4jbu

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{{STRUCTURE_4jbu| PDB=4jbu | SCENE= }}
 
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===1.65A structure of the T3SS tip protein LcrV (G28-D322, C273S) from Yersinia pestis===
 
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{{ABSTRACT_PUBMED_23695558}}
 
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==Function==
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==1.65A structure of the T3SS tip protein LcrV (G28-D322, C273S) from Yersinia pestis==
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[[http://www.uniprot.org/uniprot/LCRV_YERPE LCRV_YERPE]] Possibly involved in calcium regulation of YOP expression, which includes the export process.
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<StructureSection load='4jbu' size='340' side='right'caption='[[4jbu]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4jbu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JBU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JBU FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jbu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jbu OCA], [https://pdbe.org/4jbu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jbu RCSB], [https://www.ebi.ac.uk/pdbsum/4jbu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jbu ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LCRV_YERPE LCRV_YERPE] Possibly involved in calcium regulation of YOP expression, which includes the export process.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The human pathogen Yersinia pestis requires the assembly of the type III secretion system (T3SS) for virulence. The structural component of the T3SS contains an external needle and a tip complex, which is formed by LcrV in Y. pestis. The structure of an LcrV triple mutant (K40A/D41A/K42A) in a C273S background has previously been reported to 2.2 A resolution. Here, the crystal structure of LcrV without the triple mutation in a C273S background is reported at a higher resolution of 1.65 A. Overall the two structures are similar, but there are also notable differences, particularly near the site of the triple mutation. The refined structure revealed a slight shift in the backbone positions of residues Gly28-Asn43 and displayed electron density in the loop region consisting of residues Ile46-Val63, which was disordered in the original structure. In addition, the helical turn region spanning residues Tyr77-Gln95 adopts a different orientation.
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==About this Structure==
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Structure of the Yersinia pestis tip protein LcrV refined to 1.65 A resolution.,Chaudhury S, Battaile KP, Lovell S, Plano GV, De Guzman RN Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 May;69(Pt 5):477-81. doi: , 10.1107/S1744309113008579. Epub 2013 Apr 27. PMID:23695558<ref>PMID:23695558</ref>
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[[4jbu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JBU OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:023695558</ref><references group="xtra"/><references/>
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</div>
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<div class="pdbe-citations 4jbu" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Yersinia pestis]]
[[Category: Yersinia pestis]]
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[[Category: Battaile, K P.]]
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[[Category: Battaile KP]]
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[[Category: Chaudhury, S.]]
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[[Category: Chaudhury S]]
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[[Category: Guzman, R N.De.]]
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[[Category: De Guzman RN]]
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[[Category: Lovell, S.]]
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[[Category: Lovell S]]
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[[Category: Plano, G.]]
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[[Category: Plano G]]
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[[Category: Lcrv]]
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[[Category: Protein binding]]
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[[Category: T3ss]]
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[[Category: Tip protein]]
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[[Category: Yersinia pesti]]
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Current revision

1.65A structure of the T3SS tip protein LcrV (G28-D322, C273S) from Yersinia pestis

PDB ID 4jbu

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