''Leishmania taretolae'' small subunit<br />
| + | |
| - | [[3j00]] – EcRPS5 + 16S RRNA + FTSQ + apolipoprotein A-I<br />
| + | |
| - | [[2ykr]] – EcRPS5 + 16S RRNA + GMPPNP + GTPase RSGA<br />
| + | |
| - | [[4a2i]] – EcRPS5 + 16S RRNA + GTPase RSGA – Cryo EM<br />
| + | |
| - | [[4adv]] - EcRPS5 + 16S RRNA + methyltransferase – Cryo EM
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| - | | + | |
| - | ===S5 in part of small ribosomal subunit===
| + | |
| - | | + | |
| - | [[1qd7]] – TtRPS5+TtRPS4+TtRPS6+TtRPS7+TtRPS8+TtRPS15+TtRPS17+TtRPS20+16S RRNA fragment<br />
| + | |
| | [[1pkp]] – GsRPS5 – ''Geobacillus stearothermophilus''<br /> | | [[1pkp]] – GsRPS5 – ''Geobacillus stearothermophilus''<br /> |
| - | [[1dv4]] – GsRPS5+TtRPS7+16S RRNA | + | [[2noq]] – yRPS5+yRPL1+18S RRNA+25S RRNA+CRPV IRES – yeast<br /> |
| - | | + | == References == |
| | + | <references/> |
| | [[Category:Topic Page]] | | [[Category:Topic Page]] |
