3tj0

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==Crystal Structure of Influenza B Virus Nucleoprotein==
==Crystal Structure of Influenza B Virus Nucleoprotein==
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<StructureSection load='3tj0' size='340' side='right' caption='[[3tj0]], [[Resolution|resolution]] 3.23&Aring;' scene=''>
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<StructureSection load='3tj0' size='340' side='right'caption='[[3tj0]], [[Resolution|resolution]] 3.23&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3tj0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_b_virus Influenza b virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TJ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TJ0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3tj0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_B_virus_(B/Managua/4577.01/2008) Influenza B virus (B/Managua/4577.01/2008)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TJ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TJ0 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11520 Influenza B virus])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.233&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tj0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tj0 RCSB], [http://www.ebi.ac.uk/pdbsum/3tj0 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tj0 OCA], [https://pdbe.org/3tj0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tj0 RCSB], [https://www.ebi.ac.uk/pdbsum/3tj0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tj0 ProSAT]</span></td></tr>
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<table>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/C4LQ26_9INFB C4LQ26_9INFB] Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals and is responsible of the active RNP import into the nucleus through the cellular importin alpha/beta pathway. Later in the infection, nucleus export of RNP are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that the nucleoprotein binds directly exportin-1 (XPO1) and plays an active role in RNP nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmask nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus (By similarity).[SAAS:SAAS002141_004_603280]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Structural basis for RNA binding and homo-oligomer formation by influenza B virus nucleoprotein.,Ng AK, Lam MK, Zhang H, Liu J, Au SW, Chan PK, Wang J, Shaw PC J Virol. 2012 Jun;86(12):6758-67. Epub 2012 Apr 11. PMID:22496219<ref>PMID:22496219</ref>
Structural basis for RNA binding and homo-oligomer formation by influenza B virus nucleoprotein.,Ng AK, Lam MK, Zhang H, Liu J, Au SW, Chan PK, Wang J, Shaw PC J Virol. 2012 Jun;86(12):6758-67. Epub 2012 Apr 11. PMID:22496219<ref>PMID:22496219</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3tj0" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Nucleoprotein|Nucleoprotein]]
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*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Influenza b virus]]
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[[Category: Large Structures]]
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[[Category: Au, S W.N.]]
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[[Category: Au SWN]]
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[[Category: Liu, J.]]
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[[Category: Liu J]]
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[[Category: Ng, A K.L.]]
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[[Category: Ng AKL]]
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[[Category: Shaw, P C.]]
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[[Category: Shaw PC]]
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[[Category: Wang, J.]]
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[[Category: Wang J]]
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[[Category: Zhang, H.]]
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[[Category: Zhang H]]
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[[Category: Homo-oligomerization]]
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[[Category: Nucleus]]
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[[Category: Rna binding protein]]
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[[Category: Rna-binding]]
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[[Category: Transcription regulation]]
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Current revision

Crystal Structure of Influenza B Virus Nucleoprotein

PDB ID 3tj0

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