4r8u

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(New page: '''Unreleased structure''' The entry 4r8u is ON HOLD Authors: Kottur, J., Nair, D.T., Weinert, T., Oligeric, V., Wang, M. Description: S-SAD structure of DINB-DNA Complex)
Current revision (08:59, 20 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 4r8u is ON HOLD
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==S-SAD structure of DINB-DNA Complex==
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<StructureSection load='4r8u' size='340' side='right'caption='[[4r8u]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4r8u]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R8U FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1FZ:5-O-[(R)-HYDROXY{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]AMINO}PHOSPHORYL]THYMIDINE'>1FZ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r8u OCA], [https://pdbe.org/4r8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r8u RCSB], [https://www.ebi.ac.uk/pdbsum/4r8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r8u ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DPO4_ECOLI DPO4_ECOLI] Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. Overexpression of polIV results in increased frameshift mutagenesis. It is required for stationary-phase adaptive mutation, which provides the bacterium with flexibility in dealing with environmental stress, enhancing long-term survival and evolutionary fitness. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.<ref>PMID:9391106</ref> <ref>PMID:11080171</ref> <ref>PMID:11463382</ref> <ref>PMID:11751576</ref> <ref>PMID:12060704</ref>
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Authors: Kottur, J., Nair, D.T., Weinert, T., Oligeric, V., Wang, M.
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==See Also==
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*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
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Description: S-SAD structure of DINB-DNA Complex
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Escherichia coli K-12]]
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[[Category: Large Structures]]
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[[Category: Synthetic construct]]
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[[Category: Kottur J]]
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[[Category: Nair DT]]
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[[Category: Oligeric V]]
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[[Category: Wang M]]
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[[Category: Weinert T]]

Current revision

S-SAD structure of DINB-DNA Complex

PDB ID 4r8u

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