3p0u

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{{STRUCTURE_3p0u| PDB=3p0u | SCENE= }}
 
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===Crystal Structure of the ligand binding domain of human testicular receptor 4===
 
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{{ABSTRACT_PUBMED_21068381}}
 
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==Function==
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==Crystal Structure of the ligand binding domain of human testicular receptor 4==
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[[http://www.uniprot.org/uniprot/NR2C2_HUMAN NR2C2_HUMAN]] Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear recptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation.<ref>PMID:7779113</ref> <ref>PMID:9556573</ref> <ref>PMID:10347174</ref> <ref>PMID:10644740</ref> <ref>PMID:17974920</ref>
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<StructureSection load='3p0u' size='340' side='right'caption='[[3p0u]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[3p0u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P0U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P0U FirstGlance]. <br>
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[[3p0u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P0U OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p0u OCA], [https://pdbe.org/3p0u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p0u RCSB], [https://www.ebi.ac.uk/pdbsum/3p0u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p0u ProSAT]</span></td></tr>
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==Reference==
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</table>
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<ref group="xtra">PMID:021068381</ref><references group="xtra"/><references/>
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== Function ==
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[https://www.uniprot.org/uniprot/NR2C2_HUMAN NR2C2_HUMAN] Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear recptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation.<ref>PMID:7779113</ref> <ref>PMID:9556573</ref> <ref>PMID:10347174</ref> <ref>PMID:10644740</ref> <ref>PMID:17974920</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chan, C W.]]
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[[Category: Large Structures]]
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[[Category: Engel, J D.]]
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[[Category: Chan C-W]]
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[[Category: Kruse, S W.]]
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[[Category: Engel JD]]
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[[Category: Reynolds, R.]]
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[[Category: Kruse SW]]
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[[Category: Suino-Powell, K M.]]
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[[Category: Reynolds R]]
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[[Category: Xu, H E.]]
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[[Category: Suino-Powell KM]]
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[[Category: Xu, Y.]]
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[[Category: Xu HE]]
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[[Category: Zhou, X E.]]
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[[Category: Xu Y]]
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[[Category: Ligand binding domain]]
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[[Category: Zhou XE]]
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[[Category: Orphan nuclear receptor]]
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[[Category: Signaling protein]]
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[[Category: Testicular receptor 4]]
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Current revision

Crystal Structure of the ligand binding domain of human testicular receptor 4

PDB ID 3p0u

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